P.046 IMPAIRED ARTERIAL ELASTIC PROPERTIES IN HUMAN IMMUNODEFICIENCY VIRUS INFECTED NAïVE PATIENTS. THE ROLE OF SUBCLINICAL INFLAMMATION

G. Antoniou; C. Vlachopoulos; D. Tsiachris; H. Sambatakou; K. Baou; N. Alexopoulos; A. Archimandritis; C. Stefanadis

doi:10.1016/j.artres.2007.07.103

<Previous Article In Issue

Download article (PDF)

Next Article In Issue>

Volume 1, Issue 2, September 2007, Pages 63 - 63

P.046 IMPAIRED ARTERIAL ELASTIC PROPERTIES IN HUMAN IMMUNODEFICIENCY VIRUS INFECTED NAïVE PATIENTS. THE ROLE OF SUBCLINICAL INFLAMMATION

Authors

G. Antoniou¹, C. Vlachopoulos¹, D. Tsiachris¹, H. Sambatakou², K. Baou¹, N. Alexopoulos¹, A. Archimandritis², C. Stefanadis¹

¹1st Department of Cardiology, Athens Medical School, Hippokration Hospital, Athens, Greece

²2nd Department of Internal Medicine, Athens Medical School, Hippokration Hospital, Athens, Greece

Available Online 30 August 2007.

DOI: 10.1016/j.artres.2007.07.103 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Introduction: Subclinical inflammation has been associated with impaired arterial elastic properties. Human immunodeficiency virus (HIV) infection per se represents a model of chronic inflammation, possibly related to progression of atherosclerosis.

Purpose: To investigate the impact of HIV infection on arterial elastic properties in HIV naïve patients.

Methods: We studied 32 HIV infected naïve patients (aged 32 years, 28 males, 18 smokers) and 26 healthy individuals matched for age, sex and smoking status. Aortic augmentation index (AIx) and augmented pressure (AP) were assessed using assessment applanation tonometry of the radial artery. Carotid femoral pulse wave velocity (PWV) was estimated as an index of aortic stiffness by means of a computerized method (Complior SP).

Results: HIV patients compared to controls had increased levels of pulse pressure (52 vs. 44 mmHg, p=0.004), while there was no difference regarding body mass index and metabolic profile. AP and AIx were significantly decreased in HIV patients (0.3 vs. 4 mmHg, p=0.01 and 1% vs. 12%, p=0.005, respectively) even after correction for heart rate (0.6% vs. 8.3%. p=0.043). HIV patients and controls exhibited similar values of PWV (6 vs. 6.1 m/s, respectively, p=0.83).

Conclusions: HIV infected naïve patients compared with controls are characterized by decreased wave reflections and similar values of large artery stiffness. Peripheral vasodilatation is suggested to be the predominant mechanism, induced probably by the chronic subclinical inflammation in this setting.

<Previous Article In Issue

Download article (PDF)

Next Article In Issue>

Journal: Artery Research
Volume-Issue: 1 - 2
Pages: 63 - 63
Publication Date: 2007/08/30
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2007.07.103 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - G. Antoniou
AU  - C. Vlachopoulos
AU  - D. Tsiachris
AU  - H. Sambatakou
AU  - K. Baou
AU  - N. Alexopoulos
AU  - A. Archimandritis
AU  - C. Stefanadis
PY  - 2007
DA  - 2007/08/30
TI  - P.046 IMPAIRED ARTERIAL ELASTIC PROPERTIES IN HUMAN IMMUNODEFICIENCY VIRUS INFECTED NAïVE PATIENTS. THE ROLE OF SUBCLINICAL INFLAMMATION
JO  - Artery Research
SP  - 63
EP  - 63
VL  - 1
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2007.07.103
DO  - 10.1016/j.artres.2007.07.103
ID  - Antoniou2007
ER  -

download .riscopy to clipboard