The cardio-ankle vascular index (CAVI) has been recently reported as a new index of aortic stiffness, which is less influenced by blood pressure than the previous standard, brachial-ankle pulse wave velocity (baPWV). Recent studies have shown that CAVI is a more accurate predictor of the current severity of atherosclerotic disease than baPWV. The AIM of this study was to establish which of the two parameters (baPWV or CAVI) has a higher predictive value for major adverse cardiovascular events (MACE) in men with Coronary Artery Disease (CAD). METHODS AND RESULTS: baPWV and CAVI measurement were performed on 224 men with CAD (mean age 56.2±8.9). The examination measured body mass index, blood pressure, blood glucose and total cholesterol. During the 3.5-year follow-up period 38 patients experienced MACE (acute myocardial infarction, coronary intervention, or cardiac death). A receiver operating characteristic curve demonstrated that the best cut-off point for baPWV to predict MACE was 14.0 m/s (AUC=0.69, p<0.001) whereas for CAVI the value is 8.1(AUC=0.61, p=0,027). Univariate Cox analyses demonstrated that baPWV had a significant risk ratio (RR) for MACE (RR=4.59, CI95%=2.43–8.67, p<0.001), while CAVI was not significantly associated with MACE (RR=1.93, CI 95% =0.99–3.39, p=0.055). Multivariate Cox analyses demonstrated that independent of age, mean BP and other risk factors, baPWV was a predictor of MACE. The sensitivity of baPWV was 71%, and its specificity was 67%. CONCLUSIONS: baPWV is the only significant predictor of MACE for men with CAD, while CAVI does not independently relate to meaningful 3.5 year prognosis in this cohort.