Artery Research

Volume 1, Issue 2, September 2007, Pages 50 - 50

06.03 NITRIC OXIDE AND ENDOTHELIUM-DERIVED HYPERPOLARIZING FACTOR REGULATE THE ADAPTATION OF HUMAN CONDUIT ARTERY MECHANICS TO CHANGES IN SHEAR STRESS

Authors
J. Bellien, M. Iacob, C. Thuillez, R. Joannides
Department of Pharmacology-Inserm U644 - Rouen University Hospital, Rouen, France
Available Online 30 August 2007.
DOI
10.1016/j.artres.2007.07.048How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

The role of NO and endothelium-derived hyperpolarizing factor (EDHF), synthesized by cytochrome epoxygenases and acting through calcium-activated potassium (KCa) channels, in the flow-mediated regulation of human conduit artery mechanics has never been investigated.

In 11 healthy volunteers, whole blood viscosity, arterial pressure, radial artery diameter, wall thickness and flow (echotracking) were measured during hand skin heating in the presence of saline and the NO-synthase inhibitor, L-NMMA, infused alone and combined with the inhibitors of KCa channels, tetraethylammonium, and cytochrome epoxygenases, fluconazole. Wall shear stress, the flow-dependent stimulus, was calculated (Poiseuillean model). Arterial compliance, elastic wall modulus were calculated and fitted as functions of midwall stress (wall loading conditions) to suppress the confounding influence of changes in geometry.

Heating induced in all cases an increase in radial artery flow, diameter, shear stress and midwall stress and a decrease in wall thickness without change in arterial pressure. The increase in diameter with shear stress was reduced by L-NMMA and, in a more extent, by both combinations. Heating induced an upward shift of the compliance-midwall stress curve and a downward shift of the modulus-midwall stress curve under saline demonstrating an associated decrease in smooth muscle tone and wall stiffness with the shear stress increase. The shifts of these curves were decreased by L-NMMA and abolished by both combinations.

These results demonstrate that NO and EDHF regulate the adaptation of conduit artery mechanics to shear stress variations in humans suggesting the major role of the endothelium in maintaining arterial conductance and adjusted cardiac load.

Journal
Artery Research
Volume-Issue
1 - 2
Pages
50 - 50
Publication Date
2007/08/30
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2007.07.048How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - J. Bellien
AU  - M. Iacob
AU  - C. Thuillez
AU  - R. Joannides
PY  - 2007
DA  - 2007/08/30
TI  - 06.03 NITRIC OXIDE AND ENDOTHELIUM-DERIVED HYPERPOLARIZING FACTOR REGULATE THE ADAPTATION OF HUMAN CONDUIT ARTERY MECHANICS TO CHANGES IN SHEAR STRESS
JO  - Artery Research
SP  - 50
EP  - 50
VL  - 1
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2007.07.048
DO  - 10.1016/j.artres.2007.07.048
ID  - Bellien2007
ER  -