Artery Research

<Previous Article In Issue
Download article (PDF)
Next Article In Issue>
Volume 4, Issue 4, December 2010, Pages 180 - 180

P11.07 DIFFERENCE BETWEEN SYSTOLIC AND DIASTOLIC CAROTID ARTERY STIFFNESS IS INDEPENDENTLY ASSOCIATED WITH LEFT VENTRICULAR MASS INDEX IN HEALTHY MIDDLE-AGED SUBJECTS

Authors
K.D. Reesink1, E. Hermeling1, S.J. Vermeersch2, E.R. Rietzschel2, M.L. De Buyzere2, T. Gillebert2, R.J. van de Laar1, I. Ferreira1, A.P.G. Hoeks1, L.M. van Bortel2, R.S. Reneman1, P. Segers2
1Maastricht University, Maastricht, Netherlands
2Ghent University, Ghent, Belgium
Available Online 2 December 2010.
DOI
10.1016/j.artres.2010.10.120How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: Arterial stiffening potentially plays a role in cardiac hypertrophy. We recently demonstrated in patients that arterial stiffness can be substantially pressure dependent and, here, introduce a non-invasive measure to quantify the pressure dependence in the carotid artery, defined as the difference between systolic and diastolic pulse wave velocity (PWVdiff). Both PWVdiff and peripheral wave reflections (quantified by augmentation index, AIx) are biomechanically related to (late) systolic pressure increase. Therefore, we investigated the associations of PWVdiff and AIx with left ventricular mass index (LVMI).

Methods and Results: In 1522 subjects of the Asklepios cohort (age 35‑55 yrs, healthy) PWVdiff was calculated from segmental distensibility coefficients, as obtained by carotid artery ultrasound and tonometry (Figure). PWVdiff ranged from 0.7 to 4.4 m/s. Linear regression analysis showed a significant association of PWVdiff with LVMI (β of 1.26 g/m2.7 per m/s, 95% CI: 0.91–1.62), which remained significant after adjusting for covariates (p=0.03). AIx showed no consistent association with LVMI.

Conclusions: Carotid PWVdiff is independently associated with left ventricular mass index in presumed healthy middle-aged subjects. Non-invasive carotid artery ultrasound and tonometry enable assessment of the contribution of pressure dependent stiffness to LV pressure load, independently of wave reflections.

<Previous Article In Issue
Download article (PDF)
Next Article In Issue>
Journal
Artery Research
Volume-Issue
4 - 4
Pages
180 - 180
Publication Date
2010/12/02
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2010.10.120How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - K.D. Reesink
AU  - E. Hermeling
AU  - S.J. Vermeersch
AU  - E.R. Rietzschel
AU  - M.L. De Buyzere
AU  - T. Gillebert
AU  - R.J. van de Laar
AU  - I. Ferreira
AU  - A.P.G. Hoeks
AU  - L.M. van Bortel
AU  - R.S. Reneman
AU  - P. Segers
PY  - 2010
DA  - 2010/12/02
TI  - P11.07 DIFFERENCE BETWEEN SYSTOLIC AND DIASTOLIC CAROTID ARTERY STIFFNESS IS INDEPENDENTLY ASSOCIATED WITH LEFT VENTRICULAR MASS INDEX IN HEALTHY MIDDLE-AGED SUBJECTS
JO  - Artery Research
SP  - 180
EP  - 180
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.120
DO  - 10.1016/j.artres.2010.10.120
ID  - Reesink2010
ER  -