Artery Research
2994 articles
Short Communication
Carotid artery stiffness and cerebral pulsatility in children
Wesley K. Lefferts, Jacob P. DeBlois, Brooks B. Gump, Kevin S. Heffernan
Pages: 64 - 67
Case Study
Rare chest pain causes by right bronchial artery
Ching Chih Liu, Yuan Pin Hsu
Pages: 64 - 65
Conference Abstract
P.052 AN INTERLEUKIN-6 POLYMORPHISM DETERMINES CHANGES IN ARTERIAL STIFFNESS CAUSED BY ACUTE INFLAMMATION
I. Dima, C. Vlachopoulos, C. Vasiliadou, N. Ioakeimidis, P. Xaplanteris, D. Kardara, K. Baou, C. Stefanadis
Pages: 65 - 65
Conference Abstract
ARTERIAL STIFFNESS AS A RISK FACTOR FOR CEREBRAL VASCULAR LESIONS
Dariusz Gasecki
Pages: 65 - 65
Increased arterial stiffness, a biomarker of vascular aging, is a recognized subclinical organ damage, and may thus serve as predictor of cardiovascular disease. The predictive value of arterial stiffness is higher in patients with higher baseline cardiovascular risk, such as in patients with hypertension....
Conference Abstract
P13 ARHGEF1/RHOA SIGNALING PARTICIPATE IN AGEING-INDUCED ARTERIAL STIFFNESS AND HYPERCOAGULABILITY
Camille Rouillon, Nathalie Mercier, Patrick Lacolley, Gervaise Loirand, Véronique Regnault
Pages: 65 - 65
The RhoA signaling pathway is a master regulator of mechanostransduction and plasticity of vascular smooth muscle cells (VSMCs) that controls arterial stiffening. The RhoA exchange factor Arhgef1 is causally involved in the development of angiotensin II-dependent hypertension.
Our aim was to determine...
Conference Abstract
8.1 ARTERIAL STIFFNESS, BLOOD PRESSURE AND CARDIAC OUTPUT STUDY
Suzanne Holewijn, Erik Groot Jebbink, Wim Aengevaeren, Jasper Martens, Marcel Hovens, Michel Reijnen
Pages: 65 - 65
We are planning a prospective study in 200 patients with an abdominal artery aneurysm (AAA). Non-invasive measurements will be performed including tonometry-based pulse wave analysis (PWA) and pulse wave velocity (PWV), echocardiography, and 24-hour blood pressure measurements.
This study will provide...
Conference Abstract
P.053 AN INTERLEUKIN-6 POLYMORPHISM DETERMINES CHANGES IN ARTERIAL STIFFNESS CAUSED BY ACUTE INFLAMMATION
I. Dima, C. Vlachopoulos, C. Vasiliadou, P. Xaplanteris, N. Iokeimidis, K. Aznaouridis, K. Baou, C. Stefanadis
Pages: 65 - 65
Conference Abstract
CHILDHOOD DETERMINANTS OF ARTERIAL DYSFUNCTION CENTRAL AND PERIPHERAL BLOOD PRESSURE
Renate Oberhoffer
Pages: 65 - 65
Arterial Hypertension is one of the leading causes of death and disability worldwide. Measurement of peripheral brachial blood pressure using cuff sphygmomanometry belongs to the clinical routine assessment from childhood on. Based on age and length related reference values, it is widely accepted as...
Conference Abstract
P35 SOLUBLE RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS AND AGE-DEPENDENT ARTERIAL STIFFENING IN GENERAL POPULATION BASED PROSPECTIVE STUDY
Julius Gelžinský, Otto Mayer, Markéta Hronová, Petra Karnosová, Jitka Seidlerová, Jan Filipovský
Pages: 65 - 65
Background: Accumulation of advanced glycation end-products (AGEs) is one of pathophysiological processes, responsible for progressive stiffening of vessel wall. In contrast, soluble isoform of receptor for AGEs (sRAGE) act as “decoy” and physiological defense against circulating AGEs. We hypothesized...
Conference Abstract
8.3 QUANTIFYING HEART AND ARTERIAL CONTRIBUTIONS TO CENTRAL BLOOD PRESSURE IN SYSTOLE
Samuel Vennin, Ye Li, Marie Willemet, Henry Fok, Brian Clapp, Jordi Alastruey, Phil Chowienczyk
Pages: 65 - 65
Background: A recent study has shown that the central pressure waveform could be determined by a very small set of parameters accounting for the physical properties of the heart and the arteries [1]. Particularly, main pressure features like first systolic shoulder (P1) and systolic (P2) pressures were...
Conference Abstract
P.054 RELATIONSHIP BETWEEN, BLOOD VISCOSITY, SHEAR STRESS AND ARTERIAL STIFFNESS IN PATIENTS WITH ARTERIAL HYPERTENSION
M.W. Rajzer, M. Klocek, W. Wojciechowska, I. Palka, K.L. Kawecka-Jaszcz
Pages: 65 - 65
Conference Abstract
ARE CENTRAL HEMODYNAMIC PARAMETERS BETTER PROGNOSTIC MARKERS THAN PERIPHERAL BLOOD PRESSURE IN STROKE?
Alberto Avolio, Ernesto L. Schiffrin
Pages: 65 - 65
The complex pathophysiological mechanisms involved in stroke confound the associative and causal role of blood pressure. This is particularly relevant in monitoring changes in blood pressure with respect to treatment efficacy and stroke outcome, which is highly dependent on the both patient and stroke...
Conference Abstract
P36 PULSE PRESSURE AMPLIFICATION AND ITS RELATIONSHIP WITH AGE IN YOUNG, APPARENTLY HEALTHY BLACK AND WHITE ADULTS: THE AFRICAN-PREDICT STUDY
Yolandi Breet, Alta Schutte, Hugo Huisman, Ruan Kruger, Johannes van Rooyen, Lebo Gafane-Matemane, Lisa Ware
Pages: 65 - 65
Background: Pulse pressure amplification (PPA), i.e. the amplification from central arteries to the periphery, is inversely related to arterial stiffness, organ damage and mortality. It is known that arterial stiffness is higher in black than white populations, but it is unclear if this is due to early...
Conference Abstract
8.4 DIURNAL CHANGES IN CENTRAL PRESSURE AND PULSE WAVE PARAMETERS IN HEALTHY SUBJECTS
Bernhard Hametner, Christopher Mayer, Jelena Köster, Johannes Weber, Michael Reppel, Klaas Franzen, Eugenijus Kaniusas, Siegfried Wassertheurer, Kai Mortensen
Pages: 65 - 65
Purpose: The feasibility of pulse wave analysis (PWA) over 24 hours with oscillometric devices has already been shown and first studies indicate additional information compared to single measurements. Nevertheless, diurnal patterns of PWA parameters in healthy subjects, which can potentially serve as...
