Artery Research

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Volume 5, Issue 4, December 2011, Pages 193 - 193

P11.03 AORTIC STIFFNESS INDICES IN FIRST-EVER AND RECURRENT ISCHEMIC STROKE – A PRELIMINARY REPORT

Authors
D. Gasecki1, A. Rojek2, M. Kwarciany1, K. Kowalczyk1, P. Boutouyrie3, W.M. Nyka1, S. Laurent3, K. Narkiewicz2
1Dept. of Neurology for Adults, Medical University of Gdańsk, Gdańsk, Poland
2Hypertension Unit, Dept. of Hypertension and Diabetology, Medical University of Gdańsk, Gdańsk, Poland
3Dept. of Pharmacology, Université Paris Descartes, INSERM U970, HEGP Assitance Publique Hôpitaux de Paris, Paris, France
Available Online 29 November 2011.
DOI
10.1016/j.artres.2011.10.159How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: Patients with acute ischemic stroke have higher aortic stiffness estimated by carotid-femoral pulse wave velocity (CF-PWV) and central augmentation index (cAIx) than control hypertensives. Whether CF-PWV and cAIx may distinguish patients with first-ever (FES) from those with recurrent ischemic stroke (RS) is unknown.

The aim of the study was to evaluate CF-PWV and cAIx in patients with the FES and RS as compared to control hypertensives, and to evaluate the relationship between these indexes and other clinical variables.

Methods: We studied 113 patients (82 males, 62.9±12.7yrs) with acute ischemic stroke, including 17 subjects with RS (13 males, 67.6±10.8yrs) and 71 controls (52 males, age 62.7±12.6yrs).CF-PWV, and cAIx were measured (SphygmoCor®) one week after stroke onset. Data were analysed with multivariate analysis.

Results: The mean CF-PWV was significantly higher in both RS and FES than in controls (12.5±3.5 vs. 8.6±1.3m/s, P<0.00001, and 10.2±2.8 vs. 8.6±1.3m/s, P=0.004 respectively). Moreover, the mean CF-PWV was significantly higher in RS compared to FES (12.5±3.5 vs. 10.0±2.8m/s, P=0.01). cAIx in RS (32.3±14.3mmHg) was similar to that in FES (28.5±11.7mmHg, P=0.49), but it was significantly higher compared to controls (25.2±10.3mmHg, P=0.02). In multivariate logistic regression analysis, higher CF-PWV remained significant after adjustment for age, SBP or HR, separately (Table).

Model OR 95% CI P value
Model 1 (R2=0.02)
Age 1.01 0.96 – 1.07 0.65
CF-PWV 1.23 1.01 – 1.50 0.04
Model 2 (R2=0.12)
SBP 0.97 0.93 – 1.01 0.1
CF-PWV 1.45 1.12 – 1.89 0.005
Model 3 (R2=0.08)
HR 1.01 0.96 – 1.06 0.75
CF-PWV 1.24 1.04 – 1.47 0.02

Conclusion: CF-PWV is higher in patients with recurrent stroke than in those with first-ever event independently of age and BP levels. These findings suggest that aortic stiffness might be implicated in progression of cerebrovascular disease in post-stroke patients.

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Journal
Artery Research
Volume-Issue
5 - 4
Pages
193 - 193
Publication Date
2011/11/29
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2011.10.159How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - D. Gasecki
AU  - A. Rojek
AU  - M. Kwarciany
AU  - K. Kowalczyk
AU  - P. Boutouyrie
AU  - W.M. Nyka
AU  - S. Laurent
AU  - K. Narkiewicz
PY  - 2011
DA  - 2011/11/29
TI  - P11.03 AORTIC STIFFNESS INDICES IN FIRST-EVER AND RECURRENT ISCHEMIC STROKE – A PRELIMINARY REPORT
JO  - Artery Research
SP  - 193
EP  - 193
VL  - 5
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2011.10.159
DO  - 10.1016/j.artres.2011.10.159
ID  - Gasecki2011
ER  -