N. Hadjiloizou, J. Davies, D. Francis, A.J. Baksi, K. Parker, A. Hughes, J. Mayet
Pages: 48 - 48
J.S. Seidlerova, J.A.S. Staessen, M.B. Bochud, M.C. Cwynar, M.D. Dolejsova, T.K. Kuznetsova, T.N. Nawrot, A.O. Olszanecka, K.S. Stolarz, L.T. Thijs, W.W. Wojciechowska, HAS.-B. Struijker-Boudier, KK.-J. Kawecka-Jaszcz, R.C.E. Elston, R.F. Fagard, J.F. Filipovsky
Pages: 48 - 49
Larissa Ribeiro Bessa, Luís Antônio Bahiana Cruz, Rodrigo Lins Sant’Ana de Lima, Maria Cristina Lima Fontenele Presta, Antonio de Assis Oliveira Alves Filho, Roberta de Castro Araújo Cunha, Alana dos Reis Silva, Juan Jailson Oliveira Almeida Costa, Cecília Freitas da Silva Araújo, Diorlene Oliveira da Silva, Lucélia Batista Neves Cunha Magalhães
Pages: 48 - 55
Background: Cardiovascular diseases are the main cause of death worldwide. In this setting, Neck Circumference (NC) and Pulse Wave Velocity (PWV) are simple and valuable tools for an early evaluation of cardiovascular risk through the assessment of upper body obesity and arterial stiffness. However,...
Charlotte E. Mills, Virginia Govoni, Maria Linda Casagrande, Luca Faconti, Andrew J. Webb, J. Kennedy Cruickshank
Pages: 48 - 53
Background: Arterial stiffness (AS), as pulse wave velocity (PWV), is a powerful independent predictor of cardiovascular events and commonly complicates type 2 diabetes (T2D). This trial aims to test if AS, measured by the VaSera machine as cardio-ankle vascular index (CAVI) and by Arteriograph measuring...
Daisuke Maebuchi, Munehisa Sakamoto, Jun Fuse, Hiroaki Tanaka, Yasuyuki Shiraishi, Makoto Takei, Yumiko Inui, Yuumi Sutoh, Yukinori Ikegami, Yukihiko Momiyama
Pages: 48 - 53
Objective: Chronic kidney disease (CKD) is known to be associated with the incidence and mortality of cardiovascular disease. Therefore, the prevention of CKD may improve the mortality of cardiovascular disease. The risk factors of CKD are variable and multifactorial, similar to atherosclerosis. We hypothesized...
Christopher Martens, Blair Denman, Melissa Mazzo, Michael Armstrong, Nichole Reisdorph, Matthew McQueen, Michel Chonchol, Douglas Seals
Pages: 49 - 49
Purpose: Regular calorie restriction (CR) improves endothelial function and lowers aortic stiffness in older mice and humans; however, adherence to sustained CR remains poor, and possibly unsafe in normal weight older adults. Nicotinamide adenine dinucleotide (NAD+) is an important signaling molecule...
Carmel McEniery, Yoav Ben-Shlomo, Margaret May, Melissa Spears, Lyndia Brumback, James Cameron, Chen-Huan Chen, Julio Chirinos, Danuta Czarnecka, Anthony Dart, Richard Devereux, Neeraj Dhaun, Daniel Duprez, Shih-Jen Hwang, David Jacobs, Piotr Jankowski, Julie Janner, Peter Lacy, Gary Mitchell, Riccardo Pini
Pages: 49 - 49
Systolic blood pressure (SBP) differs between the brachial artery and aorta. Prospective data suggest that central pressure predicts future cardiovascular events, but it is unclear if it is superior to brachial pressure.
Methods and Results: A systematic review and individual participant data meta-analysis...
J. Nemcsik, B.C.S. Fekete, G. Speer, G. Bakonyi, J. Egresits, E. Fodor, T.E.H. Othmane, A. Szabo, I. Kiss, A. Tisler
Pages: 49 - 49
Victoria Garcia, Santiago Curcio, Agustina Zinoveev, Gustavo Giachetto, Pedro Chiesa, Daniel Bia, Yanina Zócalo
Pages: 49 - 50
Background: Several works analyze arterial parameters’ (stiffness levels, wall thickness, etc.) association with variations of body mass index (BMI) in pediatric populations.