Conference Abstract
P.055 COMMON CAROTID ARTERY STIFFNESS: MORE SENSITIVE TO AGE AND GENDER RELATED LARGE ARTERY STIFFENING THAN AORTIC PULSE WAVE VELOCITY?
S.J. Vermeersch, E.R. Rietzschel, M.L. De Buyzere, D. De Bacquer, G. De Backer, L.M. Van Bortel, T.C. Gillebert, P.R. Verdonck, P. Segers
Pages: 65 - 65
Conference Abstract
THE HAEMODYNAMIC GENESIS OF HYPERTENSION
Phil Chowienczyk
Pages: 65 - 66
Hypertension has classically been attributed to an increase in peripheral vascular resistance. Such an increase in peripheral vascular resistance would increase mean and diastolic blood pressure but have little influence on pulse pressure. However, hypertension in our ageing society occurs mainly as...
Conference Abstract
P37 REFERENCE VALUES OF CARDIO-ANKLE VASCULAR INDEX IN A RANDOM SAMPLE OF A CAUCASIAN POPULATION
Peter Wohlfahrt, Renata Cífková, Narine Movsisyan, Šárka Kunzová, Jiří Lešovský, Martin Homolka, Vladimír Soška, Petr Dobšák, Francisco Lopez- Jimenez, Ondřej Sochor
Pages: 65 - 66
Objectives: Cardio-ankle vascular index (CAVI), a parameter of arterial stiffness, has been increasingly used for cardiovascular risk estimation. Currently used CAVI reference values are derived from the Japanese population. It is not clear whether the same reference values can be used in the Caucasian...
Conference Abstract
P.056 HERITABILITY OF ARTERIAL WALL INTIMA MEDIA THICKNESS IN DIFFERENT VASCULAR BEDS
V. Dzenkeviciute, L. Ryliskyte, A. Laucevicius, Z. Petrulioniene
Pages: 65 - 66
Research Article
Viscoelastic properties of the autologous bypass grafts: A comparative study among the small saphenous vein and internal thoracic artery
Arezoo Khosravi, Milad Salimi Bani, Hossein Bahreinizad, Alireza Karimi
Pages: 65 - 71
Internal thoracic artery (ITA) and small saphenous vein (SSV) are two viable conduits for coronary artery bypass grafts. The aim of this study was to investigate the viscoelastic behavior of the small saphenous vein and internal thoracic artery under compressive and tensile loadings at body temperature....
Research Article
Plasma Cathepsin L Level is Positively Associated with Arterial Stiffness in Geriatric Patients
Jun Xu, Feng-Feng Pan, Chan-Chan Xu, Yuan Zhong, Ting-Jun Hu, Guo-Xiang Fu
Pages: 65 - 69
Background: Cathepsin L (Cat L) is involved in the regulation of vascular aging processes. The aim of this study was to evaluate the relationship between plasma Cat L level and arterial stiffness marker through brachial-ankle pulse wave velocity (baPWV) in geriatric patients.
Methods: Cross-sectional...
Research Article
A systematic appraisal of ventricular–aortic load in African American men
Kevin S. Heffernan, Bo Fernhall
Pages: 65 - 72
Background: We examined several measures of ventricular–vascular load as they relate to ECG-derived measures of left ventricular (LV) morphology in a cross-section of 19 young African American and 19 white men.
Methods: Measures of steady and pulsatile LV load derived from aortic blood pressure waveforms...
Research Article
Aortic pulse wave velocity measured by pulse wave imaging (PWI): A comparison with applanation tonometry
Jonathan Vappou, Jianwen Luo, Kazue Okajima, Marco Di Tullio, Elisa Konofagou
Pages: 65 - 71
Background: Arterial stiffness is a well-established indicator of cardiovascular disease outcome. Pulse Wave Velocity (PWV) is a surrogate for arterial stiffness that is measured either globally using carotid-to-femoral applanation tonometry or locally using biomedical imaging methods. Pulse Wave Imaging...
Research Article
White blood cell count and endothelin-1 vasoconstrictor tone in middle-aged and older adults
Kyle J. Diehl, Brian R. Weil, Jared J. Greiner, Brian L. Stauffer, Christopher A. DeSouza
Pages: 65 - 70
Background: Higher white blood cell (WBC) count is associated with impaired endothelium-dependent vasodilation. However, the influence of higher WBC count on endothelin (ET)-1 vasoconstrictor activity is currently unknown. We tested the hypothesis that adults with elevated WBC count demonstrate enhanced...
Review Article
Magnetic Resonance Imaging for Aortic Function Evaluation in Thoracic Aortic Aneurysms
Andrea Guala, Gisela Teixido-Turá, Arturo Evangelista, Jose Rodriguez-Palomares
Pages: 65 - 70
Thoracic aortic aneurysm is a common cardiovascular disease consisting of marked dilation of the aorta. Aortic aneurysms carry a high risk of life-threatening complications such as aortic dissection or rupture. Classically, maximum aortic diameter has been used as the sole descriptor of aneurysm severity...
Conference Abstract
P.057 AORTIC DISTENSIBILITY BY NUCLEAR MAGNETIC RESONANCE IN ESENTIAL HYPERTENSION
C. Giannattasio, S. Maestroni, E. Fantini, M. Amigoni, M. Rigoldi, F. Zerbini, A. Capra, M. Failla, S. Sironi, G. Mancia
Pages: 66 - 66
Conference Abstract
P38 ASCENDING AORTA DIMENSIONS AND CLINIC AND 24 HOURS BLOOD PRESSURE IN A GENERAL POPULATION IN NORTHERN ITALY: THE VOBARNO STUDY
Anna Paini, Massimo Salvetti, Fabio Bertacchini, Deborah Stassaldi, Claudia Agabiti Rosei, Carlo Aggiusti, Giulia Rubagotti, Giulia Maruelli, Chiara Arnoldi, Enrico Agabiti Rosei, Maria Lorenza Muiesan
Pages: 66 - 66
Conference Abstract
8.5 HEMODYNAMICS DURING INTRA- AND INTERDIALYTIC PERIODS DEPEND ON ULTRAFILTRATION VOLUME
Christopher Mayer, Stephan Geilert, Julia Matschkal, Uwe Heemann, Marcus Baumann, Christoph Schmaderer
Pages: 66 - 66
Introduction: Parameters of arterial stiffness are independent cardiovascular risk factors for end-stage renal disease patients. Significant changes of these parameters between intra- and interdialytic periods have been reported previously [1]. The aim of this cross-sectional study is to describe the...
