Objective: This cross-sectional study was conducted to examine whether the risk profile for cardiovascular disease (CVD) and central hemodynamics, an independent marker for CVD, are not worsened in cancer survivors (CanS), who have annual health check-up, as compared to age-adjusted subjects without cancer (SWC).

Design: A cross-sectional cohort study.

Setting: Japan

Participants: From June 1, 2006, through November 30, 2007, Japanese subjects (4813 men and 3500 women) who had annual health check-up at the Health Care Center of Tokyo Medical University.

Main Outcomes and Measures: The prevalence rate of subjects quit smoking, hypertension, diabetes mellitus, hypercholesterolemia, and metabolic syndrome. Radial augmentation index (rAI) and the second peak of radial pressure wave form (SP2), marker of central hemodynamics

Results: In both genders, the age-adjusted prevalence rate of hypertension and that of metabolic syndrome were lower in the CanS (127 men and 127 women) than in the SWC (p < 0.05). These variables were significant determinants for the elevation of SP2. Then, age-adjusted SP2 was also lower in the CanS (109.2 mmHg) than in the SWC (110.4 mmHg)(p < 0.05).

Conclusions and Relevance: In Japanese male and female CanS who have annual health check-up, the risk profiles for CVD were not worsened and might be rather preferable as compared to SWC. Such preferable profiles might provide beneficial effects on central hemodynamics especially in male survivors. Thus, in Japan, CanS with the mind and condition to have annual health check-up may have rather preferable pathophysiological profiles with the prevention of CVD.