P4.48 SUPERIOR PERIPHERAL AND CENTRAL BLOOD PRESSURE (BP) CONTROL AFTER SWITCHING HYPERTENSIVE TYPE 2 DIABETIC PATIENTS WITH UNCONTROLLED HYPERTENSION UNDER RAMIPRIL/HCT TO PERINDOPRIL/INDAPAMIDE
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The aim of the present study was to compare the change from baseline BP (office, 24-h ABPM, central BP) in uncontrolled, hypertensive typ 2 Dm patients under ramipril/HCT after switching therapy to a dose-equivalent fixed combination of perindopril/indapamide Investigator initiated, non-randomized, one arm study. Typ 2 Dm, males and females >18, with previously uncontrolled hypertension as defined by a sitting office BP ≥130/80 mmHg (office BP). Triplicate office BP was measured with a validated, fully automatic, oscillometric upper arm device (ESH guidelines; Microlife watch BP office). 24-h-ABPM (Central and peripheral BP) was measured with a validated device at baseline and after 8 weeks therapy (Mobilograph, IEM, Germany) Central BP in the clinic was measured at baseline and after 4 and 8 weeks therapy according to the recommendations of the ESH working group on Large Arteries (Sphygmocor, Atcor)
Results: Up to now 18 patients with a mean age of 61±10 years and a BMI von 30±6 were included. Mean daily dosage of Ramipril/HCT was 5.3/22.2 mg, the respective dosage after changing to Perindopril/Indamide was 5.97/1.49.
| PSBP | PDBP | cSBP | cDBP | 24h-SBP | 24h-DBP | 24h-cSBP | 24h-cDBP | |
|---|---|---|---|---|---|---|---|---|
| Baseline | 144±12 | 84±8 | 130±11 | 85±8 | 131±10 | 78±9 | 119±11 | 80±10 |
| Week 8 | 138±15 | 83±7 | 125±11 | 84±8 | 127±8 | 74±9 | 113±7 | 77±9 |
| p | 0,0285 | 0,231 | 0,013 | 0,366 | 0,0067 | 0,0152 | 0,0025 | 0,077 |
P = peripheral, S = systolic, D = diastolic, BP = blood pressure, c = central, 24-h = ambulatory 24-h mean
Switching hypertensive Typ 2 diabetic patients with uncontrolled hypertension under Ramipril/HCT to Perindopril/Indapamide resulted mainly in superior systolic blood pressure control. This effect was persistent for central BP as well as for 24-h-ABPM.
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TY - JOUR AU - T. Mengden AU - W. Sehnert PY - 2012 DA - 2012/11/17 TI - P4.48 SUPERIOR PERIPHERAL AND CENTRAL BLOOD PRESSURE (BP) CONTROL AFTER SWITCHING HYPERTENSIVE TYPE 2 DIABETIC PATIENTS WITH UNCONTROLLED HYPERTENSION UNDER RAMIPRIL/HCT TO PERINDOPRIL/INDAPAMIDE JO - Artery Research SP - 196 EP - 196 VL - 6 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2012.09.195 DO - 10.1016/j.artres.2012.09.195 ID - Mengden2012 ER -