P1.09 VALIDATION OF A NEW NON-INVASIVE TONOMETER FOR DETERMINING AORTIC PULSE WAVE VELOCITY IN RATS

E. Tartagni; G. Simon; C. Labat; N. Sloboda; L. Joly; C. Borghi; A. Benetos; P. Lacolley; P. Salvi

doi:10.1016/j.artres.2010.10.014

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Volume 4, Issue 4, December 2010, Pages 155 - 155

P1.09 VALIDATION OF A NEW NON-INVASIVE TONOMETER FOR DETERMINING AORTIC PULSE WAVE VELOCITY IN RATS

Authors

E. Tartagni¹^{, 2}, G. Simon¹, C. Labat¹, N. Sloboda¹, L. Joly¹, C. Borghi², A. Benetos¹, P. Lacolley¹, P. Salvi¹^{, 2}

¹INSERM U961 and Dept of Geriatrics - University of Nancy, Nancy, France

²Dept of Internal Medicine University of Bologna, Bologna, Italy

Available Online 2 December 2010.

DOI: 10.1016/j.artres.2010.10.014 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Carotid-femoral pulse wave velocity (PWV) is an established method for characterizing aortic stiffness. At present, to determine PWV in rats, the gold standard method is a surgical invasive measurement; inevitably this leads to the animal’s death. The objective of this study is to validate a new device for determining non-invasive PWV measurements which allows longitudinal studies in rats.

The PulsePenLab (DiaTecne), the device validated in this study, was derived from the PulsePen model, a validated high-fidelity tonometer, currently used to assess PWV non-invasively in humans. Two PulsePen tonometers recorded simultaneously carotid and femoral blood pressure pulse wave. The probes were positioned and fixed on the arteries by means of mechanical arms. The acquisition sample rate was 1KHz. Carotid-femoral PWV was determined by two operators, and measurements were repeated after a week. Immediately after this second test, a surgical invasive measurement of PWV was performed. The real sternum-carotid and sternum-femoral distances were compared with the external distances previously acquired by the two operators.

Now we present the preliminary data concerning the early 8 rats (Zucker fa/fa and Fa/Fa) included in this study. PWV determined by the PulsePenLab was compared with the traditional invasive measurement: the difference between the values of two measurements was 0.13±0.66 m/s, R=0.71. All values of difference were <1.0 m/s. Reproducibility of measurements was determined by inter-observer coefficient of repeatability (0.92 m/s) and coefficient of variation (9.79%).

These preliminary data suggest that PulsePenLab is an efficient device for determining a non-invasive measurement of PWV in rats.

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Journal: Artery Research
Volume-Issue: 4 - 4
Pages: 155 - 155
Publication Date: 2010/12/02
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2010.10.014 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - E. Tartagni
AU  - G. Simon
AU  - C. Labat
AU  - N. Sloboda
AU  - L. Joly
AU  - C. Borghi
AU  - A. Benetos
AU  - P. Lacolley
AU  - P. Salvi
PY  - 2010
DA  - 2010/12/02
TI  - P1.09 VALIDATION OF A NEW NON-INVASIVE TONOMETER FOR DETERMINING AORTIC PULSE WAVE VELOCITY IN RATS
JO  - Artery Research
SP  - 155
EP  - 155
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.014
DO  - 10.1016/j.artres.2010.10.014
ID  - Tartagni2010
ER  -

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