P6.04 EFFECT OF CAROTID BARORECEPTOR ACTIVATION ON AORTIC STIFFNESS

P. Segers; J. Kips; S.J. Vermeersch; D. Georgakopoulos

doi:10.1016/j.artres.2010.10.074

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Volume 4, Issue 4, December 2010, Pages 166 - 166

P6.04 EFFECT OF CAROTID BARORECEPTOR ACTIVATION ON AORTIC STIFFNESS

Authors

P. Segers¹, J. Kips¹, S.J. Vermeersch¹, D. Georgakopoulos²

¹Ghent University, Gent, Belgium

²CVRx Inc., Minneapolis, MN, United States of America

Available Online 2 December 2010.

DOI: 10.1016/j.artres.2010.10.074 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Background: Previous research in acute animal models demonstrated strong effects of electrical carotid baroreceptor activation (CBA) on central hemodynamics. Data indicated arterial tone relaxation, which we could indirectly demonstrate at the level of the renal artery with a reduced impedance with CBA. The aim of this study was to assess effects of CBA on the elastic properties of the aorta.

Methods: The following data were invasively recorded in 7 anaesthetized dogs at baseline (BL) and during CBA intended to produce a moderate reduction in mean arterial pressure: (i) upper thoracic pressure (Pao; hi-fi pressure sensor) and flow (transonic flow probe) providing reflection magnitude Pb/Pf; (ii) Pao and diameter (ultrasonic crystals) providing local aortic distensibility (DC); PWV from simultaneous pressure recordings distance 21 cm (PWV-thoracic) and 51 cm (PWV-aorta) apart.

Results: see Table (mean (stdev)); P: paired t-test.

	CTRL	CBA	P
MAP(mmHg)	85.5 (9.0)	61.4 (6.7)	0.0007
Pb/Pf	0.44 (0.02)	0.36 (0.06)	0.005
DC (%/10 mmHg)	4.29 (1.08)	4.12 (0.91)	0.765
PWV-thoracic (m/s)	4.85 (0.40)	4.42 (0.52)	0.007
PWV-aorta (m/s)	6.78 (0.47)	5.75 (0.39)	0.0001

Discussion and conclusion: CBA lowered Pb/Pf and PWV, the latter effect mainly confined to the abdominal (muscular) aorta, given (i) the more substantial decrease in aortic (−1 m/s) versus thoracic (−0.4 m/s) PWV, and (ii) the absence of any change in DC measured directly at the upper thoracic aorta despite the reduction. Based on these and previous findings, we conclude that CBA modulates arterial tone in muscular arteries including the muscular parts of the aorta.

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Journal: Artery Research
Volume-Issue: 4 - 4
Pages: 166 - 166
Publication Date: 2010/12/02
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2010.10.074 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - P. Segers
AU  - J. Kips
AU  - S.J. Vermeersch
AU  - D. Georgakopoulos
PY  - 2010
DA  - 2010/12/02
TI  - P6.04 EFFECT OF CAROTID BARORECEPTOR ACTIVATION ON AORTIC STIFFNESS
JO  - Artery Research
SP  - 166
EP  - 166
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.074
DO  - 10.1016/j.artres.2010.10.074
ID  - Segers2010
ER  -

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