Inflammatory status, arterial stiffness and central hemodynamics in hypertensive patients with metabolic syndrome

DOI

10.1016/j.artres.2009.09.001How to use a DOI?

Keywords

Arterial stiffness; Central blood pressures; Wave reflections; Metabolic syndrome; Arterial hypertension; Inflammation

Abstract

Introduction: Inflammatory state is activated in metabolic syndrome and may explain part of the adverse prognosis of this entity. Arterial stiffness, central blood pressures and wave reflections are independent predictors of cardiovascular risk. This study investigates the relation between low-grade inflammation and arterial stiffness and central hemodynamics in patients with metabolic syndrome.

Methods: We studied 106 consecutive hypertensive patients with metabolic syndrome. Arterial stiffness was assessed by carotid-femoral (c-f) and carotid-radial (c-r) pulse wave velocity (PWV). Central blood pressures were evaluated by pulse wave analysis and heart rate corrected augmentation index (AIx₇₅) was used as a measure of wave reflections. White blood cell count (WBC), high sensitivity C-reactive protein (hsCRP) and fibrinogen were measured as inflammatory markers.

Results: In univariable analysis, PWVc-f correlated with both hsCRP (p<0.01) and fibrinogen (p<0.01), while PWVc-r correlated with hsCRP (p=0.05). Regarding central blood pressures, aortic SBP correlated positively with hsCRP (p<0.05) and marginally with fibrinogen (p=0.06) and WBC (p=0.08). Interestingly, no correlation was found between AIx₇₅ and any of these biomarkers. After adjustment for age, gender, smoking, mean arterial pressure, heart rate, waist circumference, glucose, total and HDL cholesterol, PWVc-f was independently related to hsCRP (p<0.001) and fibrinogen (p<0.01), while a marginal independent correlation was also found between PWVc-r and hsCRP (p=0.06). Furthermore, aortic PP independently associated with fibrinogen (p<0.05) whereas marginal associations demonstrated between aortic SBP and hsCRP and fibrinogen (p=0.06 for both).

Conclusion: Inflammatory status is related to arterial stiffness and central blood pressures (but not to augmentation index) in hypertensives with metabolic syndrome. These findings may have implications for increased cardiovascular risk in these patients.

Copyright

© 2009 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V.All rights reserved.

Open Access

This is an open access article distributed under the CC BY-NC license.

Download article (PDF)
View full text (HTML)

TY  - JOUR
AU  - Panagiota Pietri
AU  - Charalambos Vlachopoulos
AU  - Konstantinos Aznaouridis
AU  - Katerina Baou
AU  - Panagiotis Xaplanteris
AU  - Ioanna Dima
AU  - Gregory Vyssoulis
AU  - Christodoulos Stefanadis
PY  - 2009
DA  - 2009/10/28
TI  - Inflammatory status, arterial stiffness and central hemodynamics in hypertensive patients with metabolic syndrome
JO  - Artery Research
SP  - 115
EP  - 121
VL  - 3
IS  - 3
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.09.001
DO  - 10.1016/j.artres.2009.09.001
ID  - Pietri2009
ER  -