Conference Abstract
P.058 ENDOTHELIAL DYSFUNCTION AS MEASURED BY FLOW MEDIATED DILATATION (FMD) IN CARDIOVASCULAR RISK ASSESSMENT
S. Holewijn, J. de Graaf, M. den Heijer, A.F.H. Stalenhoef
Pages: 66 - 66
Conference Abstract
P39 LEFT VENTRICULAR STRUCTURE AND FUNCTION IN RELATION TO PERIPHERAL AND CENTRAL BLOOD PRESSURE IN A GENERAL POPULATION
Wenyi Yang, Ljupcho Efremov, Zhen-Yu Zhang, Nicholas Cauwenberghs, Lutgarde Thijs, Fang-Fei Wei, Qi-Fang Huang, Blerim Mujaj, Aernout Luttun, Peter Verhamme, Tatiana Kuznetsova, Jan Staessen
Pages: 66 - 66
Background: Central blood pressure (BP) is a predictor of target organ damage. No previous study addressed the question to what extent central compared with peripheral is related to left ventricular (LV) structure and function in a general population.
Methods: In 577 Flemish recruited from the general...
Conference Abstract
8.6 AEROBIC FITNESS LEVEL AND PERIPHERAL ARTERIAL COMPLIANCE – THE ROLE OF AUTONOMIC NERVOUS SYSTEM TONE
Nejka Potocnik, Ziva Melik, Ksenija Cankar, Martin Strucl
Pages: 66 - 66
Physical activity has beneficial effects on prevention of cardiovascular disease. Aerobic fitness is associated with higher central arterial compliance, but its effect on peripheral arterial compliance (pC) is controversial. We aimed to test the hypotheses that aerobic training augments pC at rest and...
Conference Abstract
P.059 IS INCREASED SYSTOLIC BLOOD PRESSURE THE MAIN REASON FOR CARDIOVASCULAR DISEASES?
Z. Melik, K. Cankar, N. Potocnik
Pages: 66 - 66
Conference Abstract
P40 DOES ARTERIAL AGEING DIFFER BETWEEN EUROPEANS AND JAPANESE AND KOREAN PATIENT SAMPLES? RESULTS FROM CURRENT UK STUDIES
F.A. Kirkham, C. Mills, K. Nambiar, J. Timeyin, K.A. Davies, F. Kern, J.K. Cruickshank, C. Rajkumar
Pages: 66 - 67
Objective: Vascular stiffness has long been linked with the ageing process. However, it is only since the development of accurate methods for measuring arterial compliance that unravelling this relationship has become possible. Arterial stiffening over time appears to differ between ethnic groups and/or...
Conference Abstract
8.7 CHANGES IN CARDIAC FUNCTION BUT NOT STRUCTURE IN HEALTHY SUBJECTS WITH PREMATURE VASCULAR AGEING
Oscar Mac Ananey, Vincent Maher
Pages: 66 - 67
Purpose: Changes in myocardial and arterial wall properties/function are consistently reported in patients with established cardiovascular disease1. However, few studies have reported these changes in early subclinical disease. The aim of the present study was to examine cardiac and vascular changes...
Conference Abstract
P.060 BAROREFLEX SENSITIVITY AND THE QUALITY OF BLOOD PRESSURE REGULATION
K. Cankar, Z. Melik, N. Potocnik
Pages: 66 - 67
Review Article
Should a statin be given to all hypertensive patients?
Harry Struijker-Boudier
Pages: 66 - 68
Statins have become an essential treatment for primary and secondary prevention of cardiovascular risk. This has been firmly established for patients with a relatively high risk for cardiovascular complications. Recent studies, in particular the HOPE trial, has extended this observation to patients with...
Mini Review
Cardiovascular aging: Insights from local and regional measures of aortic stiffness using magnetic resonance imaging
Alban Redheuil
Pages: 66 - 72
Aortic stiffness is now established as an independent marker of cardiovascular aging and cardiovascular risk. However, the specific role of the proximal aorta, specifically the ascending aorta, remains understudied. Magnetic resonance imaging (MRI), a non-invasive technique has recently been proposed...
Conference Abstract
P.061 A HAPLOTYPE AT THE MMP-9 LOCUS IS ASSOCIATED WITH HIGHER BLOOD PRESSURE AND GREATER ARTERIAL STIFFNESS IN PATIENTS WITH ESSENTIAL HYPERTENSION
A. Mahmud, S. Zhou, P. Jerrard-Dunne, J. Spiers, J. Feely
Pages: 67 - 67
Conference Abstract
1.1 PROMOTION OF ARTERIAL STIFFNESS BY CHILDHOOD CANCER AND ITS CHARACTERISTICS IN ADULT LONG-TERM SURVIVORS
Natalie Arnold, Hiltrud Merzenich, Arthur Wingerter, Andreas Schluz, Astrid Schneider, Jürgen H. Prochaska, Sebastian Göbel, Marie-Astrid Neu, Nicole Henninger, Marina Panova-Noeva, Susan Eckerle, Claudia Spix, Irene Schidtmann, Karl J. Lackner, Manfred E. Beutel, Norbert Pfeiffer, Thomas Münzel, Jörg Faber, Philipp S. Wild
Pages: 67 - 67
Background: Vascular alterations induced by antineoplastic treatment might be considered as a possible underlying mechanism of increased cardiovascular (CV) sequelae in childhood cancer survivors (CCS). Therefore, we thought to evaluate the changes in arterial stiffness (AS) among long-term CCS compared...
Conference Abstract
P41 MYOCARDIAL MECHANOENERGETIC EFFICIENCY INDEX (MMEI) AND ARTERIAL STIFFNESS: ASSOCIATION IN A GENERAL POPULATION IN NORTHER ITALY
Fabio Bertacchini, Massimo Salvetti, Anna Paini, Giulia Rubagotti, Deborah Stassaldi, Carlo Aggiusti, Giulia Maruelli, Chiara Arnoldi, Giovanni Saccà, Enrico Agabiti Rosei, Maria Lorenza Muiesan
Pages: 67 - 67
A non-invasive approach for the estimation of mechanical efficiency through the calculation of the ratio between stroke work and HR-pressure product has been recently proposed by de Simone et al. This index, which expresses the amount of blood pumped in a single beat in 1 second by the heart, may be...
Conference Abstract
8.8 SYMPATHETIC VASOCONSTRICTOR RESPONSE TO LOWER BODY NEGATIVE PRESSURE IN YOUNG OBESE ADULTS: THE PRELIMINARY FINDING
Kanokwan Bunsawat, Georgios Grigoriadis, Bo Fernhall, Tracy Baynard
Pages: 67 - 67
Background: Elevations in muscle sympathetic nerve activity (MSNA) and sympathetic vasoconstrictor responsiveness to sympathoexcitation are associated with increased cardiovascular risks, which affect hemodynamics, and have been reported in obese adults with metabolic syndrome (1–3). It remains unclear...