However, none integrate different arterial parameters as comparable continuous (standardized) variables, in order to assess their...
Giacomo Pucci, Francesca Battista, Leandro Sanesi, Sara Alessio, Giuseppe Schillaci
Pages: 49 - 49
Background: Heart rate (HR) is directly associated to central-to-peripheral pulse wave amplification. We aimed at evaluating the associations between heart rate and each BP component in a cohort of healthy adolescents.
Objective: 470 healthy adolescents (17±1.4 years, 56% boys, brachial BP 123/67±11/7...
D. Adamopoulos, J.F. Argacha, M. Gujic, N. Amai, D. Fontaine, G. Berkenboom, P. van de Borne
Pages: 49 - 49
Marina Di Pilla, Rosa Maria Bruno, Simona Buralli, Melania Sgro’, Piero Amedeo Modesti, Stefano Taddei, Lorenzo Ghiadoni
Pages: 49 - 50
Background: Age and blood pressure (BP) are known to be the main determinants of large artery stiffness. However other factors may lead to an inappropriately high pulse wave velocity (PWV). We investigated the determinants of inappropriately high PWV in hypertensive patients and their possible role in...
C.M. McEniery, Y. Yasmin, M. Munnery, S.M.L. Wallace, B. McDonnell, K.M. Maki-Petaja, S. Hickson, J.R. Cockcroft, I.B. Wilkinson
Pages: 49 - 50
Dóra Batta, Ádám Tabák, Beáta Kőrösi, Orsolya Cseprekál, József Egresits, András Tislér, János Nemcsik
Pages: 49 - 55
Background: Our aim was to study the predictive power of integrated central blood pressure-aortic stiffness (ICPS) risk categories on cardiovascular (CV) mortality in end-stage renal disease (ESRD) patients.
Methods: This is a secondary analysis of a prospective study of 91 ESRD patients on hemodialysis...
Jae Chul Lee, Soo Young Choe, Chan Yeong Heo, Sun Ju Jeong
Pages: 49 - 56
Pulmonary artery hypertension (PAH) is a progressive chronic disease with a high mortality rate. Increased pulmonary vascular resistance and over-proliferation of pulmonary artery endothelial cells lead to remodeling of pulmonary vasculature. Several anti-PAH therapies targeting various pathways involved...
Brooke M. Shafer, Sushant M. Ranadive, Tracy Baynard, Robert W. Motl, Bo Fernhall
Pages: 49 - 55
Background: Multiple sclerosis (MS) is associated with increased risk of cardiovascular disease (CVD) and approximately 25–54% of patients report poor sleep quality. There is evidence from the general population of an association between poor sleep and increased CVD risk, but this is poorly understood...
Charalambos Vlachopoulos, Nikolaos Ioakeimidis
Pages: 49 - 54
Arterial hypertension and dyslipidemia often coexist and constitute major risk factors of ischemic heart disease. Aggressive treatment of both comorbidities is of paramount importance to decrease global risk. Low adherence is a determinant of poor risk factor control and increases adverse cardiovascular...
Haroon Kamran, Louis Salciccioli, Carl-Frederic Bastien, Abhishek Sharma, Jason M. Lazar
Pages: 49 - 54
Background: Chronic Aortic Regurgitation (AR) increases left ventricular preload and afterload, which may enhance arterial wave reflection. The effects of AR on noninvasive measures of arterial wave reflection and central aortic pressure are unknown.
Methods: To determine the relation between AR and...
Veli Yazisiz, Ali Berkant Avci, Ender Terzioğlu
Pages: 49 - 50
Arterial calcification most often occurs in patients with end-stage renal disease who undergo hemodialysis or hyperparathyroidism and it is independently associated with cardiovascular events and death. Calciphylaxis is uncommon in patients with rheumatoid arthritis. We present here development of arterial...
Edward D. Frohlich
Pages: 49 - 49
Fangfei Wei, Anke Raaijmakers, Zhen-Yu Zhang, Theun Pieter van Tienoven, Qi-Fang Huang, Wen-Yi Yang, Lutgarde Thijs, Harry Struijker-Boudier, Peter Verhamme, Karel Allegaert, Jan Staessen
Pages: 50 - 50
Background: The retinal microvasculature can be visualized noninvasively and mirrors the status of the cerebral vasculature. We therefore investigated in 93 prematurely born infants (birth weight < 1000 g) and 87 controls born at term whether neurocognitive performance at ∼11 years is associated with...
