Genetic variation in the C-reactive protein gene and arterial stiffness: The Rotterdam Study

M.P.S. Sie; F.U.S. Mattace-Raso; I. Kardys; M.P.M. de Maat; A.G. Uitterlinden; A. Hofman; A.P.G. Hoeks; R.S. Reneman; R. Asmar; C.M. van Duijn; J.C.M. Witteman

doi:10.1016/j.artres.2008.10.002

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Volume 2, Issue 4, November 2008, Pages 148 - 155

Genetic variation in the C-reactive protein gene and arterial stiffness: The Rotterdam Study

Authors

M.P.S. Sie^a^{, b}, F.U.S. Mattace-Raso^a^{, b}, I. Kardys^a, M.P.M. de Maat^c, A.G. Uitterlinden^a^{, b}, A. Hofman^a, A.P.G. Hoeks^d, R.S. Reneman^e, R. Asmar^f, C.M. van Duijn^a, J.C.M. Witteman^a^{, *}

^aDepartment of Epidemiology & Biostatistics, Erasmus Medical Center, P.O. Box 2040, 3000 CA Rotterdam, the Netherlands

^bDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands

^cDepartment of Haematology, Erasmus Medical Center, Rotterdam, the Netherlands

^dDepartment of Biophysics (A.P.G.H.), Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands

^eDepartments of Physiology (R.S.R.), Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands

^fCardiovascular Institute, Paris, France

^*Corresponding author. Tel.: +31 10 708 7488; fax: +31 10 708 9382. E-mail address: j.witteman@erasmusmc.nl (J.C.M. Witteman).

Corresponding Author

J.C.M. Witteman

Received 30 May 2008, Revised 13 October 2008, Accepted 16 October 2008, Available Online 21 November 2008.

DOI: 10.1016/j.artres.2008.10.002 How to use a DOI?
Keywords: C-reactive protein; Polymorphism; Arterial stiffness; Pulse wave velocity; Distensibility coefficient; Pulse pressure
Abstract: Background and aim: Arterial stiffness increases with age and has been found to predict cardiovascular disease. C-reactive protein (CRP) is an inflammation marker and has been found to be associated with arterial stiffness and risk of cardiovascular disease. Genetic factors account for part of the variance in CRP level. We studied the association of the total common variation in the CRP gene by polymorphisms 1184 C/T, 2042 C/T, 2911 C/G and haplotypes with arterial stiffness within the Rotterdam study.

Methods: The study (n = 3615) was embedded in the Rotterdam Study, a prospective, population-based study among subjects aged 55 years and older. Associations of genotypes and haplotypes with CRP level and measures of arterial stiffness were examined using linear regression and analyses of variance. Measures of arterial stiffness included aortic pulse wave velocity, carotid distensibility and pulse pressure. Analyses were adjusted for age, sex, mean arterial pressure, heart rate, known cardiovascular risk factors and measures of atherosclerosis.

Results: CRP level was significantly associated with pulse wave velocity (p < 0.001) and pulse pressure (p < 0.05), also after adjusting for cardiovascular risk factors. CRP level was also associated with the 1184 C/T (T-allele: higher level), the 2042 C/T (T-allele: lower level) and 2911 C/G (G-allele: higher level) polymorphisms (all p < 0.001). Genotype and haplotype analyses showed no consistent associations of genetic variation with pulse wave velocity, carotid distensibility and pulse pressure.

Conclusions: No consistent associations of the CRP polymorphisms 1184 C/T, 2042 C/T, 2911 C/G and corresponding haplotypes were found with measures of arterial stiffness.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 2 - 4
Pages: 148 - 155
Publication Date: 2008/11/21
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2008.10.002 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - M.P.S. Sie
AU  - F.U.S. Mattace-Raso
AU  - I. Kardys
AU  - M.P.M. de Maat
AU  - A.G. Uitterlinden
AU  - A. Hofman
AU  - A.P.G. Hoeks
AU  - R.S. Reneman
AU  - R. Asmar
AU  - C.M. van Duijn
AU  - J.C.M. Witteman
PY  - 2008
DA  - 2008/11/21
TI  - Genetic variation in the C-reactive protein gene and arterial stiffness: The Rotterdam Study
JO  - Artery Research
SP  - 148
EP  - 155
VL  - 2
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2008.10.002
DO  - 10.1016/j.artres.2008.10.002
ID  - Sie2008
ER  -

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