Artery Research

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Volume 5, Issue 4, December 2011, Pages 139 - 140

1.5 AORTIC STIFFNESS IS INDEPENDENTLY ASSOCIATED WITH FATAL AND NON-FATAL CARDIOVASCULAR EVENTS IN CHRONIC KIDNEY DISEASE STAGE 2-5

Authors
A. Karras1, J.P. Haymann2, S. Laurent3, E. Bozec3, B. Stengel4, C. Jacquot1, P. Houillier5, M. Froissart5, P. Boutouyrie3, M. Briet3
1Department of Nephrology, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Université Paris 5, Paris, France
2Department of Physiology, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Paris, France
3Department of Pharmacology and Institut National de la Santé et de la Recherche Médicale U970, Hôpital Européen Georges, Paris, France
4Institut National de la Santé et de la Recherche Médicale U780, Université Paris-Sud, IFR 69, Villejuif, France
5Department of Physiology and Institut National de la Santé et de la Recherche Médicale U872, Hôpital Européen Georges Po, Paris, France
Available Online 29 November 2011.
DOI
10.1016/j.artres.2011.10.211How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Objective: Chronic kidney disease (CKD) is characterized by a high cardiovascular risk. Subclinical damage to large arteries has been largely described in CKD and is mostly characterized by an increase in arterial stiffness and an outward remodeling of the carotid artery. However, the predictive value of arterial remodeling and stiffening for cardiovascular events and mortality is still debated in pre-dialysed CKD (stage 2–5).

Methods: 180 patients (mean age 59.6 ± 14 years) with CKD (mean mGFR 32 mL/min/1.73m2) were included in this longitudinal study. Patients underwent a yearly check-up including arterial evaluation (carotid-femoral pulse wave velocity (SphygmoCor®), carotid thickness, diameter and stiffness (Art-Lab system®) and GFR measurement with the 51Cr-EDTA clearance.

Results: During an average follow-up of 49 ± 16 months, 36 fatal or not fatal cardiovascular events occurred. In COX regression analyses, PWV was significantly associated with fatal and non fatal cardiovascular events (risk ratio for 1 SD 1.46 [1.04–2.04], P=0.02) independently of age, body mass index, proteinuria, measured glomerular filtration rate and mean blood pressure. By contrast carotid intima-media thickness and circumferential wall stress were not significantly associated with fatal and non fatal cardiovascular events.

Conclusion: This study provides the first direct evidence that aortic stiffness not arterial remodeling is an independent predictor of fatal and non-fatal cardiovascular events in patients with CKD stage 2–5.

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Journal
Artery Research
Volume-Issue
5 - 4
Pages
139 - 140
Publication Date
2011/11/29
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2011.10.211How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - A. Karras
AU  - J.P. Haymann
AU  - S. Laurent
AU  - E. Bozec
AU  - B. Stengel
AU  - C. Jacquot
AU  - P. Houillier
AU  - M. Froissart
AU  - P. Boutouyrie
AU  - M. Briet
PY  - 2011
DA  - 2011/11/29
TI  - 1.5 AORTIC STIFFNESS IS INDEPENDENTLY ASSOCIATED WITH FATAL AND NON-FATAL CARDIOVASCULAR EVENTS IN CHRONIC KIDNEY DISEASE STAGE 2-5
JO  - Artery Research
SP  - 139
EP  - 140
VL  - 5
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2011.10.211
DO  - 10.1016/j.artres.2011.10.211
ID  - Karras2011
ER  -