Conference Abstract
P.062 ADIPONECTIN GENE POLYMORPHISM -276G>T CONTRIBUTES TO ARTERIAL STIFFNESS IN ESSENTIAL HYPERTENSION
S. Zhou, J. Feely, P. Jerrard-Dunne, J. Spiers, A. Mahmud
Pages: 67 - 67
Conference Abstract
1.2 ASSOCIATIONS BETWEEN INDICATORS OF CARDIOVASCULAR DISEASE AND PULSE WAVE ANALYSIS AND VELOCITY: A COMPARISON OF DEVICES
Elizabeth Ellins, Lucy Lennon, Olia Papacosta, Goya Wannamethee, Peter Whincup, Julian Halcox
Pages: 67 - 67
Background: Both the Sphygmocor (S) and Vicorder (V) devices can be used for Pulse Wave Analysis (PWA) and Velocity (PWV). We investigated if there were differences in the associations between markers of Cardiovascular Disease (CVD) and PWA and PWV variables as assessed by the two devices.
Methods:...
Conference Abstract
P42 24-HOUR CENTRAL BLOOD PRESSURE IS MORE STRONGLY ASSOCIATED TO TARGET ORGAN DAMAGE THAN BRACHIAL BLOOD PRESSURE: FIRST RESULTS OF THE VASOTENS REGISTRY
Stefano Omboni, Igor N. Posokhov, Gianfranco Parati, Vitaliy S. Barkan, Ernesto Cardona Muñoz, Elena A. Grigoricheva, Irina E. Minyukhina, Maria Lorenza Muiesan, Giuseppe Mulè, Iana A. Orlova, Telmo Pereira
Pages: 67 - 68
Objective: In the present analysis of the VASOTENS study [1] baseline data, we checked whether organ damage of hypertension (TOD) i) is better associated with 24-hour central than peripheral BP and ii) is related to ambulatory arterial stiffness, estimated by pulse wave velocity (PWV) and augmentation...
Conference Abstract
8.9 REDUCTION IN MYOCARDIAL WALL STRESS AND DELAYED MYOCARDIAL RELAXATION DURING EXERCISE
Haotian Gu, Xiaoli Zhang, Benyu Jiang, Sally Brett, Phil Chowienczyk
Pages: 67 - 67
Introduction: Myocardial wall stress (MWS) is thought to be the mechanical stimulus to ventricular hypertrophy (1,2). The objective of this study was to examine the effect of exercise on time-varying MWS (3).
Methods: Twelve subjects, aged 42.0 ± 16.8 (mean ± SD) years, systolic blood pressure (BP)...
Conference Abstract
P.063 INDUCIBLE NITRIC OXIDE SYNTHASE ACTIVITY IS ASSOCIATED WITH INCREASED AORTIC STIFFNESS AND ENDOTHELIAL DYSFUNCTION
K.M. Maki-Petaja, J. Cheriyan, F.C. Hall, S.M.L. Wallace, C.M. McEniery, I.B. Wilkinson
Pages: 67 - 67
Conference Abstract
1.3 PREDICTION OF CARDIOVASCULAR MORTALITY AND MORBIDITY IN THE MALMö DIET-CANCER COHORT FOR THE IDENTIFICATION OF HEALTHY VASCULAR AGEING, USING MARKERS OF VASCULAR STATUS
Benjamin Nilsson Wadström, Peter Nilsson, Abd Al-Hakim Fatehali, Gunnar Engstrom
Pages: 67 - 68
Background: This study aims to translate two arterial measurements, aortic Pulse Wave Velocity (aPWV) and carotid Intima-Media Thickness (cIMT), into a combined Vascular Ageing Index (VAI), to evaluate the predictive power of VAI and utilize it to identify a sub-group with Healthy Vascular Ageing (HVA).
Methods:...
Conference Abstract
8.10 BRACHIAL ARTERY FLOW-MEDIATED DILATATION: DIFFERENT PATTERNS OF WALL SHEAR RATE INCREASE DURING REACTIVE HYPERAEMIA
Kunihiko Aizawa, Sara Sbragi, Alessandro Ramalli, Piero Tortoli, Francesco Casanova, Carmela Morizzo, Clare Thorn, Angela Shore, Phillip Gates, Carlo Palombo
Pages: 67 - 68
Background: Wall shear rate (WSR) is considered an important stimulus for flow-mediated dilatation (FMD). However, its estimation by conventional ultrasound is challenging due to inherent difficulties of velocity estimation near the arterial wall. To evaluate how WSR influences brachial artery FMD, we...
Conference Abstract
P.064 AMBULATORY ARTERIAL STIFFNESS INDEX, PULSE WAVE VELOCITY AND AUGMENTATION INDEX–INTERCHANGEABLE OR MUTUALLY EXCLUSIVE MEASURES
A. Mahmud, P. Jerrard-Dunne, J. Feely
Pages: 67 - 67
Research Article
Effects of curcumin intake and aerobic exercise training on arterial compliance in postmenopausal women
Nobuhiko Akazawa, Youngju Choi, Asako Miyaki, Yoko Tanabe, Jun Sugawara, Ryuichi Ajisaka, Seiji Maeda
Pages: 67 - 72
Background: Reduction in arterial compliance with aging increases the risk of cardiovascular disease. Lifestyle modification, particularly aerobic exercise and dietary modification, has a favorable effect on vascular aging. Curcumin, a major component of turmeric, is an anti-inflammatory agent. Therefore,...
Review Article
Large arteries and angiotensin II blockade in hypertension
Michel E. Safar
Pages: 67 - 74
Renin-angiotensin blockade has reduced cardiovascular morbidity and mortality in hypertensive subjects. Experimental studies have shown that this blockade acts primarily on vascular tone, causing quasi simultaneously a decrease in vascular resistance, an increase in large artery compliance and a change...
Research Article
Canola oil decreases cholesterol and improves endothelial function in patients with peripheral arterial occlusive disease – a pilot study☆
Hans Stricker, Francesca Duchini, Marco Facchini, Giorgio Mombelli
Pages: 67 - 73
Background: Dietary supplementation with omega-3 PUFAs has been shown to reduce cardiovascular morbidity and mortality. This pilot study investigated the effects of supplementation with plant-derived omega-3 and omega-6 PUFAs in patients with atherosclerosis.
Methods: Forty patients with PAD supplemented...
Conference Abstract
P.066 PERIPHERAL VASCULAR DISEASE IS ASSOCIATED WITH INCREASED AORTIC STIFFNESS
S.M.L. Wallace, B. McDonnell, M. Munnery, K.M. Maki-Petaja, J. Cheriyan, C.M. McEniery, S. Hill, J. Cockcroft, K. Varty, I. Wilkinson
Pages: 68 - 68
Conference Abstract
1.4 PROGNOSTIC VALUE OF PROXIMAL AORTA LONGITUDINAL STRAIN IN MARFAN SYNDROME
Andrea Guala, Jose Rodríguez-Palomares, Aroa Ruiz-Muñoz, Minerva Gandara, Violeta Sanchez, Alberto Forteza, David Garcia-Dorado, Artur Evangelista, Gisela Teixido-Tura
Pages: 68 - 68
Background: Aortic root dilation and type A aortic dissection are the most common cardiovascular complications of Marfan syndrome (MFS). Current clinical management of MFS patients relies on a close follow-up of aortic root diameter and preventive aortic root surgery in case of severe or fast-progressing...
