Artery Research

Volume 24, Issue C, December 2018, Pages 68 - 68

1.4 PROGNOSTIC VALUE OF PROXIMAL AORTA LONGITUDINAL STRAIN IN MARFAN SYNDROME

Authors
Andrea Guala1, Jose Rodríguez-Palomares1, Aroa Ruiz-Muñoz1, Minerva Gandara1, Violeta Sanchez2, Alberto Forteza3, David Garcia-Dorado4, Artur Evangelista4, Gisela Teixido-Tura1
1Hospital Vall d’Hebron, Department of Cardiology, VHIR, Universitat Autònoma de Barcelona, Barcelona, Spain
2University Hospital 12 de Octubre, Madrid, Spain
3Hospital Puerta del Hierro, Madrid, Spain
4Hospital Vall d’Hebron, Department of Cardiology, VHIR, Universitat Autònoma de Barcelona, Barcelona, Spain
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.021How to use a DOI?
Abstract

Background: Aortic root dilation and type A aortic dissection are the most common cardiovascular complications of Marfan syndrome (MFS). Current clinical management of MFS patients relies on a close follow-up of aortic root diameter and preventive aortic root surgery in case of severe or fast-progressing dilation. However, as the capacity of aortic diameter to predict type A aortic dissection is limited, new non-invasive biomarkers to improve risk stratification are needed. We investigated the capacity of proximal aorta circumferential and longitudinal strain and ascending aorta distensibility to predict aortic root diameter dilation and occurrence of major cardiovascular events in Marfan patients.

Methods: Eighty-seven Marfan patients without previous cardiac/aortic surgery or dissection were prospectively included in a multicenter follow-up. Proximal aorta longitudinal and circumferential strain and distensibility were computed from baseline CMR.

Results: During a follow-up of 81.6 ± 17 months, 11 patients underwent elective aortic root replacement, and 2 experienced type A aortic dissections. Mean dilation rate was 0.65 ± 0.67 mm/year and z-score growth rate 0.07 ± 0.13 1/year. In multivariable analysis, proximal aorta longitudinal strain but not circumferential strain and distensibility were independent predictors of diameter growth-rate (p = 0.001, p = 0.385 and p = 0.381, respectively), z-score growth-rate (p = 0.018, p = 0.515 and p = 0.484, respectively) and major cardiovascular events (p = 0.018, p = 0.064 and p = 0.205, respectively) corrected for demographic and clinical characteristics and baseline aortic root diameter.

Conclusions: In Marfan syndrome, proximal aorta longitudinal strain is an independent predictor of aortic root dilation and major cardiovascular events beyond aortic root diameter and established risk factors.

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Journal
Artery Research
Volume-Issue
24 - C
Pages
68 - 68
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.021How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Andrea Guala
AU  - Jose Rodríguez-Palomares
AU  - Aroa Ruiz-Muñoz
AU  - Minerva Gandara
AU  - Violeta Sanchez
AU  - Alberto Forteza
AU  - David Garcia-Dorado
AU  - Artur Evangelista
AU  - Gisela Teixido-Tura
PY  - 2018
DA  - 2018/12/04
TI  - 1.4 PROGNOSTIC VALUE OF PROXIMAL AORTA LONGITUDINAL STRAIN IN MARFAN SYNDROME
JO  - Artery Research
SP  - 68
EP  - 68
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.021
DO  - 10.1016/j.artres.2018.10.021
ID  - Guala2018
ER  -