Large arteries and angiotensin II blockade in hypertension

DOI

10.1016/j.artres.2010.07.001How to use a DOI?

Keywords

Hypertension; Large arteries; Angiotensin

Abstract

Renin-angiotensin blockade has reduced cardiovascular morbidity and mortality in hypertensive subjects. Experimental studies have shown that this blockade acts primarily on vascular tone, causing quasi simultaneously a decrease in vascular resistance, an increase in large artery compliance and a change in endothelial function independent of blood pressure changes. In hypertensive models, the reduction of arterial hypertensive hypertrophy is proportional to blood pressure reduction while the reduction of collagen is responsible for the elasticity improvement and only dependent on angiotensin II. Molecular biology shows that, under the control of MAP-kinase, the major substratum of the action is the biochemical complex between the integrin alpha5 beta1 and its ligand fibronectin, both highly sensitive to mechanical pulsatility and effects on collagen fibers. Following the Reason study, numerous therapeutic trials in hypertension have shown not only the antihypertensive effect of this complex but also its impact on pulsatility and finally on central systolic and pulse pressure.

Copyright

© 2010 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.

Open Access

This is an open access article distributed under the CC BY-NC license.

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TY  - JOUR
AU  - Michel E. Safar
PY  - 2010
DA  - 2010/09/16
TI  - Large arteries and angiotensin II blockade in hypertension
JO  - Artery Research
SP  - 67
EP  - 74
VL  - 4
IS  - 3
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.07.001
DO  - 10.1016/j.artres.2010.07.001
ID  - Safar2010
ER  -