Conference Abstract
P45 RENIN AT DIFFERENT PHYSICAL ACTIVITY LEVELS IN A BI-ETHNIC POPULATION: THE AFRICAN-PREDICT STUDY
Johannes van Rooyen, Hugo Huisman, Leonè Malan, Catharina Mels, Ruan Kruger, Lebo Gafane-Matemane, Shani Botha, Alta Schutte
Pages: 68 - 68
Background and objectives: It is widely accepted that regular physical exercise reduces the BP, particularly in hypertensive individuals. It is recommended in the prevention of hypertension to assist in BP control. The BP lowering mechanisms of exercise remain largely elusive, we therefore evaluated...
Conference Abstract
8.11 CARDIO-ANKLE VASCULAR INDEX AND CAROTID-FEMORAL PULSE WAVE VELOCITY ARE CLOSELY ASSOCIATED WITH CHRONOLOGICAL AGE
L.B. Mendes, E. Bunting, K. Ali, J. Timeyin, C. Rajkumar
Pages: 68 - 68
Background: Vascular stiffening is part of the ageing process. However, it is not clear which vascular stiffness parameters are closely associated with chronological age.
Methods: Fifty-eight participants (38 men), age 69.57 ± 10.46 (mean ± SD, range = 47–90 years) who have had transient ischaemic attack...
Conference Abstract
P.067 EFFECTS OF INHIBITION OF AUTONOMIC NERVOUS SYSTEM ON AORTIC STIFFNESS FOLLOWING SYSTEMIC INFUSION OF GLYCERYL TRINITRATE IN HEALTHY VOLUNTEERS
S.M.L. Wallace, K.M. Maki-Petaja, E.H. Davidson, J. Cheriyan, J. Graggaber, C.M. Eniery, I.B. Wilkinson
Pages: 68 - 68
Conference Abstract
1.5 DEEP VASCULAR PHENOTYPING IN PATIENTS WITH FIBROMUSCULAR DYSPLASIA
Rosa Maria Bruno, Louise Marais, Hakim Khettab, Aurélien Lorthioir, Xavier Jeunemaitre, Stèphane Laurent, Pierre Boutouyrie, Michel Azizi
Pages: 68 - 68
Background: Fibromuscular dysplasia (FMD) is a non-atherosclerotic, non-inflammatory vascular disease involving medium-sized muscular arteries, whose pathophysiology is still unknown.
Objectives: We aimed at identifying systemic vascular alterations in usually non-affected arteries of patients with...
Conference Abstract
P68 THE HIDDEN PREDICTOR OF CARDIOVASCULAR OUTCOME
José Sousa, João Lopes, Liliana Reis, Marta Madeira, Carolina Lourenço, Lino Gonçalves
Pages: 68 - 68
Background: Hyperuricemia is common in patients with hypertension, diabetes and obesity. Whether it is an independent cardiovascular risk factor (CVRF) or not remains controversial.
Purpose: To determine the prognostic value of uricemia in the setting of acute coronary syndrome (ACS).
Methods: Retrospective...
Conference Abstract
P46 ARTERIAL STIFFNESS IN RELATION TO BIRTH CHARACTERISTICS IN THE JAMAICAN 1986 BIRTH COHORT
Nadia Bennett, Trevor Ferguson, Novie Younger-Coleman, Marshall Tulloch-Reid, Renee Walters, Amanda Rousseau, Janeil Williams, Seeromanie Harding, J. Kennedy Cruickshank, Rainford Wilks
Pages: 68 - 68
Background: We tested the association between birthweight and arterial stiffness measured by aortic pulse wave velocity (PWV) and cardio-ankle vascular index (CAVI) in a birth cohort of 30 year old Jamaicans.
Methods: Participants were from the 1986 Jamaica Birth Cohort. Arterial stiffness was measured...
Conference Abstract
9.1 ULTRASOUND CHARACTERIZATION OF CARDIOVASCULAR ALTERATIONS IN YOUNG OB/OB MICE
Nicole Di Lascio, Claudia Kusmic, Francesco Stea, Francesco Faita
Pages: 68 - 68
Obesity is associated with diabetes and an increased cardiovascular risk. Leptin-deficient mice (ob/ob) are used as model of metabolic disease: they are characterized by obesity and insulin-resistance. Aim of this work is to identify early cardiovascular alterations in young ob/ob mice using micro-ultrasound...
Conference Abstract
P.068 A NON-INVASIVE APPROACH TO QUANTIFY VENTRICULAR-ARTERIAL INTERACTION: COMPARING VASCULAR TYPE EHLERS-DANLOS SYNDROME PATIENTS AND NORMAL INDIVIDUALS
K.D. Reesink, E. Hermeling, K.T. Ong, P. Boutouyrie, A.P.G. Hoeks
Pages: 68 - 68
Conference Abstract
1.6 AORTIC PULSE WAVE VELOCITY IN PORTUGUESE CHILDREN AND ADOLESCENTS – RESULTS FROM THE PORTUGUESE VASCULAR PHENOTYPE IN CHILDREN AND ADOLESCENTS (PORT-VASPH) COHORT
Telmo Pereira, João Maldonado, Margarida Carvalho
Pages: 68 - 69
Introduction: The PORT-VASPh Cohort was designed to contribute to a better understanding of vascular function in children and adolescents, mostly focusing PWV and other complementary aspects of arterial hemodynamics.
Methods: The PORT-VASPh cohort is a prospective and observational study, with 953 children...
Conference Abstract
P47 TETRAHYDROBIOPTERIN AND MARKERS OF OXIDATIVE STRESS IN A YOUNG BI-ETHNIC POPULATION: THE AFRICAN-PREDICT STUDY
Hugo Huisman, Carina Mels, Johannes Van Rooyen, Ruan Kruger, Carla Fourie, Lebo Gafane, Wayne Smith, Alta Schutte
Pages: 68 - 68
Background/Objectives: Tetrahydrobiopterin (BH4) is a cofactor for nitric oxide synthase (NOS). Oxidative stress, reported in black populations (1), may lead to the oxidation of BH4, the uncoupling of eNOS, decreased NO and increased superoxide levels (2,3). We compared BH4 and markers of oxidative stress...
Conference Abstract
9.2 DELETION OF CHROMOSOME 9P21 NONCODING CARDIOVASCULAR RISK INTERVAL IN MICE INDUCES A PROTHROMBOTIC PHENOTYPE
Amel Mohamadi, Mustapha Bourhim, Gemma Basatemur, Huguette Louis, Athanase Benetos, Patrick Lacolley, Ziad Mallat, Veronique Regnault
Pages: 68 - 68
Background: SNPs on chromosome 9p21.3 risk locus have been associated with cardiovascular diseases. We have established a direct mechanistic link between 9p21 noncoding risk interval and susceptibility to aneurysm in a mouse model with a targeted deletion of the 9p21 noncoding cardiovascular disease...