Giacomo Pucci, Francesca Battista, Marco D’Abbondanza, Leandro Sanesi, Giuseppe Schillaci
Pages: 50 - 50
Objective: The relationship between sodium consumption, central BP and the main dietary sources of daily sodium intake in adolescence has been poorly explored. We have evaluated sodium intake, central and peripheral BP in a population of Italian adolescents.
Methods: 401 healthy adolescents aged 17±1...
F.U.S. Mattace-Raso, N.M. van Popele, A. Hofman, J.C.M. Witteman
Pages: 50 - 50
Paola Vallerio, Ilenia D’Alessio, Alessandro Maloberti, Marisa Varrenti, Simone Maggioni, Valentina Cantu, Marco Carbonaro, Maria Cristina Ferrara, Elisa Spada, Bruno Palmieri, Alfredo Lista, Cristina Giannattasio
Pages: 50 - 50
Objective: Thoracic Endovascular Aortic Repair (TEVAR) currently represents the gold standard of treatment for Blunt Thoracic Aortic Injury (BTAI). Nevertheless, there is an ongoing debate surrounding its safety and efficacy and its subsequent CV effects. The present study is aimed at assessing heart...
Christian D. Peters, Ole N. Mathiasen, Henrik Vase, Jesper Bech, Kent L. Christensen, Anne P. Schroeder, Ole Lederballe, Hans Rickers, Ulla Kampmann, Per L. Poulsen, Sten Langfeldt, Gratien Andersen, Klavs W. Hansen, Hans E. Bøtker, Morten Engholm, Jannik B. Bertelsen, Jens F. Lassen, Erling B. Pedersen, Anne Kaltoft, Niels H. Buus
Pages: 50 - 50
Background: A recent sham-controlled trial (ReSET) showed no sustained effect of renal denervation (RDN) on 24-hour ambulatory blood pressure (24hA-BP) measurements in patients with treatment resistant hypertension.1 The aim of this substudy was to investigate, whether RDN affects central blood pressure...
J. Bellien, M. Iacob, C. Thuillez, R. Joannides
Pages: 50 - 50
Markus A. Geith, Gerhard Sommer, Thomas Schratzenstaller, Gerhard A. Holzapfel
Pages: 50 - 50
The most challenging complication after coronary stent implantation is in-stent restenosis [1], which is mainly caused by mechanically induced injuries due to overloading. From a biomechanical point of view, the processes occurring inside the arterial tissues during stent implantation (SI) is rather...
Benjamin Bonnet, Frank Jourdan, Guilhem du Cailar, Pierre Fesler
Pages: 50 - 50
Objective: Non invasive methods have been proposed to assess end systolic left ventricular (LV) elastance (Ees), but clinical application remains complex. The aim of the present study was to 1) estimate Ees according to modeling of LV pressure-volume (P-V) curve during ejection and validate our method...
K. Baou, C. Vlachopoulos, E. Manesis, N. Ioakeimidis, G. Papatheodoridis, J. Koskinas, A. Archimandritis, C. Stefanadis
Pages: 50 - 50
Stéphane Laurent
Pages: 50 - 50
Manuel Vázquez Blanco, Hilda Ruda Vega, Roberto A. Guerri-Guttenberg, Rodolfo Giuliano, Daniel R. Grana, Francisco Azzato, José Milei
Pages: 50 - 57
Objective: A systematic histological, morphometric and immunohistochemical (PAI-1 and TGF-β1) study of umbilical vessels in normal and pathological conditions was undertaken in order to describe and compare the lesions found.
Methods: Segments of umbilical cords were obtained from 92 pregnancies/107...
Xiaoqing Peng, Martin Schultz, Michael Cheung, Melissa Wake, Jonathan Mynard, David Burgner, Richard Liu, James Sharman
Pages: 51 - 51
Objective: Reservoir-excess pressure measured using tonometry methods predicts cardiovascular events, but the operator-dependency of tonometry is an impediment to widespread use. A cuff-based blood pressure device has been developed to derive reservoir-excess pressure from measured brachial pressure...
