Artery Research

Volume 4, Issue 4, December 2010, Pages 184 - 184

P13.03 THE PATIENTS WITH LACUNAR ISCHEMIC STROKE (LIS) HAVE ENDOTHELIAL DYSFUNCTION (ED) AND INCREASED ARTERIAL STIFFNESS

Authors
O.B. Kerbikov1, E.N. Borskaya2
1Russian State Medical University, Moscow, Russian Federation
2Federal State Clinical Hospital #86, Moscow, Russian Federation
Available Online 2 December 2010.
DOI
10.1016/j.artres.2010.10.135How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

ED is thought to be implicated in the pathogenesis of cerebral small vessel disease in patients with LIS while the role of arterial stiffness is less known.

Objective: The aim of this study was to assess the endothelial function (EF) and arterial stiffness in patients with LIS.

Methods: In this study, 35 patients with LIS, as defined by clinical characteristics and MRI findings were compared with 18 healthy age and gender-matched patients with similar risk factors.

EF was assessed using the brachial flow-mediated vasodilatation (FMD); in LIS group on the first day after stroke onset. Carotid stiffness index ß was calculated as follows: ln(systolic/diastolic blood pressure)/([Dmax-Dmin]/Dmin), where Dmax and Dmin are maximum and minimum common carotid lumen diameters measured by carotid ultrasound. Carotid intima-media thickness (IMT) was also measured. FMD was categorized according to ROC analysis and ED was defined as FMD ≤ 6.0%.

Results: Twenty-two (63%) LIS patients had ED on the 1st day and only three patients (17%) in the control group (p<0.05). FMD was lower in LIS group (6.1±2.5% versus 9.8±2.2% in the control group, p=0.02), while carotid stiffness was higher (10.5±2.2 versus 7.5±2.6, p=0.04). There was not significant difference in IMT between two groups (0.91±0.17 versus 0.87±0.21, p=0.4). Moderate correlation was observed between stiffness and IMT (r=0.33, p=0.01). No correlations were found between FMD and IMT, FMD and arterial stiffness.

Conclusion: The majority of patients with LIS have the impairment of the structural-and-functional properties of the arterial wall that manifest in the ED and increased stiffness.

Journal
Artery Research
Volume-Issue
4 - 4
Pages
184 - 184
Publication Date
2010/12/02
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2010.10.135How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - O.B. Kerbikov
AU  - E.N. Borskaya
PY  - 2010
DA  - 2010/12/02
TI  - P13.03 THE PATIENTS WITH LACUNAR ISCHEMIC STROKE (LIS) HAVE ENDOTHELIAL DYSFUNCTION (ED) AND INCREASED ARTERIAL STIFFNESS
JO  - Artery Research
SP  - 184
EP  - 184
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.135
DO  - 10.1016/j.artres.2010.10.135
ID  - Kerbikov2010
ER  -