Conference Abstract
P.069 OSTEOPOROSIS IS ASSOCIATED WITH INCREASED AORTIC PULSE WAVE VELOCITY
B. McDonnell, A. So, C. Bolton, M. Munnery, S. Williams, Yasmin, K. Poole, W.D. Evans, C.M. McEniery, I.B. Wilkinson, J.R. Cockcroft
Pages: 68 - 68
Conference Abstract
P54 SEX DIFFERENCES IN AMBULATORY CENTRAL BLOOD PRESSURE AND PULSE WAVE REFLECTIONS IN UNTREATED PATIENTS
Bernhard Hametner, Christopher Clemens Mayer, Katy Whitelegg, Thomas Weber, Peter Fitscha, Siegfried Wassertheurer
Pages: 68 - 69
Objectives: Sex differences for parameters of arterial wave reflection and arterial stiffness were reported from single office measurements, but circadian patterns were not extensively investigated up to now. The aim of this study was to determine sex differences between day and night values of ambulatory...
Conference Abstract
9.3 FUNCTIONAL AORTIC CHANGES INDUCED BY A HIGH SALT DIET
Kathleen Connolly, Mark Butlin, Bart Spronck, Carmel McEniery, Alberto Avolio, Ian Wilkinson
Pages: 68 - 69
Objective: This study examines effects of high salt diet on arterial blood pressure and aortic function in rats.
Methods: Sprague-Dawley rats were fed either high salt content chow or normal chow from weaning. Weight, tail-cuff systolic blood pressure (SBP), water and food intake, and urine output were...
Conference Abstract
P.070 ARTERIAL STIFFNESS ALTERATIONS DURING HEMODIALYSIS
J. Egresits, T. El Hadj Othmane, Á. Tabák, B. Fekete, J. Nemcsik, I. Kiss, A. Tislér
Pages: 68 - 69
Research Article
Gender-differences in prevalence and outcome of ischemic stroke and promoting factors of atrial thrombi
Karsten Keller, Martin Geyer, Thomas Münzel, Mir Abolfazl Ostad
Pages: 68 - 78
Background: Ischemic stroke is an important cause of death and disability. However, data about gender-differences in stroke are controversial.
Methods: In the nationwide sample, male and female inpatients were selected by screening for ischemic stroke by ICD-Code(I63) and compared. In a second study,...
Conference Abstract
P.071 METABOLIC SYNDROME DEFINITIONS AND VASCULAR PHENOTYPE
E.A. Ellins, A.E. Donald, E. Brunner, D. Witte, M. Shipley, S. O’Meagher, J.E. Deanfield, J.P. Halcox
Pages: 69 - 69
Conference Abstract
2.1 KNOCK-OUT OF MATRIX METALLOPROTEINASE-12 EXACERBATES COMPROMISED MECHANICAL HOMEOSTASIS IN ARTERIAL AGING
Bart Spronck, Abhay B. Ramachandra, Jakub Toczek, Jinah Han, Mehran Sadeghi, Jay D. Humphrey
Pages: 69 - 69
Background: Matrix metalloproteinase-12 (MMP12) may modulate arterial stiffening with age [1]. We aimed to study the effect of aging on biaxial arterial stiffness in wild-type (WT) and MMP12 knock-out (MMP12-/-) mice.
Methods and Results: After euthanasia, descending thoracic (DTA) and suprarenal abdominal...
Conference Abstract
P55 TARGET ORGAN DAMAGE AND BLOOD PRESSURE VARIABILITY IN HYPERTENSION
Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Athanasios Angelis, Nikolaos Loakeimidis, Panagiotis Xaplanteris, Christos Georgakopoulos, Evangelia Sigala, Losif Koutagiar, Angeliki Rigatou, Dimitrios Tousoulis
Pages: 69 - 69
Purpose/Background/Objectives: Hypertension is associated with several markers of subclinical target organ damage (TOD). Short-term blood pressure variability (SBPV) is a prognostic factor for cardiovascular events in hypertensives. We hypothesised that there is a relationship between SBPV and TOD in...
Conference Abstract
9.4 EVOLUTION OF CARDIAC FUNCTION AND METABOLISM DURING AGING IN A MURINE ANIMAL MODEL OF OBESITY
Delphine Lambert, Fatiha Maskali, Sylvain Poussier, Alexandra Clement, Jean-Loup Machu, Pierre-Yves Marie, Patrick Lacolley, Athanase Benetos, Laure Joly
Pages: 69 - 69
Purpose/Background/Objectives: Obesity is a well-known risk factor of cardiovascular diseases and a potentially modifiable determinant of arterial ageing. The objectives of this experimental study were to assess the effects of a long-term high fat diet (HFD) on metabolism, adipose tissues and phenotypes...
Conference Abstract
P.072 PARENTAL SMOKING AND VASCULAR DAMAGE IN YOUNG ADULT OFFSPRING: IS EARLY LIFE EXPOSURE CRITICAL? THE ATHEROSCLEROSIS RISK IN YOUNG ADULTS STUDY
C.C. Geerts, D.E. Grobbee, M.L. Bots, C.S.P. Uiterwaal
Pages: 69 - 69
Conference Abstract
2.2 GREATER BLOOD PRESSURE VARIABILITY IS ASSOCIATED WITH LOWER COGNITIVE PERFORMANCE – THE MAASTRICHT STUDY
Tan Lai Zhou, Abraham Kroon, Coen Stehouwer, Martin van Boxtel, Frans Verhey, Miranda Schram, Thomas van Sloten, Ronald Henry
Pages: 69 - 70
An increasing number of individuals will face age-related cognitive difficulties, as life expectancy has increased globally. It is therefore important to identify modifiable risk factors for cognitive impairment. Very short- to mid-term blood pressure variability (BPV) may be such factor, as it may cause...
Conference Abstract
P56 ASSOCIATION BETWEEN URIC ACID AND CARDIAC, VASCULAR AND RENAL TARGET ORGAN DAMAGE IN HYPERTENSIVES SUBJECTS
Alessandro Maloberti, Marisa Varrenti, Nicola Triglione, Lucia Occhi, Francesco Panzeri, Marta Alloni, Luca Giupponi, Paola Vallerio, Matteo Casati, Guido Grassi, Giuseppe Mancia, Cristina Giannattasio
Pages: 69 - 69
Background: To date no definitive results exist about the relationship of Serum Uric Acid (SUA) and TOD in HT subjects. We sought to determine if such an association exist between SUA and subclinical cardiac, vascular and renal alterations in HT.
Methods: We enrolled 632 consecutive outpatients, followed...
Conference Abstract
9.5 COAGULATION CONTROL BY THE RHOA PATHWAY AND THE EXCHANGE FACTOR ARHGEF1
Camille Rouillon, Amel Mohammadi, Gervaise Loirand, Veronique Regnault, Patrick Lacolley
Pages: 69 - 69
Platelet activation by thrombin is an auto-amplification loop of thrombin generation, a major factor in the formation of atherosclerotic plaques. The small G protein RhoA, under the direct control of the exchange factor Arhgef1, modulates several cellular functions in inflammation. The objective was...