Charlotte Mills, Luca Faconti, Virginia Govoni, Steve Morant, Maria-Linda Casagrande, Haotian Gu, Benyu Jiang, Andrew Webb, Kennedy Cruickshank
Pages: 51 - 51
Purpose/ background/ objectives: People with or at risk of Type II diabetes (T2DM) are at increased risk of vascular disease and arterial stiffness (AS). We hypothesized that spironolactone and dietary nitrate (beetroot juice) separately and together would reduce AS, measured as cardiac-ankle vascular...
R. Sabit, C.E. Bolton, J.M. Edwards, A.G. Fraser, D.J. Shale, J.R. Cockcroft
Pages: 51 - 51
Sandra Neumann, Mark Hamilton, Julian Paton, Angus Nightingale, Jonathan Brooks, Emma Hart, Giovanni Biglino
Pages: 51 - 51
Introduction: Hypertension is associated with stiffening of blood vessels, reduced arterial lumen and reduced cerebral blood flow; however, it is not known how lower cerebral blood flow relates to arterial structure or impacts on wave dynamics. We hypothesise increased backward wave energy and faster...
Martin Schultz, Dean Picone, Xiaoqing Peng, Andrew Black, Nathan Dwyer, Phillip Roberts-Thomson, James Sharman
Pages: 51 - 51
Background: Mean arterial pressure (MAP) and diastolic blood pressure (DBP) are thought to consistently decline approximately 1–3 mmHg from the aorta to peripheral large arteries, thus providing a small pressure gradient to aid blood flow. The magnitude of this gradient is important for correct waveform...
M. Briet, P. Houillier, M. Froissart, E. Bozec, C. Gaucci, C. Collin, S. Laurent, P. Boutouyrie
Pages: 51 - 51
Matthew K. Armstrong, Martin G. Schultz, Dean S. Picone, James E. Sharman
Pages: 51 - 52
Introduction: Aortic stiffness predicts cardiovascular mortality but is limited as a risk marker because it is dependent on blood pressure (BP). A potential solution is provided from the ratio of aortic-to-brachial artery stiffness (ab-ratio), which is purported to be a BP-independent risk marker among...
Dean Picone, Martin Schultz, Xiaoqing Peng, Andrew Black, Nathan Dwyer, Phil Roberts-Thomson, Velandai Srikanth, James Sharman
Pages: 51 - 51
Background: Accuracy of brachial cuff blood pressure (BP) may be influenced by individual variability in central-to-peripheral systolic BP (SBP)-amplification, but this has never been determined. We aimed to achieve this by characterising SBP-amplification phenotypes and examining associations with cuff...
J.G. Kips, E.R. Rietzschel, M.L. De Buyzere, T.C. Gillebert, L.M. Van Bortel, P. Segers
Pages: 51 - 51
Junjing Su, Charlotte Manisty, Kim H. Parker, Soren Mellemkjaer, Luke Howard, Ulf Simonsen, Alun Hughes
Pages: 51 - 52
Background: The objective of the study was to apply wave intensity analysis (WIA) in the pulmonary artery to characterise the magnitude, origin, type and timing of arterial waves in individuals with and without pulmonary hypertension (PH).
Methods: Right heart catheterisation was performed using a pressure...
A. Paini, M.L. Muiesan, M. Salvetti, C. Corbellini, E. Belotti, G. Galbassini, C. Agabiti-Rosei, C. Aggiusti, L. Micheletti, V. Paderno, E. Agabiti-Rosei
Pages: 51 - 51
A. Mahmud, M. McNulty, E. McGovern, V. Young, M. Tolan, J. Feely
Pages: 51 - 52
Alun D. Hughes, Kim H. Parker, Justin E. Davies
Pages: 51 - 59
The intermittent ejection of blood by the ventricle results in pulsatile pressure and flow waveforms in the circulation. Understanding and characterizing this pulsatile behaviour is attracting increasing clinical interest, as it may have important implications for risk prediction and the mechanisms of...
Alireza Karimi, Mahdi Navidbakhsh, Mansour Alizadeh, Ahmad Shojaei
Pages: 51 - 56
Purpose: Coronary Artery Disease (CAD) is the main cause of mortalities worldwide. The Saphenous Vein (SV) and Umbilical Vein (UV) are the most common veins using for treatment as a Coronary Artery Bypass Graft (CABG). The mechanical properties of UV owing to its long-term patency for CABG are deemed...
