Artery Research

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Volume 9, Issue C, March 2015, Pages 33 - 39

Clinical utility of digital volume pulse analysis in prediction of cardiovascular risk and the presence of angiographic coronary artery disease

Authors
Konstantinos Vakalisa, Aris Bechlioulisa, Katerina K. Naka, Konstantinos Pappas, Christos S. Katsouras, Lampros K. Michalis*
Department of Cardiology and Michaelidion Cardiac Center, University of Ioannina, Ioannina, 45110, Greece
a

These authors had equal contributions to the preparation of the manuscript.

*Corresponding author. Tel.: +30 26510 07710; fax: +30 26510 07865. E-mail address: lmihalis@cc.uoi.gr (L.K. Michalis).
Corresponding Author
Lampros K. Michalis
Received 15 September 2014, Accepted 21 October 2014, Available Online 6 December 2014.
DOI
10.1016/j.artres.2014.10.001How to use a DOI?
Keywords
Digital pulse volume; Arterial stiffness; Stiffness index; Pulse wave velocity; Coronary artery disease; Cardiovascular risk
Abstract

Background: Stiffness Index (SI), assessed by finger photoplethysmography (digital volume pulse analysis), has been suggested as a simple and easy measure of arterial stiffness. However, its potential association with cardiovascular risk and coronary artery disease (CAD) has been little studied. The aims of the study were to investigate the relation of SI with classical risk factors and established arterial stiffness indices and its ability to predict cardiovascular risk and the presence of angiographic CAD.

Methods: We enrolled 126 consecutive patients (mean age 61 years, 74% males) with suspected stable CAD undergoing diagnostic coronary angiography. Cardiovascular risk was assessed using Framingham risk score (FRS) and the European Heart score. Carotid-femoral (PWVcf) and carotid-radial (PWVcr) pulse wave velocity and augmentation index, using applanation tonometry, and SI using finger photoplethysmography, were measured in all patients.

Results: SI was positively correlated with PWVcr (p = 0.017) but not with PWVcf. Increased SI (R2 0.19, p < 0.001) was independently associated with higher diastolic blood pressure and male gender. Increased SI and PWVcf were associated with higher FRS and Heart score (p < 0.05 for all), while only higher PWVcf was associated with the presence of angiographic CAD (p = 0.007).

Conclusions: SI, easily derived using finger photoplethysmography, was related to classical risk factors and peripheral arterial rather than aortic stiffness. SI and PWVcf were the only vascular indices associated with cardiovascular risk, but only PWVcf was related to the presence of coronary atherosclerosis. Further research is needed to clarify the value of this useful index of arterial stiffness in risk stratification.

Copyright
© 2014 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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<Previous Article In Issue
Journal
Artery Research
Volume-Issue
9 - C
Pages
33 - 39
Publication Date
2014/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2014.10.001How to use a DOI?
Copyright
© 2014 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Konstantinos Vakalis
AU  - Aris Bechlioulis
AU  - Katerina K. Naka
AU  - Konstantinos Pappas
AU  - Christos S. Katsouras
AU  - Lampros K. Michalis
PY  - 2014
DA  - 2014/12/06
TI  - Clinical utility of digital volume pulse analysis in prediction of cardiovascular risk and the presence of angiographic coronary artery disease
JO  - Artery Research
SP  - 33
EP  - 39
VL  - 9
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2014.10.001
DO  - 10.1016/j.artres.2014.10.001
ID  - Vakalis2014
ER  -