P8.12 GENETIC INFLUENCES ON THE RELATION BETWEEN EXHALED NITRIC OXIDE AND ARTERIAL STIFFNESS: A TWIN STUDY

D.L. Tarnoki; A.D. Tarnoki; E. Medda; L. Littvay; Z.S. Lazar; R. Cotichini; C. Fagnani; M.A. Stazi; L. Nisticó; F. Fanelli; C. Baracchini; G. Meneghetti; Gy. Jermendy; I. Preda; A. Lannert; A.A. Molnar; Z. Garami; R.G. Kiss; V. Berczi; I. Horvath

doi:10.1016/j.artres.2011.10.133

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Volume 5, Issue 4, December 2011, Pages 185 - 185

P8.12 GENETIC INFLUENCES ON THE RELATION BETWEEN EXHALED NITRIC OXIDE AND ARTERIAL STIFFNESS: A TWIN STUDY

Authors

D.L. Tarnoki¹, A.D. Tarnoki¹, E. Medda², L. Littvay³, Z.S. Lazar⁴, R. Cotichini², C. Fagnani², M.A. Stazi², L. Nisticó², F. Fanelli⁵, C. Baracchini⁶, G. Meneghetti⁶, Gy. Jermendy⁷, I. Preda⁸, A. Lannert⁹, A.A. Molnar⁸, Z. Garami¹⁰, R.G. Kiss⁸, V. Berczi¹, I. Horvath⁴

¹Department of Radiology and Oncotherapy, Budapest, Hungary

²Istituto Superiore Di Sanitá, Italian Twin Registry, Rome, Italy

³Central European University, Budapest, Hungary

⁴Department of Pulmonology, Semmelweis University, Budapest, Hungary

⁵Vascular and Interventional Radiology Unit, Department of Radiological Sciences, La Sapienza University of Rome, Rome, Italy

⁶Department of Neurosciences, School of Medicine, University of Padua, Padua, Italy

⁷Bajcsy Zsilinszky Hospital, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary

⁸Research Group for Inflammation Biology and Immunogenomics of Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary

⁹School of Pharmacy, Semmelweis University, Budapest, Hungary

¹⁰The Methodist Hospital, DeBakey Heart and Vascular Center, Houston, United States of America

Available Online 29 November 2011.

DOI: 10.1016/j.artres.2011.10.133 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Objectives: Fractional exhaled nitric oxide (FE_NO) has an important physiological role in the airways and vessel walls.

Methods: 117 adult twin pairs were recruited in Hungary, Italy and in the United States (83 monozygotic and 34 dizygotic pairs; age 48±16 years). FE_NO was measured by an electrochemical sensor-based device and markers of arterial stiffness (augmentation index on brachial artery, Aix_bra and on aorta, Aix_ao; Pulse Wave Velocity on aorta, PWV_ao) by oscillometric method (TensioMed Arteriograph, TensioMed Ltd., Budapest). Bivariate Cholesky decomposition models were applied.

Results: Genetic effects accounted for 59% (95% confidence interval [CI]: 43, 71%) of the variation in FE_NO with the remaining 41% (95%CI: 29, 57%) due to non-shared environmental influences. Significant correlation was observed between FE_NO and Aix_bra (r=−0.20, 95% CI:−0.34,−0.05), or Aix_ao (r=−0.19, 95%CI:−0.33,−0.05). No significant correlation was found between FE_NO and PWV_ao. Genetic factors explained the entire phenotypic correlation between FE_NO and Aix_bra or FE_NO and Aix_ao. FE_NO showed a significant negative genetic correlation with Aix_bra and Aix_ao (r_g=−0.29, 95%CI:−0.49,−0.07).

Conclusions: Variations in FE_NO are explained by genetic and non-shared environmental effects. Covariances between FE_NO and Aix_bra or Aix_ao are explained entirely by genetic factors suggesting a remarkable overlap among the sets of genes involved in the expression of these phenotypes and providing a basis for further studies on cardiovascular and respiratory diseases.

(The research was supported by Medexpert Ltd, Twins Days Festival Committee, Balassa Institute Hungarian Scholarship Board Office, Ministry for Foreign Affairs of Republic of Italy.)

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Journal: Artery Research
Volume-Issue: 5 - 4
Pages: 185 - 185
Publication Date: 2011/11/29
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2011.10.133 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - D.L. Tarnoki
AU  - A.D. Tarnoki
AU  - E. Medda
AU  - L. Littvay
AU  - Z.S. Lazar
AU  - R. Cotichini
AU  - C. Fagnani
AU  - M.A. Stazi
AU  - L. Nisticó
AU  - F. Fanelli
AU  - C. Baracchini
AU  - G. Meneghetti
AU  - Gy. Jermendy
AU  - I. Preda
AU  - A. Lannert
AU  - A.A. Molnar
AU  - Z. Garami
AU  - R.G. Kiss
AU  - V. Berczi
AU  - I. Horvath
PY  - 2011
DA  - 2011/11/29
TI  - P8.12 GENETIC INFLUENCES ON THE RELATION BETWEEN EXHALED NITRIC OXIDE AND ARTERIAL STIFFNESS: A TWIN STUDY
JO  - Artery Research
SP  - 185
EP  - 185
VL  - 5
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2011.10.133
DO  - 10.1016/j.artres.2011.10.133
ID  - Tarnoki2011
ER  -

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