Artery Research

Volume 1, Issue 2, September 2007, Pages 54 - 54

P.005 INCREASED ARTERIAL WALL STIFFNESS IN RESISTANT HYPERTENSIVE PATIENTS IN COMPARISON WITH ESSENTIAL HYPERTENSION

Authors
J. Rosa1, R. Holaj1, B. Strauch1, O. Petrak1, T. Pikus1, T. Zelinka1, D. Wichterle2, j. Widimsky1
13rd Department of Internal Medicine, General Faculty Hospital, Prague, Czech Republic
22nd Department of Internal Medicine, General Faculty Hospital, Prague, Czech Republic
Available Online 30 August 2007.
DOI
10.1016/j.artres.2007.07.062How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background/Aims: Arterial wall stiffness is considered as independent cardiovascular risk factor. Aim of this study was to compare arterial stiffness assessed by use of Pulse Wave Analysis (PWA) and carotid - femoral Pulse Wave Velocity (PWV) in resistant hypertensive patients to essential hypertensive patients and to normotensive control subjects (NCS).

Methods: 29 patients with resistant hypertension (RH), 35 patients with moderate to severe essential hypertension (EH) and 29 NCS were investigated. PWA and PWV were obtained using SphygmoCor applanation tonometer.

Results: PWV was significantly higher in RH group when compared to EH group and to NCS group while clinical blood pressure was comparable between RH and EH groups. However, 24h ABPM values were significantly higher in RH group than in EH group. There were no significant differences in age, duration of hypertension, body mass index (BMI), lipid profile, fasting glucose levels and creatinine levels between RH and EH groups. Carotid ultrasound and echocardiographical findings were comparable between RH and EH groups. PWV correlated with the presence of the diagnosis of RH, age, clinical SBP, brachial pulse pressure, mean 24h SBP, mean day SBP and mean night SBP. After multiple regression analysis, PWV remains significantly correlated only with the presence of the diagnosis of RH, age and with brachial pulse pressure.

Conclusions: Patients with RH have increased arterial wall stiffness, represented by carotid-femoral PWV, when compared to EH patients. The greatest determinants of PWV are the presence of RH, age and brachial pulse pressure.

Journal
Artery Research
Volume-Issue
1 - 2
Pages
54 - 54
Publication Date
2007/08/30
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2007.07.062How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - J. Rosa
AU  - R. Holaj
AU  - B. Strauch
AU  - O. Petrak
AU  - T. Pikus
AU  - T. Zelinka
AU  - D. Wichterle
AU  - j. Widimsky
PY  - 2007
DA  - 2007/08/30
TI  - P.005 INCREASED ARTERIAL WALL STIFFNESS IN RESISTANT HYPERTENSIVE PATIENTS IN COMPARISON WITH ESSENTIAL HYPERTENSION
JO  - Artery Research
SP  - 54
EP  - 54
VL  - 1
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2007.07.062
DO  - 10.1016/j.artres.2007.07.062
ID  - Rosa2007
ER  -