P11.08 THE COMPARISON OF ENOS MUTATION 894G>T AND ITS RELATIONSHIP WITH ARTERIAL STIFFNESS

A. Cozma; A.V. Sitar taut; O.H. Orasan; L.M. Procopciuc; D. Pop; D.T. Zdrenghea

doi:10.1016/j.artres.2011.10.164

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Volume 5, Issue 4, December 2011, Pages 194 - 194

P11.08 THE COMPARISON OF ENOS MUTATION 894G>T AND ITS RELATIONSHIP WITH ARTERIAL STIFFNESS

Authors

A. Cozma¹, A.V. Sitar taut², O.H. Orasan¹, L.M. Procopciuc¹, D. Pop¹, D.T. Zdrenghea¹

¹“Iuliu Hatieganu” University of Medicine and Farmacy, Cluj Napoca, Romania

²“Babes Bolyai” University, Cluj Napoca, Romania

Available Online 29 November 2011.

DOI: 10.1016/j.artres.2011.10.164 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Acknowledgement: Grant ID 2246/2009

Background: Pulse wave velocity is a strong predictor of cardiovascular events and mortality. It is known that NO can influence arterial stiffness through vascular tone regulation. The presence of eNOS mutations can influence arterial stiffness. Purpose of the study was to investigate the relation between 894G>T mutation and arterial stiffness.

Material and method: The study included 70 subjects (63.4% women), in whom the 894G>T polymorphism (the PCR method) and arterial stiffness (using the TensioMedTMArteriograph) were determined. The mean age of the subjects was 59.81± 11.01 years, without significant sex differences.

Results: The distribution depending on the presence of genotypes was for the 894GT mutation as follows: 42.3% of the subjects were negative (GG), 40.8% heterozygous (GT) and 16.9% homozygous (TT). No significant differences were found between sexes (women vs men) regarding the presence of genotypes: GG 44.4% vs 38.5%, GT 44.4% vs 34.6%, TT 11.1 vs 26.9%, p=NS. Globally, there was no significant difference of the PWVAo values between homozygous and heterozygous or negative patients: 9.6±1.53m/sec in TT patients vs 10.36 ±1.79m/sec in GT patients vs 10.10±1.98 m/sec in GG patients(p=NS). There were no significant differences between the values of Aixb, AixAo, PP according to GG vs GT vs TT genotype (generally or per sexes), but homozygous patients (TT) had higher Aixb, PP values, respectively.

Conclusion: In the present study, the presence of the TT homozygote state was not associated with the increase of PWVAo, but seems to determine Aixb and PP increases.

		Mean	Std. Deviation	95% Confidence Interval for Mean

				Lower Bound	Upper Bound
PWVAo	GG	10.10	1.98	9.32	10.87
	GT	10.36	1.79	9.67	11.04
	TT	9.60	1.53	8.56	10.63
Aixb	GG	−1.80	30.34	−13.13	9.52
	GT	3.65	29.79	−7.67	14.98
	TT	8.80	33.67	−13.81	31.43
AixAo	GG	34.22	17.95	27.51	40.92
	GT	40.52	16.26	34.33	46.70
	TT	35.72	18.66	23.86	47.58
PP	GG	52.20	12.71	47.45	56.94
	GT	54.82	15.38	48.97	60.68
	TT	56.25	14.09	47.29	65.20

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Journal: Artery Research
Volume-Issue: 5 - 4
Pages: 194 - 194
Publication Date: 2011/11/29
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2011.10.164 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - A. Cozma
AU  - A.V. Sitar taut
AU  - O.H. Orasan
AU  - L.M. Procopciuc
AU  - D. Pop
AU  - D.T. Zdrenghea
PY  - 2011
DA  - 2011/11/29
TI  - P11.08 THE COMPARISON OF ENOS MUTATION 894G>T AND ITS RELATIONSHIP WITH ARTERIAL STIFFNESS
JO  - Artery Research
SP  - 194
EP  - 194
VL  - 5
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2011.10.164
DO  - 10.1016/j.artres.2011.10.164
ID  - Cozma2011
ER  -

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