H. Struijker-Boudier
Pages: 51 - 51
Alun D. Hughes, Nish Chaturvedi
Pages: 51 - 51
Vienna Brunt, Rachel Gioscia-Ryan, Zachary Sapinsley, Melanie Zigler, James Richey, Douglas Seals
Pages: 52 - 52
The gut microbiome, an emerging mediator of host physiological function, is adversely altered by aging and many diseases, termed “gut dysbiosis.” One consequence of gut dysbiosis is elevated circulating levels of the gut-derived metabolite trimethylamine N-oxide (TMAO), which has been directly linked...
Nicole Di Lascio, Claudia Kusmic, Francesco Stea, Francesca Lenzarini, Francesco Faita
Pages: 52 - 52
Wave Intensity Analysis (WIA) can provide information about the interaction between vascular and cardiac system. WIA-derived indexes have quantitative physiological meaning. We investigated age-associated changes in WIA-derived parameters in mice and correlated them with biomarkers of cardiac function.
Sixteen...
I. Ferreira, J.W. Twisk, C.D. Stehouwer
Pages: 52 - 52
Andrea Guala, F. Tosello, D. Leone, L. Sabia, F. D’Ascenzo, T. Crea, C. Moretti, F. Gaita, F. Veglio, L. Ridolfi, A. Milan
Pages: 52 - 52
Purpose: Aortic blood pressure has a superior prognostic value with respect to the brachial pressure [
1]. Nonetheless, the low efficacy of the most used non-invasive methods (i.e., approaches based on the generalized transfer function (GTF)) may hamper the detection of this superiority in population...
Rachel Climie, Dean Picone, James Sharman
Pages: 52 - 52
Objectives: Aortic reservoir function independently predicts end organ damage in cross sectional analyses. However, longitudinal associations are more important regarding causation, but this has never been examined and was the goal of this study.
Methods: Aortic reservoir function (excess pressure integral...
E. Hermeling, K.D. Reesink, A.P. Hoeks
Pages: 52 - 52
János Nemcsik, Orsolya Cseprekál, Ádám Tabák, Dóra Batta, József Egresits, István Kiss, András Tislér
Pages: 52 - 53
Background: The evaluation of arterial stiffness and central haemodynamics represent a new tool of cardiovascular (CV) risk stratification. Our aim was to create an integrated central pressure-stiffness risk score (ICPS score) which incorporate the predictive potential of identical parameters.
Methods:...
Kim Phan, Yessica Haydee Gomez, Jessica Gorgui, Amira El-Messidi, Robert Gagnon, Stella Daskalopoulou
Pages: 52 - 52
Objective: To develop a model for the 1st trimester prediction of pre-eclampsia.
Methods: In this prospective longitudinal study, women with high-risk singleton pregnancies were recruited and arterial stiffness was measured using applanation tonometry (SphygmoCor, AtCor) and compared between women who...
M. Banerjee, C. Austin, R.A. Malik, J.K. Cruickshank
Pages: 52 - 52
Luca Faconti
Pages: 52 - 53
Objective: Traditional cardiovascular (CV) risk factors do not fully explain ethnic differences in CV disease [1,2]. We tested if pulse wave velocity (PWV) and Augmentation Index (AIx) and their determinants from childhood may underlie ethnic variability in CV risk as young adults in the ‘DASH’ longitudinal...
Jacqueline A. Augustine, Wesley K. Lefferts, Kevin S. Heffernan
Pages: 52 - 55
Bernard I. Lévy
Pages: 52 - 52
Youngju Choi, Seiji Maeda, Takeshi Otsuki, Asako Miyaki, Nobutake Shimojo, Mutsuko Yoshizawa, Hitoshi Shiraki, Ryuichi Ajisaka
Pages: 52 - 58
Background: Endurance exercise training decreases arterial stiffness, whereas high-intensity strength exercise training increases arterial stiffness. However, the mechanisms underlying the adaptations to the 2 types of exercise training remain unclear. Increased oxidative stress induces vasoconstriction...
