Artery Research

Volume 8, Issue 4, December 2014, Pages 156 - 156

P9.11 ANGIOTENSIN-CONVERTING ENZYME ACTIVITY IN NORMOTENSIVE WHITE AND AFRICAN MEN

Authors
J. Van Rooyena, M. Poglitschb, R. Schuttea, H. Huismana, L. Malana, C. Fouriea, C. Melsa, W. Smitha, R. Krugera, N. Malana, A. Schuttea
aNorth-West University and HART, Potchefstroom, South Africa
bAttoquant Diagnostics, Vienna, Austria
Available Online 4 November 2014.
DOI
10.1016/j.artres.2014.09.199How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: The renin-angiotensin system (RAS) is a proteolytic cascade which consists of multiple enzymes and effector peptides. Angiotensin-Converting Enzyme (ACE) is one of the major enzymes in the RAS and catalyzing the decapeptide Angiotensin I to the octapeptide Angiotensin II. There are other non-RAS effects of ACE like mediating and/or modulating inflammation. We aimed to explore the ACE activity in white and black South African men and establish the associations with a marker of inflammation.

Methods: In a bi-ethnic sample (n=30) consisting of white and African men, the RAS-Fingerprinting was determined with LC-MS/MS quantification of Angiotensin peptides. Blood pressure and other variables were determined with known methods. Soluble urokinase Plasminogen Activator Receptor (suPAR) levels were determined using the suPARnostic® ELISA kit.

Results: From the RAS-Fingerprinting and ACE activity (product-substrate ratio) it is evident that ACE activity is significantly lower in the normotensive African men compared to white men. The higher ACE activity found in the white men associated positively with reactive oxygen species (ROS) (r=0.59; p=0.02) and with suPAR (r=0.63; p=0.01) but not in the African men.

Conclusions: The ACE activity is higher in the white men and it seems that ACE may drive inflammation only in the white participants.

Journal
Artery Research
Volume-Issue
8 - 4
Pages
156 - 156
Publication Date
2014/11/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2014.09.199How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - J. Van Rooyen
AU  - M. Poglitsch
AU  - R. Schutte
AU  - H. Huisman
AU  - L. Malan
AU  - C. Fourie
AU  - C. Mels
AU  - W. Smith
AU  - R. Kruger
AU  - N. Malan
AU  - A. Schutte
PY  - 2014
DA  - 2014/11/04
TI  - P9.11 ANGIOTENSIN-CONVERTING ENZYME ACTIVITY IN NORMOTENSIVE WHITE AND AFRICAN MEN
JO  - Artery Research
SP  - 156
EP  - 156
VL  - 8
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2014.09.199
DO  - 10.1016/j.artres.2014.09.199
ID  - VanRooyen2014
ER  -