Conference Abstract
P.073 LONGITUDINAL DEVELOPMENT OF WAIST AND HIP CIRCUMFERENCES: INDEPENDENT AND OPPOSITE ASSOCIATIONS WITH PRE-CLINICAL ATHEROSCLEROSIS. THE AMSTERDAM GROWTH AND HEALTH LONGITUDINAL STUDY
I. Ferreira, J.W. Twisk, C.D. Stehouwer
Pages: 69 - 69
Conference Abstract
P57 ASSESSMENT OF PULSE WAVE VELOCITY AND ASSOCIATION TO TARGET ORGAN DAMAGE IN TREATMENT-NAïVE HYPERTENSIVE PATIENTS: A COMPARISON OF SPHYGMOCOR AND MOBIL-O-GRAPH
Enrique Rodilla, Jose Antonio Costa, Francisco Perez, Carmen Gonzalez, Jose Maria Pascual
Pages: 69 - 70
Introduction: Comparison of Mobil-O-Graph® with SphygmoCor® exclusively in treatment- naïve hypertensives has never been done. Aims of the study were to assess 1) intra- device agreement between both methods, 2) inter-device agreement between two surface measurements of SC (subtracted distance (cfPWVsub))...
Conference Abstract
9.6 VENTRICULAR VOLUME AND ARTERIAL FLOW DURING PRELOAD REDUCTION: AN MRI STUDY
Sandra Neumann, Gergely Szantho, Emma C. Hart, Nathan E. Manghat, Mark S. Turner, Mark C.K. Hamilton
Pages: 69 - 69
Lower body negative pressure (LBNP) has been used to assess the cardiovascular effect of preload reduction. We are the first to use MRI to investigate ventricular volumes and great vessel flow during LBNP.
13 volunteers (23–47 years) underwent LBNP at 0, −5 and −20mmHg. We acquired contiguous short...
Conference Abstract
P.074 EFFECT OF SMOKING ON ARTERIAL STIFFNESS IN PATIENTS WITH WHITE COAT HYPERTENSION
S.-M. Kyvelou, C. Vlachopoulos, G. Vyssoulis, P. Pietri, P. Spanos, K. Baou, P. Xaplanteris, C. Stefanadis
Pages: 69 - 70
Review Article
Fetal programming and vascular dysfunction
T.A. Meister, E. Rexhaj, S.F. Rimoldi, U. Scherrer, C. Sartori
Pages: 69 - 77
Cardiovascular diseases are the main cause of mortality and morbidity in Western countries, but the underlying mechanisms are still poorly understood. Genetic polymorphisms, once thought to represent a major determinant of cardiovascular risk, individually and collectively, only explain a tiny fraction...
Short Communication
Effect of aldosterone antagonists on common carotid artery’s intima-media thickness, stiffness indices and flow mediated vasodilatation of brachial artery in CAD patients
Vohra Kanchan, Krishan Pawan, Varma Sudhir, Kalra Harpreet Singh
Pages: 69 - 72
Research Article
Radial Pulse Wave Analysis in Young Male Elite Athletes
Fernando Clara, José Alfie, Gustavo Blanco, Cecilia Resina, Meschino Gustavo, Mariana Fita
Pages: 69 - 74
Background: Indicators obtained from the analysis of the radial pulse wave allow an indirect evaluation of the interaction between cardiac ejection and arterial walls.
Objectives: To analyze the characteristics of the arterial pulse in young elite athletes through a cross-sectional observational study.
Methods:...
Conference Abstract
P.075 TISSUE CHARACTERIZATION OF CAROTID WALL IN MILDLY DISEASED ARTERIES: COMPARISON OF VIDEODENSITOMETRIC ANALYSIS AND INTEGRATED BACKSCATTER
M. Failla, C. Morizzo, M. Kozàkovà, M. Paterni, S. Maestroni, E. Fantini, C. Giannattasio, C. Palombo, G. Mancia
Pages: 70 - 70
Conference Abstract
2.3 OCCUPATIONAL, SPORT AND LEISURE RELATED PHYSICAL ACTIVITY HAVE CONTRASTING EFFECTS ON NEURAL BAROREFLEX SENSITIVITY. THE PARIS PROSPECTIVE STUDY III
Rachel Climie, Pierre Boutouyrie, Marie-Cecile Perier, Edouard Chaussade, Matthieu Plichart, Lucile Offredo, Catherine Guilbout, Thomas van Sloten, Frederique Thomas, Bruno Pannier, James Sharman, Stephane Laurent, Xavier Jouven, Jean-Philippe Empana
Pages: 70 - 70
Background: Physical activity (PA) is beneficial for baroreflex sensitivity (BRS), but it is unclear whether the type of PA has similar effects on the neural (nBRS) or vascular (carotid stiffness) components of BRS. We sought to determine this in healthy adults from a community- based study via assessment...
Conference Abstract
P58 ARTERIAL STIFFNESS IS ASSOCIATED WITH LOWER PERFORMANCE ON THE COGNITIVE TESTS AT DIFFERENT DOMAINS IN HYPERTENSIVE PATIENTS
Henrique Muela, Valeria Costa-Hong, Michel Machado, Natalia Moraes, Claudia Memória, Monica Yassuda, Edson Shu, Ayrton Massaro, Ricardo Nitrini, Alfredo Mansur, Luiz Bortolotto
Pages: 70 - 70
Background: Cognitive impairment and elevated arterial stiffness are described in arterial hypertension (AH), but its correlations are not well studied.
Objectives: To study the cognitive function at different domains and arterial properties in patients with AH stage 1 to 3 compared to normotensives...
Conference Abstract
9.7 THORACIC AORTA PWV ASSESSMENT BY USING 4D FLOW IN MRI
Gilles Soulat, Umit Gencer, Nadjia Kachenoura, Konstantinos Stampoulis, Yousef Alattar, Emmanuel Messas, Olivier Villemain, Stéphane Laurent, Elie Mousseaux
Pages: 70 - 70
Purpose: In MRI, thoracic aorta pulse wave velocity (TAPWV) is usually estimated by 2D phase contrast (PC) with either in plane or through plane velocity acquisition. Thanks to technological improvement, 4D PC with full coverage of the TA and 3 dimension velocity encoding thought time can be now achievable...