Andrea Guala, Jose Rodriguez-Palomares, Lydia Dux-Santoy, Gisela Teixido-Tura, Giuliana Maldonado, Nicolas Villalva, Filipa Valente, Laura Galian, Marina Huguet, Laura Gutierrez, Teresa Gonzalez, Ruben Fernandez, Augusto Sao-Aviles, David Garcia-Dorado, Artur Evangelista
Pages: 53 - 53
Purpose: Bicuspid aortic valve (BAV) is a cardiac congenital disease associated with ascending aorta (AAo) dilation. The study of the impact of aortic biomechanics in this population has been limited by technical difficulties. Contrasting results have been reported for distensibility while studies including...
Chloe Park, Nish Chaturvedi, Alun Hughes
Pages: 53 - 53
Background: High blood pressure (BP) is a major risk factor for elevated LV mass (LVM) in adults. Evidence suggests that BP tracks from childhood into adolescence and adulthood, however findings on the association between childhood BP and LVM are inconsistent and the temporal relationship between BP...
D. Adamopoulos, J.F. Argacha, M. Gujic, C. Garcia, N. Preumont, J.P. Degaute, S. Goldman, P. van de Borne
Pages: 53 - 53
Froso Sophocleous, Benedetta Biffi, Elena Giulia Milano, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli, Chiara Bucciarelli-Ducci, Tom Gaunt, Silvia Schievano, Giovanni Biglino
Pages: 53 - 54
Background: Bicuspid aortic valve (BAV) is a congenital heart disease associated with aortic wall abnormalities and co-existing with other congenital defects (e.g. aortic coarctation). This study aimed to explore aortic shape features in a BAV population, identifying sub-groups with different aortic...
Georgios Georgiopoulos, Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Athanasios Gravos, Panagiota Pietri, Christos Georgakopoulos, Kimon Stamatelopoulos, Dimitrios Tousoulis
Pages: 53 - 54
Purpose/Background/Objectives: Patients with rheumatoid arthritis (RA) have a higher arterial stiffness than their age-matched healthy counterparts and an increased inflammatory burden that might be associated with their increased cardiovascular risk. Tumor necrosis factor alpha (TNF)-antagonists have...
Y. Plantinga, L. Ghiadoni, A. Magagna, S. Salvini, M. Ceroti, G. Masala, D. Palli, S. Taddei, A. Salvetti
Pages: 53 - 53
A.E. Schutte, H.W. Huisman, M. Reimann, J.M. Van Rooyen, L. Malan, N.T. Malan
Pages: 53 - 53
H.W. Huisman, A.E. Schutte, J.M. Van Rooyen, M. Reimann, L. Malan, N.T. Malan, R. Schutte
Pages: 53 - 54
Keisei Kosaki, Jun Sugawara, Asako Zempo-Miyaki, Seiji Maeda
Pages: 53 - 57
Background: The determinants responsible for increasing central pressure augmentation, a strong risk factor for cardiovascular disease, remain highly controversial. The aim of this study was to determine the contribution of the impedance mismatch between central and leg arteries on central pressure augmentation....
Jan Filipovský
Pages: 53 - 53
Michael Ebner, Kim Parker, Tom Vercauteren, Sébastien Ourselin, Siegfried Wassertheurer, Alun Hughes, Bernhard Hametner
Pages: 54 - 54
Background: At present, reservoir pressure parameters are derived from arterial pressure waveforms regardless of the location of measurement. However, a comparison between sites has not been made, and site-related differences may affect interpretation. In this study, we computed reservoir pressure waveform...
Olga Tereshina, Alexcey Vachev
Pages: 54 - 54
Background: The benefit of carotid revascularization is decreased by the occurrence of restenosis at the site of surgery, which is associated with a modestly increased risk of stroke. Preventing restenosis plays pivotal role in the overall treatment and prevention of stroke in patients with carotid artery...
J. Rosa, R. Holaj, B. Strauch, O. Petrak, T. Pikus, T. Zelinka, D. Wichterle, j. Widimsky
Pages: 54 - 54
Bart Spronck, Isabella Tan, Koen Reesink, Dana Georgevsky, Tammo Delhaas, Alberto Avolio, Mark Butlin
Pages: 54 - 54
Background: Pulse wave velocity (PWV) is quantified by time difference of arrival of the blood pressure (BP) wave at two sites along the arterial bed (transit time; TT-PWV), or by combining measured arterial pressure and diameter using the Bramwell-Hill equation (BH-PWV). Besides the dependence of PWV...
Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Nikolaos Ioakeimidis, Mahmud Abdelrasoul, Christos Georgakopoulos, Panagiota Pietri, Christodoulos Stefanadis, Dimitrios Tousoulis
Pages: 54 - 54
Purpose/Background/Objectives: Smoking increases aortic stiffness which is an important predictor of cardiovascular risk. Electronic cigarettes (EC) simulate tobacco cigarette (TC) and have been advocated as a less harmful alternative. We investigated the acute effect of EC smoking on aortic stiffness...
J. Spac, J. Hanus, M. Soucek, H. Nemcova
Pages: 54 - 54
Jorge Mariscal Harana, Arna van Engelen, Torben Schneider, Mateusz Florkow, Peter Charlton, Bram Ruijsink, Hubrecht De Bliek, Israel Valverde, Marietta Carakida, Kuberan Pushparajah, Spencer Sherwin, Rene Botnar, Jordi Alastruey
Pages: 54 - 55
Background and objectives: Clinical evidence shows that central (aortic) blood pressure (CBP) is a better marker of cardiovascular risk than brachial pressure [1]. However, CBP can only be accurately measured invasively, through catheterisation. We propose a novel approach to estimate CBP non-invasively...
Ekaterina Belozertseva, Huguette Louis, Zhenlin Li, Mustapha Bourhim, Dominique Dumas, Veronique Regnault, Patrick Lacolley
Pages: 54 - 55
Integrin αv functions as a receptor for adhesion proteins and is expressed at high density in vascular smooth muscle cells (VSMC)1,2,3,4,5 whose phenotypic modulation plays a crucial role in arterial ageing and atherosclerosis.6,7.
Our aim was to define the arterial phenotype in mice conditionally inactivated...
M. Reimann, H.W. Huisman, R. Schutte, L. Malan, J.M. van Rooyen, A.E. Schutte
Pages: 54 - 54
M. Patraulea, O. Mayer, M. Dolejsova, J. Filipovsky
Pages: 54 - 54
K.M.S. AlHashmi, H.K. Parthasarathy, A.D. McMahon, A.D. Struthers, T.M. MacDonald, I. Ford, G.T. McInnes, J.M.C. Connell
Pages: 54 - 55
A. Miyaji, T. Ikemura, Y. Hamada, N. Hayashi
Pages: 54 - 59
Background: It is well-known that cerebral and ocular vessels are highly sensitive to changes in the partial pressure of CO2 (PETCO2). However, it is unclear whether there are regional differences in the magnitude of the vascular response to CO2 (CO2 reactivity) in various vessels of a single individual,...
Jitka Seidlerová, Jan Filipovský, Otto Mayer, Renata Cífková, Martin Pešta, Radek Blatný, Jiří Vaněk
Pages: 54 - 59
Background: Recently, rs3918226 polymorphism in the promoter region of endothelial NO synthase (eNOS) was strongly associated with arterial hypertension in a large genome-wide association study. We investigated whether this polymorphism was associated with arterial phenotypes in a Czech general population.
Methods:...
Luc M. Van Bortel
Pages: 54 - 55
Louise Marais, Mathieu Pernot, Hakim Khettab, Michael Tanter, Emmanuel Messas, Mustapha Zidi, Stéphane Laurent, Pierre Boutouyrie
Pages: 55 - 55
Objective: Because measurement of arterial stiffness is highly dependent on blood pressure (BP), methods independent of BP are required. Shear wave elastography (SWE, Supersonic Imagine, Aix-en-Provence, France) enables to assess local tissue stiffness by tracking the propagation of shear waves generated...
Stephanie Parragh, Bernhard Hametner, Christopher Mayer, Siegfried Wassertheurer, Thomas Weber
Pages: 55 - 55
Objectives: Parameters of aortic stiffness are considered important indicators of cardiovascular risk. However, in heart failure with reduced ejection fraction (HFrEF), their association to outcome was found to be inversed. The aim of this work was to analyze the relationship of the amplitude of reservoir...
I. Klefortova, M. Shamkhalova, A. Bukhman, O. Remizov, M. Shestakova, D. Ustyuzhanin, M. Sharia, E. Tugeeva, U. Buziashvili
Pages: 55 - 55
Hannah Safi, Nathan Phillips, Yiannis Ventikos, Richard Bomphrey
Pages: 55 - 56
An Abdominal Aortic Aneurysm (AAA) represents a degenerative disease process of the abdominal aorta that leads to a focal dilation and irreversible remodeling of the arterial wall [1].
