P4.57 STIFFNESS OF THE LARGE ARTERIES IN INDIVIDUALS WITH AND WITHOUT DOWN SYNDROME
- DOI
- 10.1016/j.artres.2012.09.204How to use a DOI?
- Keywords
- aging; Down syndrome; pulse wave velocity; arterial stiffness
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Background: Down syndrome (DS) is known to cause premature aging in several organ systems1. In this controlled study, the possibility of changes in the large arteries due to aging was evaluated in patients with DS1.
Methods: Eighty-two subjects of both genders were selected. The DS group had 41 active subjects. The control group was consisted of 41 healthy matched for age and gender. Carotid–femoral pulse wave velocity was obtained as an index of aortic stiffness using an automatic noninvasive method2.
Results: The general characteristics of the groups and the main results are shown in Table 1 and Figure.
| DOWN SYNDROME (n=41) | CONTROL (n=41) | P value | |
|---|---|---|---|
| Age (years) Variance | 21 ± 1 (13–42) | 21 ± 1 (13–42) | - |
| Weight (kg) | 55 ± 2 | 61 ± 2 | < 0.05 |
| Height (m) | 1.47 ± 0.01 | 1.64 ± 0.01 | < 0.001 |
| BMI (kg.m−2) | 25 ± 1 | 22 ± 1 | < 0.01 |
| WHR | 0.88 ± 0.01 | 0.80 ± 0.01 | < 0.001 |
| SBP (mmHg) | 106 ± 2 | 117 ± 2 | < 0.001 |
| DBP (mmHg) | 66 ± 2 | 77 ± 2 | < 0.001 |
| MAP (mmHg) | 80 ± 1 | 90 ± 1 | < 0.001 |
| HR(bpm) | 74 ± 2 | 76 ± 2 | NS |
| PWV (m/s) | 7.51 ± 0.14 | 7.84 ± 0.12 | < 0.05 |
Data are expressed as mean ± standard error (SEM).
Abbreviations: DS = Down syndrome; BMI = body mass index; WHR = waist-hip ratio; SBP = systolic blood pressure; DBP = diastolic blood pressure; MAP = mean arterial pressure; HR = heart rate; PWV= pulse wave velocity; NS = not significant.
Anthropometric and hemodynamic characteristics in the experimental groups.
Multivariate linear regression model with Pearson’s correlation coefficient between age, systolic blood pressure, and carotid–femoral pulse wave velocity in controls and subjects with Down syndrome.
Conclusion: Despite evidence in the literature that patients with DS undergo early aging1, this process does not seem to affect the large arterial trunks3. Considering that DS presents with chronic hypotension, it is reasonable to propose that the prolonged reduction of arterial distending pressure may contribute to functional preservation of the arteries in patients with Down syndrome
References
Cite this article
TY - JOUR AU - A. Rodrigues AU - L. Coelho AU - W. Gonçalves AU - M. Vasconcellos AU - R. Cunha AU - S. Gouvea AU - G. Abreu PY - 2012 DA - 2012/11/17 TI - P4.57 STIFFNESS OF THE LARGE ARTERIES IN INDIVIDUALS WITH AND WITHOUT DOWN SYNDROME JO - Artery Research SP - 199 EP - 199 VL - 6 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2012.09.204 DO - 10.1016/j.artres.2012.09.204 ID - Rodrigues2012 ER -