Conference Abstract
P.076 EFFECTS OF REGULAR TRAINING ON PERIPHERAL ARTERIAL COMPLIANCE IN YOUNG HEALTHY MALES
N. Potocnik, K. Cankar, Z. Melik, V. Starc
Pages: 70 - 70
Conference Abstract
2.4 CENTRAL SYSTOLIC BLOOD PRESSURE PROVIDES ADDITIONAL INFORMATION IN RISK PREDICTION IN HEMODIALYSIS PATIENTS
Christopher C. Mayer, Julia Matschkal, Pantelis A. Sarafidis, Stefan Hagmair, Georg Lorenz, Susanne Angermann, Matthias C. Braunisch, Marcus Baumann, Uwe Heemann, Christoph Schmaderer, Siegfried Wassertheurer
Pages: 70 - 70
Background: Association of Ambulatory Blood Pressure Monitoring (ABPM) with mortality depends on cardiac function in hemodialysis patients. Evidence for the predictive power of central Systolic Pressure (cSBP) is inconclusive. Thus, this study aimed to investigate the additional information of ambulatory...
Conference Abstract
P59 ARTERIAL STIFFNESS AND PERIPHERAL VASCULAR RESISTANCE IN OFFSPRING OF HYPERTENSIVE PARENTS – INFLUENCE OF GENDER AND OTHER CONFOUNDERS
Niels Henrik Buus, Rasmus Carlsen, Dinah Khatir, Hans Eiskjær, Michael John Mulvany, Karin Skov
Pages: 70 - 70
Aim: Established essential hypertension (EH) is associated with increased arterial stiffness and peripheral resistance, but the extent of vascular changes in persons genetically predisposed for EH is uncertain.
Methods: Participants from the Danish Hypertension Prevention Project (DHyPP) (having two...
Conference Abstract
9.8 NEAR INFRARED SPECTROSCOPY (NIRS) CAN DETECT IMPROVEMENTS IN ARTERIAL FUNCTION FOLLOWING 6-MONTHS OF MARATHON TRAINING
Siana Jones, Andrew D’Silva, Alun Hughes
Pages: 70 - 70
Background: Endurance training improves vascular function and skeletal muscle perfusion. NIRS can measure changes in oxygenated haemoglobin (oxy-Hb) in the skeletal muscle microvascular bed. Therefore, combined with arterial occlusion, NIRS has the potential to assess microvascular function within skeletal...
Conference Abstract
P.077 IN VIVO VALIDATION OF A NON-INVASIVELY MEASURED LOCAL PULSE WAVE VELOCITY: IMPROVED PERFORMANCE USING AORTIC VALVE CLOSURE IN STEAD OF AORTIC VALVE OPENING
E. Hermeling, K.D. Reesink, A.P. Hoeks
Pages: 70 - 70
Conference Abstract
2.5 DOES WAVE REFLECTION PROTECT THE MICROVASCULATURE FROM HIGH PULSE PRESSURE?
Avinash Kondiboyina, Joe Smolich, Michael Cheung, Berend Westerhof, Nico Westerhof, Jonathan Mynard
Pages: 70 - 71
Background: Wave reflection (caused by a stiffness increase from large to small arteries) has been considered to protect against high microvasculature Pulse Pressures (mPP) (1). However, according to transmission line theory, Transmission (T) and Reflection (R) coefficients are proportional (T = 1+R),...
Conference Abstract
P60 PSYCHOLOGICAL DETERMINANTS OF TARGET ORGAN DAMAGE IN HYPERTENSIVE PATIENTS: FOCUS ON PULSE WAVE VELOCITY AND DEPRESSION
Andrea Greco, Alessandro Maloberti, Marisa Varrenti, Ilaria Bassi, Enrico Piccinelli, Francesco Panzera, Stephan Laurent, Pierre Boutouyrie, Massimo D’Addario, Anna Maria Annoni, Patrizia Steca, Cristina Giannattasio
Pages: 70 - 71
Objective: Prior studies have suggested that the principal determinants of arterial stiffening are age, BP and others CV risk factors such as dyslipidemia and diabetes. However, scanty data are available on the role of psychological factors on arterial stiffness. The aim of the current cross-sectional...
Conference Abstract
9.9 FLOW-MEDIATED SLOWING AS A NOVEL METHOD FOR THE NON-INVASIVE ASSESSMENT OF ENDOTHELIAL FUNCTION
Amedra Basgaran, Kaisa Maki-Petaja, Ian Wilkinson, Carmel McEniery
Pages: 70 - 70
Background: Flow-mediated slowing (FMS) assesses the slowing of pulse wave velocity (PWV) in response to reactive hyperaemia, to provide a measure of endothelial function. We assessed the reproducibility of FMS and whether the technique is sensitive to the influence of age. FMS was compared to the commonly...
Conference Abstract
P.078 VALIDATION OF A NEW AUTOMATED REAL-TIME MEASURING SYSTEM FOR CAROTID INTIMA–MEDIA THICKNESS ASSESSMENT
F. Faita, C. Giannarelli, V. Gemignani, E. Bianchini, M. Demi, L. Ghiadoni
Pages: 70 - 71
Conference Abstract
9.10 STRUCTURAL AND FUNCTIONAL ARTERIAL ABNORMALITIES IN FIBROMUSCULAR DYSPLASIA ARE IN THE CONTINUUM OF HYPERTENSION: AN IMAGING AND BIOMECHANICAL STUDY
Louise Marais, Pierre Boutouyrie, Hakim Khettab, Chantal Boulanger, Aurelien Lorthioir, Mickael Franck, Ralph Niarra, Jean-Marie Renard, Yann Chambon, Xavier Jeunemaitre, Mustapha Zidi, Pierre-François Plouin, Stéphane Laurent, Michel Azizi
Pages: 70 - 71
Fibromuscular dysplasia (FMD) is a non-atherosclerotic non-inflammatory arterial disease of unknown origin. We previously showed the presence of triple signal (TS) at ultrasound within common carotid artery (CCA) wall. We aimed at coupling TS presence with microconstituents of the vessel wall.
We included...
Conference Abstract
P.079 EFFECTS OF LOW-GRADE INFLAMMATION ON ARTERIAL STIFFNESS AND WAVE REFLECTIONS IN HYPERTENSIVE PATIENTS WITH METABOLIC SYNDROME
P. Pietri, C. Vlachopoulos, K. Aznaouridis, G. Vyssoulis, A. Tsokanis, A. Baou, C. Stefanadis
Pages: 71 - 71
Conference Abstract
2.6 FEASIBILITY OF AORTIC WAVE INTENSITY ANALYSIS FROM SEQUENTIALLY ACQUIRED CARDIAC MRI AND NON-INVASIVE CENTRAL BLOOD PRESSURE
Anish Bhuva, Niro Nadarajan, Andrew D’Silva, Camilla Torlasco, Redha Boubertakh, Siana Jones, Paul Scully, Rachel Bastiaenen, Guy Lloyd, Sanjay Sharma, James Moon, Kim Parker, Charlotte Manisty, Alun Hughes
Pages: 71 - 71
Background: Wave intensity analysis (WIA) in the aorta offers important clinical and mechanistic insights but is difficult non-invasively. We performed WIA by combining high temporal resolution cardiovascular magnetic resonance (CMR) flow velocity and non-invasive central blood pressure (BP) waveform...