Artery Research

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Volume 8, Issue 4, December 2014, Pages 175 - 176

PO-27 HIGHER CENTRAL AUGMENTATION PRESSURE/INDEX IS ASSOCIATED WITH TENSION-TYPE HEADACHE BUT NOT MIGRAINE IN MIDDLE-AGED/OLDER OBESE HUMANS

Authors
Grazi Kalila, b, Ana Recoberc, William G. Haynesb, M. Bridget Zimmermane, Gary L. Piercea, d
aDepartment of Health and Human Physiology, University of Iowa, Iowa City, IA, USA
bDepartment of Internal Medicine, Division of Endocrinology and Metabolism, University of Iowa, Iowa City, IA, USA
cDepartment of Neurology, University of Iowa, Iowa City, IA, USA
dFraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
eDepartment of Biostatistics and Institute for Clinical and Translational Science, University of Iowa, Iowa City, IA, USA
Available Online 4 November 2014.
DOI
10.1016/j.artres.2014.09.033How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Objectives: Obesity is associated with a five-fold increased risk of developing chronic daily headache, especially chronic migraine. Migraine attacks are more frequent and more severe among obese migraineurs and they improve with weight loss; however, the underlying mechanisms are unknown. Given that elevated aortic stiffness and central pulse pressure are associated with cerebral microvascular dysfunction/damage, we hypothesized that obese middle-aged/older adults with history of migraine would demonstrate higher aortic stiffness, central blood pressure (BP) and augmentation index (AI) /pressure (AP) compared with those without a history of migraine.

Methods: Middle-aged/older obese adults who were stratified (via detailed survey and physical exam by a neurologist) by presence of migraine (n=39; age 54 ± 8 yrs, BMI 38 ± 6 kg/m2, 67% female), tension-type headache (n=25; age 57 ± 6 yrs, BMI 37 ± 4 kg/m2, 72% female) or no headache of any type (n=29; age 54 ± 7 yrs, BMI 37± 5, 37± 5 kg/m2, 48% female) had aortic stiffness (carotid-femoral pulse wave velocity, CFPWV), brachial and central BP, and central AI and AP assessed by applanation tonometry (SphygmoCor).

Results: Obese adults with tension-type headache, but not migraine (P=0.29), demonstrated higher AI (25.4 ± 9.6 vs. 17.8 ± 6.9%, P=0.02) and AP (11.7 ± 9.6 vs. 6.8 ± 6.9 mmHg, P=0.01) compared with no headache controls, but no difference in CFPWV between the 3 groups (P=0.47). After adjusting for age, mean BP, female sex, weight, height, and antihypertensive medication, higher AP (β=2.95, p=0.04) and AI (β=4.41, P=0.07) remained associated with greater frequency of tension-type headache.

Conclusions: Higher central AI and AP, but not aortic stiffness, is associated with tension-type headache but not migraine in obese middle-aged/older adults. Whether excessive penetration of pulsatile pressure into cerebral microcirculation contributes to the development of tension-type or migraine headache in obesity requires further study.

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Journal
Artery Research
Volume-Issue
8 - 4
Pages
175 - 176
Publication Date
2014/11/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2014.09.033How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Grazi Kalil
AU  - Ana Recober
AU  - William G. Haynes
AU  - M. Bridget Zimmerman
AU  - Gary L. Pierce
PY  - 2014
DA  - 2014/11/04
TI  - PO-27 HIGHER CENTRAL AUGMENTATION PRESSURE/INDEX IS ASSOCIATED WITH TENSION-TYPE HEADACHE BUT NOT MIGRAINE IN MIDDLE-AGED/OLDER OBESE HUMANS
JO  - Artery Research
SP  - 175
EP  - 176
VL  - 8
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2014.09.033
DO  - 10.1016/j.artres.2014.09.033
ID  - Kalil2014
ER  -