Artery Research

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Volume 4, Issue 4, December 2010, Pages 151 - 151

8.3 REDUCED SYSTEMIC ARTERIAL COMPLIANCE IN STABLE HEART TRANSPLANT PATIENTS

Authors
L.A. Rustad1, 2, *, K. Nytrøen1, B.H. Amundsen2, P. Segers3, S. Aakhus1
1Oslo University hospital, Rikshospitalet, Oslo, Norway
2NTNU, Dept. of Circulation and Medical Imagine, Trondheim, Norway
3University of Ghent, Inst. of Biomedical Engineering, Ghent, Belgium
*Corresponding author.
Corresponding Author
L.A. Rustad
Available Online 2 December 2010.
DOI
10.1016/j.artres.2010.10.186How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Purpose: Despite high prevalence of cardiovascular diseases in heart transplanted patients (HTx), the global systemic arterial properties are not well described. Thus, the aim of this study was to evaluate arterial properties in HTx.

Methods: 26 stable heart transplanted patients (age 50±17 years (mean±SD)) with no signs of rejection or cardiac failure were investigated 4.5±1.8 years after HTx and compared with healthy age-matched subjects with either normal blood pressure or similar brachial mean arterial blood pressure (MAP). Aortic root pressure and flow data were obtained by semi-simultaneous recordings of aortic root Doppler flow velocities, brachial arterial blood pressure and calibrated carotid arterial pulse trace. Systemic arterial properties were described by total arterial compliance(C), arterial elastance (Ea), characteristic impedance (Z0), and peripheral vascular resistance (TVR). Parameters were estimated by Fourier analysis of central aortic pressure and flow data and methods based on the 2-element windkessel model (pulse pressure method).

Results(Table): HTx patients had significantly higher Ea and lower C compared with the normotensive subjects. However, C trended lower (p=0.07) in the MAP-matching group compared with the normotensive subjects.

Conclusion: Systemic arterial properties in HTx differ significantly from normotensive subjects; however only small variations were seen compared to the MAP-control group. Thus, the low compliance is likely due to a pressure-dependent effect.

TxCor MAP-control Normotensive P-ANOVA
Subjets (men/women) 26 (19/7) 22 (17/5) 24 (16/8)
MAP (mmHg) 102 ± 12 103 ± 7 † 89 ± 6 ** < 0.001
Heart rate (beats/s) 79 ± 13 62 ± 9 ** 60 ± 9 ** < 0.001
Cardiac output (l/min) 5.0 ± 1.1 5.1 ± 1.3 4.8 ± 1.0 0.57
TVR (mmHg/(ml/s)) 1.28 ± 0.4 1.26 ± 0.3 1.17 ± 0.3 0.41
Z0 (10־3mmHg/(ml/s)) 98 ± 29 104 ± 25 111 ± 41 0.36
C (ml/mmHg) 0.88 ± 0.3 0.95 ± 0.2 1.12 ± 0.2** 0.005
Ea (mmHg/ml) 1.74 ± 0.5 1.43 ± 0.3 * 1.27 ± 0.4** 0.001

Mean±SD,

*

p<0.05 and

**

p<0.005 compared with TxCor.

†

p<0.005 compared with normotensive subjects.

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Journal
Artery Research
Volume-Issue
4 - 4
Pages
151 - 151
Publication Date
2010/12/02
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2010.10.186How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - L.A. Rustad
AU  - K. Nytrøen
AU  - B.H. Amundsen
AU  - P. Segers
AU  - S. Aakhus
PY  - 2010
DA  - 2010/12/02
TI  - 8.3 REDUCED SYSTEMIC ARTERIAL COMPLIANCE IN STABLE HEART TRANSPLANT PATIENTS
JO  - Artery Research
SP  - 151
EP  - 151
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.186
DO  - 10.1016/j.artres.2010.10.186
ID  - Rustad2010
ER  -