Artery Research

Volume 24, Issue C, December 2018, Pages 63 - 63

GREATER AORTIC STIFFNESS IS ASSOCIATED WITH LOWER HIPPOCAMPAL CEREBROVASCULAR RESERVE BUT NOT CEREBRAL BLOOD FLOW OR AMYLOID IN MIDDLE-AGED AND OLDER ADULTS

Authors
Lyndsey E. DuBose1, Laura L. Boles Ponto2, David J. Moser3, Gary L. Pierce1, 4, 5
1Department of Health and Human Physiology, USA
2Department of Radiology, USA
3Department of Psychiatry, USA
4Center of Hypertension Research, USA
5Abboud Cardiovascular Research Center, University of Iowa, Iowa City, IA, USA
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.008How to use a DOI?
Abstract

Background: Recent studies suggests cerebrovascular dysfunction precedes amyloid deposition and cognitive impairment in Alzheimer’s disease (AD). However, if functional impairments in the hippocampus, as evidenced by reduced hippocampal cerebral blood flow (CBF) during memory stimulation and cerebrovascular reserve (CVR), are associated with aortic stiffness is unknown. Therefore, we tested the hypothesis that elevated aortic stiffness would be associated with 1) lower hippocampal CBF during memory stimulation; 2) reduced hippocampal CVR; and 3) greater hippocampal amyloid burden in middle-aged/older adults (MA/O).

Methods/Results: Twenty-four MA/O adults (range: 55–87 years; mean ± SE: 70.0 ± 2.0 years) were recruited to undergo measures of aortic stiffness (carotid-femoral pulse wave velocity, cfPWV) and global and regional CBF using quantitative [15O]water PET imaging. Regional hippocampal CBF (mL/min/100mL) was measured during memory recall of a learned word list. Hippocampal CVR was calculated as the percent (%) change in CBF in response to the pharmacological vasodilator, acetazolamide. Hippocampal amyloid burden was quantified using distribution volume ratio (DVR) from [11C]PIB PET imaging. The following correlations were adjusted for age, MAP (cfPWV only) and education (% word recall only). Elevated cfPWV was associated with reduced hippocampal CVR (r = −0.59, p = 0.005) but not hippocampal CBF (p = 0.126) or amyloid deposition (p = 0.232). Lower successful word recall trended to be associated with elevated cfPWV (r = −0.38, p = 0.097) and reduced hippocampal CVR (r = 0.38, p = 0.087) in the present cohort.

Conclusion: Elevated aortic stiffness may impair the ability of the hippocampal cerebrovasculature to augment CBF independent of basal CBF.

Funding support: NIH 5R01 AG03417, R03 AG047306-01, 1R21 AG043722, U54TR001356.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
24 - C
Pages
63 - 63
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.008How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Lyndsey E. DuBose
AU  - Laura L. Boles Ponto
AU  - David J. Moser
AU  - Gary L. Pierce
PY  - 2018
DA  - 2018/12/04
TI  - GREATER AORTIC STIFFNESS IS ASSOCIATED WITH LOWER HIPPOCAMPAL CEREBROVASCULAR RESERVE BUT NOT CEREBRAL BLOOD FLOW OR AMYLOID IN MIDDLE-AGED AND OLDER ADULTS
JO  - Artery Research
SP  - 63
EP  - 63
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.008
DO  - 10.1016/j.artres.2018.10.008
ID  - DuBose2018
ER  -