Plasma Cathepsin L Level is Positively Associated with Arterial Stiffness in Geriatric Patients

DOI

10.2991/artres.k.191125.001How to use a DOI?

Keywords

Arterial stiffness; cathepsin L; geriatric patients

Abstract

Background: Cathepsin L (Cat L) is involved in the regulation of vascular aging processes. The aim of this study was to evaluate the relationship between plasma Cat L level and arterial stiffness marker through brachial-ankle pulse wave velocity (baPWV) in geriatric patients.

Methods: Cross-sectional study with 502 people were selected from a population of 2250 people aged over 65 years old, from three different basic health zones of Shanghai. Blood samples were collected, and the baPWV was measured with the SphygmoCor system. The geriatric patients with baPWV values >20 m/s were defined as the high arterial stiffness group.

Results: In total, 248 (49.4%) of the 502 geriatric patients in this study were in the high arterial stiffness group. The high arterial stiffness group were older (p = 0.006) and had higher prevalence of hypertension (p = 0.020), coronary heart disease (CHD) (p = 0.037), higher systolic blood pressure (SBP) (p = 0.018), pulse pressure (p = 0.017), plasma Cat L (p = 0.002) and logarithmically transformed C-reactive protein (p = 0.023) levels than those in the low arterial stiffness group. Multivariable forward stepwise regression analysis showed that Cat L (β = 0.418, p = 0.011) and hypertension (β = 0.217, p = 0.029) were associated with baPWV values in geriatric patients. Moreover, an increased plasma Cat L level (odds ratio (OR): 1.048; 95% confidence interval (CI): 1.043–1.169; p = 0.018) was an independent factor for arterial stiffness among the geriatric patients.

Conclusion: In this study, plasma Cat L level was positively correlated with arterial stiffness in geriatric patients.

Copyright

© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Jun Xu
AU  - Feng-Feng Pan
AU  - Chan-Chan Xu
AU  - Yuan Zhong
AU  - Ting-Jun Hu
AU  - Guo-Xiang Fu
PY  - 2019
DA  - 2019/12/04
TI  - Plasma Cathepsin L Level is Positively Associated with Arterial Stiffness in Geriatric Patients
JO  - Artery Research
SP  - 65
EP  - 69
VL  - 25
IS  - 1-2
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191125.001
DO  - 10.2991/artres.k.191125.001
ID  - Xu2019
ER  -