Artery Research

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Volume 1, Issue S1, June 2006, Pages S46 - S46

P.082 DIFFERENTIAL ASSOCIATIONS OF LEFT ATRIUM VOLUME WITH BNP AND AORTIC STIFFNESS IN THE EARLY STAGES OF ESSENTIAL HYPERTENSION: IMPORTANCE OF MECHANICAL AND HUMORAL COMPONENTS

Authors
C. Katsaris*, C. Tsioufis, E. Taxiarchou, P. Stougiannos, M. Selima, E. Vezali, C. Stefanadis, I. Kallikazaros
Department of Cardiology, Hippokration Hospital, Athens, Greece
Available Online 13 June 2007.
DOI
10.1016/S1872-9312(07)70105-9How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Purpose: To investigate the possible interrelationship between Left atrial (LA) enlargement, BNP and aortic stiffness in essential hypertensive subjects.

Methods: 235 consecutive, newly diagnosed subjects (aged 52±10 years), with untreated essential hypertension [office BP = 151/97 mmHg] underwent echocardiography and 24-h ambulatory BP monitoring. LA volume was indexed for body surface area to estimate LA volume index (LAVI). Aortic stiffness was evaluated on the basis of the carotid-femoral pulse wave velocity (c-f PWV) measurement by an automatic device (Complior SP). The study population was divided into two groups: those with increased LAVI (>26ml/m2, n = 45) and those without increased LAVI (⩽26ml/m2, n = 181).

Results: Subjects with increased LAVI compared to those without increased LAVI did not differ regarding age, body mass index, 24-h systolic and diastolic BP and metabolic profile. Subjects with increased LAVI compared to those without increased LAVI had significantly increased 24-h pulse pressure (54.6±9.0 vs 51.3±7.9 mmHg, p < 0.05), left ventricular mass index (LVMI) (123±31 vs 99±23 g/m2, p< 0.0001), LA diameter (4.3±0.38 vs 3.9±0.34 cm, p < 0.0001) and BNP plasma levels (41.5±14 vs 19.7±10 pg/ml, p < 0.05), while did not differ regarding c-f PWV (8.2±1.3 vs 8.1±1.3 m/s, p = NS). Multiple regression analysis model revealed that LVMI and BNP were independent predictors of LAVI (p < 0.05).

Conclusions: Even in newly diagnosed essential hypertensive subjects LA enlargement is associated with increased plasma levels of BNP but not more impaired aortic stiffness. These findings support the notion that LA enlargement is closely related with humoral activation in this setting.

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Journal
Artery Research
Volume-Issue
1 - S1
Pages
S46 - S46
Publication Date
2007/06/13
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/S1872-9312(07)70105-9How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - C. Katsaris*
AU  - C. Tsioufis
AU  - E. Taxiarchou
AU  - P. Stougiannos
AU  - M. Selima
AU  - E. Vezali
AU  - C. Stefanadis
AU  - I. Kallikazaros
PY  - 2007
DA  - 2007/06/13
TI  - P.082 DIFFERENTIAL ASSOCIATIONS OF LEFT ATRIUM VOLUME WITH BNP AND AORTIC STIFFNESS IN THE EARLY STAGES OF ESSENTIAL HYPERTENSION: IMPORTANCE OF MECHANICAL AND HUMORAL COMPONENTS
JO  - Artery Research
SP  - S46
EP  - S46
VL  - 1
IS  - S1
SN  - 1876-4401
UR  - https://doi.org/10.1016/S1872-9312(07)70105-9
DO  - 10.1016/S1872-9312(07)70105-9
ID  - Katsaris*2007
ER  -