P11.09 SYSTEMIC ARTERIAL PROPERTIES IN WOMEN 3 YEARS AFTER A PRE-ECLAMPTIC PREGNANCY
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- 10.1016/j.artres.2010.10.122How to use a DOI?
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Purpose: Pre-eclampsia is defined by hypertension and proteinuria, occurs in 3-10% of all pregnancies. The pathohysiological adaptation of systemic arterial properties has not been described. We performed a comprehensive study of systemic arterial properties in women with previous pre-eclamptic pregnancy (PPEP) as compared to women with previous normal pregnancy (PNP).
Methods: 35 women (37±4 years) with PPEP (3.5±1.0 years) and 65 (33±1 years) with PNP (6 months postpartum), were studied. Aortic root pressure and flow were obtained by calibrated right subclavian artery pulse trace, and aortic annular Doppler blood flow recordings. Systemic arterial properties were described by total arterial compliance(C), arterial elastance (Ea), characteristic impedance (Z0), and peripheral arterial resistance (R). Wave reflection was assessed as the ratio of the magnitude of the backward (Pb) to forward (Pf) pressure wave. Parameters were estimated by Fourier analysis of central aortic pressure and flow data and methods based on the 2-element windkessel model.
Results: (Table) Women with PPEP had significantly higher blood pressure than PNP. R was not significantly different between the groups, but Z0 and Ea were significantly higher, and C trended lower in the PPEP group. There was significantly higher amplitude in both forward and backward.
Conclusions: The higher blood pressures in women with PEP is not explained by higher peripheral arterial resistance, but is likely related to a stiffer proximal aorta, and lower arterial compliance. This may relate to the higher risk for later cardiovascular events observed in women with PEP.
| PPEP | PNP | P | |
|---|---|---|---|
| Mean arterial pressure (mmHg) | 102±17 | 86±8 | <0.001 |
| Systolic pressure (mmHg) | 129±21 | 110±9 | 0.002 |
| Heart rate (min−1) | 70±7 | 66±7 | 0.011 |
| Cardiac output (l min−1) | 5.5±1.2 | 4.9±0.9 | 0.020 |
| R (mmHg ml−1 s−1) | 1.16± 0.31 | 1.10±0.29 | 0.295 |
| Z0 (10־3mmHg ml−1 s−1) | 72±30 | 55±22 | 0.004 |
| C WK (ml mmHg−1) | 1.28±0.42 | 1.40±0.45 | 0.239 |
| C PPM (ml mmHg−1) | 1.03±0.33 | 1.14±0.30 | 0.104 |
| Ea (mmHg ml−1) | 1.45±0.39 | 1.27±0.28 | 0.004 |
| Amplitude Forward Wave (Pf; mmHg) | 36±9 | 30±6 | 0.001 |
| Amplitude Backward Wave (Pb; mmHg) | 22±8 | 19±4 | 0.017 |
| Reflection magnitude (Pb/Pf) | 0.60±0.13 | 0.64±0.13 | 0.145 |
Mean±SD. p<0.05 (unpaired t-test). WK = C obtained using windkessel model fit; PPM= pulse pressure method.
Cite this article
TY - JOUR AU - M.E. Estensen AU - E.W. Remme AU - A. Swillens AU - T. Henriksen AU - O.A. Smiseth AU - L. Gullestad AU - P. Segers AU - S. Aakhus PY - 2010 DA - 2010/12/02 TI - P11.09 SYSTEMIC ARTERIAL PROPERTIES IN WOMEN 3 YEARS AFTER A PRE-ECLAMPTIC PREGNANCY JO - Artery Research SP - 180 EP - 181 VL - 4 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2010.10.122 DO - 10.1016/j.artres.2010.10.122 ID - Estensen2010 ER -