Background/Objectives: Within the last decade the quantification of pulse wave reflections focused on aortic systolic pressure and its augmentation based on analysis of pressure waves alone. A different approach is wave separation analysis (WSA), which quantifies the total amount of arterial wave reflection considering both aortic pulse and flow waves. The aim of this work is the development of an accurate ventricular blood flow model based on central blood pressure waveform for proper WSA and its validation against Doppler ultrasound.

Methods: The introduced ARCSolver method, which grounds on higher order mathematical flow models, describes and implements the outflow of the left ventricle during systole based on a non invasive estimated central pressure waveform. To evaluate the performance of the proposed approach, comparisons against reference Doppler measurements and triangular flow models are made for 131 patients.

Results: Against Doppler the mean difference and standard deviation of the amplitudes of the decomposed forward and backward pressure waves are −0.4 (1.68) mmHg (Fig A) and −1.41 (1.44) mmHg (Fig B). The corresponding mean RMSE for the separated pressure curves is 0.93 (0.51). The results indicate that the ARCSolver method provides accurate estimates of investigated parameters.

Conclusion: The comparison with Doppler ultrasound flow waves as well as recently proposed simple triangular flow waves showed that our approach reduces variability and provides accurate results.