Artery Research

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Volume 8, Issue 4, December 2014, Pages 178 - 188

Carotid haemodynamics during sympathetic nervous system stimulation via handgrip and cold pressor testing in young healthy subjects: A feasibility study

Authors
F.J. Londonoa, *, T.S. Klopmeijerb, D. Georgakopoulosc, E.G. Lovettc, L. Van Borteld, P. Segersa
aIBitech-bioMMeda (Ghent University), iMinds Medical IT, Ghent, Belgium
bEindhoven University of Technology, Eindhoven, Netherlands
cCVRx Inc., Minneapolis, MN, United States
dHeymans Institute of Pharmacology, Ghent, Belgium
*Corresponding author. E-mail addresses: FranciscoJavier.LondonoHoyos@Ugent.be (F.J. Londono), t.s.klopmeijer@student.tue.nl (T.S. Klopmeijer), dgeorgakopoulos@cvrx.com (D. Georgakopoulos), elovett@cvrx.com (E.G. Lovett), Luc.VanBortel@UGent.be (L. Van Bortel), Patrick.Segers@UGent.be (P. Segers).
Corresponding Author
F.J. Londono
Received 14 May 2014, Accepted 27 August 2014, Available Online 20 September 2014.
DOI
10.1016/j.artres.2014.08.001How to use a DOI?
Keywords
Biosignals; Medical imaging; Arterial stiffness; Baroreflex; Cardiovascular control
Abstract

Introduction: Assessing arterial and haemodynamic properties in response to a physiological perturbation might provide additional information on an individual’s “vascular health”. The aim of this study was to assess the feasibility of measuring changes in carotid stiffness and haemodynamics in response to sympathetic nervous system stressors, such as the Hand Grip Test (HGT) and the Cold Pressor Test (CPT).

Methods: A non-invasive protocol, consisting of two HGT’s at 30% and 40% of maximal voluntary contraction and a CPT, was performed in 12 young healthy volunteers (6 males/6 females). Measurements included continuous finger blood pressure recordings (NexFin; non-dominant hand) and ultrasound measurement of common carotid diameter distension and flow velocity at discrete moments in time during the protocol (GE Vivid 7 system). Carotid distension (ΔD/D), local wave speed using the waterhammer equation (PWVWH) and reflection magnitude (RM; ratio of backward to forward diameter wave) were derived from the data.

Results: Consistent with the overall increase in blood pressure, carotid diameter increased while ΔD/D decreased. PWVWH and RM showed high variability during both HGT’s and CPT.

Conclusion: It is feasible to monitor the carotid haemodynamic response to selected sympathetic nervous system stimulus. Moreover, the analysis showed supporting evidence of specific physiological response to regulate adequately each stress stimulus.

Copyright
© 2014 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
8 - 4
Pages
178 - 188
Publication Date
2014/09/20
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2014.08.001How to use a DOI?
Copyright
© 2014 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - F.J. Londono
AU  - T.S. Klopmeijer
AU  - D. Georgakopoulos
AU  - E.G. Lovett
AU  - L. Van Bortel
AU  - P. Segers
PY  - 2014
DA  - 2014/09/20
TI  - Carotid haemodynamics during sympathetic nervous system stimulation via handgrip and cold pressor testing in young healthy subjects: A feasibility study
JO  - Artery Research
SP  - 178
EP  - 188
VL  - 8
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2014.08.001
DO  - 10.1016/j.artres.2014.08.001
ID  - Londono2014
ER  -