Cholesterol metabolism, endothelial dysfunction, and carotid artery stiffness in type 1 diabetes☆
Grant support: The study was supported by grants from KuopioUniversity Hospital (EVO 5031340 and 5031316), Finnish Cultural Foundation of Northern Savo, Academy of Finland (project numbers 126873 and 123579), and Yrjö Jahnsson Foundation.
- https://doi.org/10.1016/j.artres.2010.09.001How to use a DOI?
- Cholesterol metabolism, Endothelial function, Carotid artery stiffness, Desmosterol, Sitosterol, Type 1 diabetes
Background: Type 1 diabetes is associated with increased risk of cardiovascular diseases and altered metabolism of cholesterol. We studied whether the markers of arterial stiffness reflecting preclinical atherosclerosis are related to markers of cholesterol metabolism in type 1 diabetes.
Methods: In eighteen type 1 diabetes subjects aged from 20 to 56 years, serum squalene and non-cholesterol sterols were measured with gas–liquid chromatography, and carotid arterial stiffness (elastic and Young’s modulus, beta index, distensibility, and compliance), intima-media thickness (IMT), and brachial artery endothelial function (flow-mediated dilatation, FMD) were measured with ultrasound imaging.
Results: Variables of arterial stiffness were not related to serum lipids or HbA1c except Young’s modulus and compliance to triglycerides (r = 0.541 and r = −0.552, p < 0.05 for both, respectively). Stiffness of carotid artery was related to mean blood pressure (elastic modulus r = 0.590, distensibility r = −0.486, p < 0.05 for both). Stiffness of carotid artery was associated with serum desmosterol concentration, marker of cholesterol synthesis (e.g. compliance r = −0.600, p < 0.01), and with markers of cholesterol absorption (e.g. distensibility and sitosterol to cholesterol ratio r = 0.628, p < 0.01), and the associations between absorption markers and arterial stiffness remained significant after adjustment on age and mean blood pressure.
Conclusions: Carotid arterial stiffness was associated with markers of cholesterol metabolism, but not with serum lipid levels. Low absorption-high synthesis of cholesterol was related to increased arterial stiffness. Cholesterol metabolism seems to play a role in vascular health beyond serum lipids in type 1 diabetes.
- © 2010 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
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Cite this article
TY - JOUR AU - Timo Koponen AU - Maarit Hallikainen AU - Jukka Lipponen AU - Tiina Lyyra-Laitinen AU - Pasi A. Karjalainen AU - Mika P. Tarvainen AU - Chaiyasit Sittiwet AU - Tatu A. Miettinen AU - Tomi Laitinen AU - Helena Gylling PY - 2010 DA - 2010/09 TI - Cholesterol metabolism, endothelial dysfunction, and carotid artery stiffness in type 1 diabetes☆ JO - Artery Research SP - 8 EP - 14 VL - 5 IS - 1 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2010.09.001 DO - https://doi.org/10.1016/j.artres.2010.09.001 ID - Koponen2010 ER -