P.002 HABITUAL ANTIOXIDANT VITAMIN INTAKE, AUGMENTATION INDEX AND FLOW MEDIATED DILATION IN HYPERTENSIVE PATIENTS AND NORMOTENSIVE CONTROLS
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- 10.1016/j.artres.2007.07.059How to use a DOI?
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Objective: We evaluated the association of daily dietary intake of antioxidants vitamins C and E with augmentation index and endothelial function in untreated essential hypertensive (HT) patients and normotensive (NT) subjects.
Methods: Dietary intake of major nutrients, total caloric intake and antioxidant vitamins were assessed with the Italian EPIC questionnaire in 200 untreated HT patients and 130 NT subjects. Augmentation index (AIx) was determined with radial applanation tonometry. Endothelium-dependent response was assessed as flow mediated dilation (FMD) of the brachial artery by high resolution ultrasounds and computerized analysis (automatic edge detection system) of brachial artery diameter modifications.
Results: AIx was significantly higher in HT patients (26.9 ± 9.6%) as compared to NT subjects (20.4 ± 11.3%), whereas FMD resulted significantly lower (5.0 ± 2.5 vs 6.2 ± 2.7; p<0.001). Calculated intake of vitamic C and E was similar in HT patients and in NT subjects (Vitamin C median 146.4± 68.7 mg/day and 149.1± 84.0 mg/day, Vitamin E median 8.68± 2.7 mg/day and 8.63± 2.9 mg/day, respectively). Multivariate analyses were controlled for smoking, physical activity status and total caloric intake. In both groups, levels of Vitamin C or E intake were not significant predictors for AIx. Finally, in both groups, levels of Vitamin C or E intake were not significant predictors for FMD.
Conclusions: No association exists between normal levels of regular food antioxidant intake, augmentation index and endothelial function in untreated essential hypertensive patients and normotensive subjects. This suggests that supplementation with vitamin C and E is necessary to show an effect on vascular function in this population.
Cite this article
TY - JOUR AU - Y. Plantinga AU - L. Ghiadoni AU - A. Magagna AU - S. Salvini AU - M. Ceroti AU - G. Masala AU - D. Palli AU - S. Taddei AU - A. Salvetti PY - 2007 DA - 2007/08/30 TI - P.002 HABITUAL ANTIOXIDANT VITAMIN INTAKE, AUGMENTATION INDEX AND FLOW MEDIATED DILATION IN HYPERTENSIVE PATIENTS AND NORMOTENSIVE CONTROLS JO - Artery Research SP - 53 EP - 53 VL - 1 IS - 2 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2007.07.059 DO - 10.1016/j.artres.2007.07.059 ID - Plantinga2007 ER -