P7.04 AORTIC STIFFNESS IS ASSOCIATED WITH ALBUMINURIA IN THE GENERAL POPULATION
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Background: Albuminuria has been associated with increased cardiovascular risk. We hypothesised that this may be mediated through increased central arterial stiffness and subsequent transmission of pulsatile strain to the renal microvasculature.
Methods: In a prospective community cohort of 850 caucasians, albumin: creatinine ratio (ACR) was measured from random urine samples. Routine bloods were checked for biochemistry. Arterial stiffness was measured through aortic pulse wave velocity (aPWV) and wave reflections through augmentation index (AIx; SphygmoCor, Sydney). Albuminuria was classified by normal (1=<3.4 mg/mmol), mild (2=3.4–5.6 mg/mmol) and significant (3=6.8–166.7 mg/mmol).
Findings: (See table) A stepwise increase in aPWV with ACR category was seen in men but not women. This association not evident with AIx. Among Caucasian men, in multivariate analysis, eGFR and brachial pulse pressure were independently associated with albuminuria (R2 = 0.31, p < 0.001). Age, smoking, AIx and aPWV were not retained in the model.
Conclusions: In this cross-sectional study, a stepwise increase in PWV was seen with ACR. This relationship was not independent of confounding factors. Further studies are required to assess the influence of increased pulsatility in the renal microvasculature.
| Men (n=389) | Women (n=461) | |||||||
|---|---|---|---|---|---|---|---|---|
| ACR 1 | ACR 2 | ACR3 | P value | ACR 1 | ACR2 | ACR 3 | P value | |
| Age | 43±23 | 53±23 | 60±21 | < 0.001 | 44±21 | 38±23 | 42±22 | 0.22 |
| eGFR | 94±28 | 81±20 | 73±27 | < 0.001 | 90±21 | 90.8±21.7 | 80.2±21.7 | 0.12 |
| Chol | 4.4±0.9 | 4.1±0.9 | 4.1±0.9 | 0.65 | 4.8±1.1 | 4.8±1.1 | 4.4±1.3 | 0.17 |
| Diabetes | 5.2% | 4.8% | 9.1% | 0.84 | 3.5% | 4.8% | 0% | 0.52 |
| Smoker | 7.7% | 4.8% | 9.1% | 0.03 | 8.3% | 4.8% | 9.5% | 0.44 |
| SBP | 134±17 | 144±22 | 147±20 | <0.001 | 126±20 | 125±20 | 124±24 | 0.73 |
| DBP | 79±10 | 80±12 | 81±10 | 0.26 | 75±10 | 78±10 | 73±11 | 0.97 |
| AIx | 0.06±0.2 | 0.08±0.1 | 0.14±0.1 | 0.03 | 0.13±0.2 | 0.07±0.1 | 0.15±0.2 | 0.40 |
| aPWV | 7.8±2.7 | 9.0±3.1 | 9.4±3.0 | 0.002 | 7.3±2.5 | 7.2±2.7 | 7.5±3.1 | 0.93 |
Cite this article
TY - JOUR AU - V. Selvarajah AU - L.A. Tomlinson AU - J. Smith AU - Y. Yasmin AU - J.R. Cockcroft AU - I.B. Wilkinson AU - C.M. McEniery PY - 2011 DA - 2011/11/29 TI - P7.04 AORTIC STIFFNESS IS ASSOCIATED WITH ALBUMINURIA IN THE GENERAL POPULATION JO - Artery Research SP - 179 EP - 179 VL - 5 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2011.10.111 DO - 10.1016/j.artres.2011.10.111 ID - Selvarajah2011 ER -