The reliable assessment of AAA rupture risk in a clinical setting is crucial in decreasing related mortality without...
Arthur Le Gall, Jona Joachim, Joaquim Mateo, Alexandre Mebazaa, Etienne Gayat, Fabrice Vallée
Pages: 55 - 56
Purpose/Background/Objectives: Cardiac afterload evaluation is crucial during general anesthesia (GA) especially during hypotension episode. Using beat to beat aortic pressure (P) / flow velocity (U) loop constructed from routine signals recorded during GA might allow to track afterload changes.
Methods:...
O. Mayer, J. Filipovský, M. Pešta, J. Hrbková, M. Dolejšová
Pages: 55 - 55
O. Mayer, J. Filipovský, M. Dolejšová, L. Handl
Pages: 55 - 55
Jonathan P. Mynard, Joseph J. Smolich
Pages: 55 - 63
Models of haemodynamics play a central role in current research directed to understanding and addressing cardiovascular disease. Although conventional windkessel and wave models are very useful, they are incompatible due to conflicting assumptions and neither comprehensively explain the basis and interdependencies...
Magid Hallab, Pascal Chevalet, Amine Dahou, Gilles Berrut
Pages: 55 - 57
Purpose: In order to determine if the height of a subject could be a reliable surrogate variable to determine the pulse wave travelling distance within the aorta, we investigated the anatomical distance between the aortic valve nidus and the hyoid bone.
Methods: Using 28 patient’s chest CT-scans. From...
Filippo Valbusa, Andrea Angheben, Verena Zerbato, Andrea Chiampan, Davide Agnoletti, Cristiano Fava, Zeno Bisoffi, Guido Arcaro
Pages: 56 - 56
Background: In Italy, the prevalence of seropositivity for Trypanosoma cruzi in immigrants from endemic countries is about 11.3% (30.7% for Bolivian immigrants).
The disease acute phase is usually asymptomatic, often leading to chronic infection that may remain silent for life (chronic indeterminate...
Pierre Boutouyrie, Hakim Khettab, David Campo, Roger Yu, Nadine Buard
Pages: 56 - 56
Background: Measurement of arterial stiffness (AS) is still considered difficult. We developed a non-invasive technique to assess AS from a connected bathroom scale, based on ballistocardiography (BCG) and impedance plethysmography (IPG).
Methods: We included 198 subjects and patients, 111 for calibration...
A. Cypiene, A. Laucevicius, A. Venalis, J. Dadoniene, R. Rugiene, L. Ryliskyte, Z. Petrulioniene, M. Kovaite, V. Skorniakov
Pages: 56 - 56
Christian Delles, Sarah McNeilly, Sheon Mary, Adam Sheikh, Heather Small
Pages: 56 - 56
Background: Premenopausal women are relatively protected against hypertension compared to males. Estrogen levels have been identified as a potential underlying cause, but the pathophysiological mechanisms remain incompletely understood. We hypothesised that sex-dependent effects of perivascular adipose...
Pauliina Kangas, Anna Tahvanainen, Antti Tikkakoski, Jenni Koskela, Marko Uitto, Jari Viik, Mika Kahonen, Tiit Koobi, Emeritus Jukka Mustonen, Ilkka Porsti
Pages: 56 - 56
Background: Men and women differ in the risk of cardiovascular disease, but the underlying mechanisms are not completely understood. We examined possible sex-related differences in supine and upright cardiovascular regulation.
Methods: Hemodynamics were recorded from 167 men and 167 women of matching...
S. Dogan, Y. Plantinga, J.M. Dijk, Y. van der Graaf, D.E. Grobbee, M.L. Bots
Pages: 56 - 56
Hirofumi Tomiyama, Akira Yamashina, Shunsuke Komatsu, Kazuki Shiina, Chisa Matsumoto, Shogen Fujii, Taishiro Chikamori
Pages: 56 - 56
Objectives: It is noted that not only arterial stiffness but also abnormal pressure wave reflection are risks for the development of hypertension. However, the association between arterial stiffness and pressure wave reflection in the development of hypertension has not been fully clarified. The present...