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2992 articles
Conference Abstract

05.01 CAN WAVE INTENSITY HELP EXPLAIN THE DIFFERENT VELOCITY FLOW PROFILES IN THE CORONARY ARTERIES?

N. Hadjiloizou, J. Davies, D. Francis, A.J. Baksi, K. Parker, A. Hughes, J. Mayet
Pages: 48 - 48
Conference Abstract

05.02 HERITABILITY AND INTRAFAMILIAL AGGREGATION OF ARTERIAL CHARACTERISTICS

J.S. Seidlerova, J.A.S. Staessen, M.B. Bochud, M.C. Cwynar, M.D. Dolejsova, T.K. Kuznetsova, T.N. Nawrot, A.O. Olszanecka, K.S. Stolarz, L.T. Thijs, W.W. Wojciechowska, HAS.-B. Struijker-Boudier, KK.-J. Kawecka-Jaszcz, R.C.E. Elston, R.F. Fagard, J.F. Filipovsky
Pages: 48 - 49
Research Article

Correlation between Neck Circumference and Pulse Wave Velocity: A Population-based Study

Larissa Ribeiro Bessa, Luís Antônio Bahiana Cruz, Rodrigo Lins Sant’Ana de Lima, Maria Cristina Lima Fontenele Presta, Antonio de Assis Oliveira Alves Filho, Roberta de Castro Araújo Cunha, Alana dos Reis Silva, Juan Jailson Oliveira Almeida Costa, Cecília Freitas da Silva Araújo, Diorlene Oliveira da Silva, Lucélia Batista Neves Cunha Magalhães
Pages: 48 - 55
Background: Cardiovascular diseases are the main cause of death worldwide. In this setting, Neck Circumference (NC) and Pulse Wave Velocity (PWV) are simple and valuable tools for an early evaluation of cardiovascular risk through the assessment of upper body obesity and arterial stiffness. However,...
Research Article

Design and progress of a factorial trial testing the effect of spironolactone and inorganic nitrate on arterial function in people at risk of or with type 2 diabetes

Charlotte E. Mills, Virginia Govoni, Maria Linda Casagrande, Luca Faconti, Andrew J. Webb, J. Kennedy Cruickshank
Pages: 48 - 53
Background: Arterial stiffness (AS), as pulse wave velocity (PWV), is a powerful independent predictor of cardiovascular events and commonly complicates type 2 diabetes (T2D). This trial aims to test if AS, measured by the VaSera machine as cardio-ankle vascular index (CAVI) and by Arteriograph measuring...
Research Article

The cardio-ankle vascular index predicts chronic kidney disease in Japanese subjects

Daisuke Maebuchi, Munehisa Sakamoto, Jun Fuse, Hiroaki Tanaka, Yasuyuki Shiraishi, Makoto Takei, Yumiko Inui, Yuumi Sutoh, Yukinori Ikegami, Yukihiko Momiyama
Pages: 48 - 53
Objective: Chronic kidney disease (CKD) is known to be associated with the incidence and mortality of cardiovascular disease. Therefore, the prevention of CKD may improve the mortality of cardiovascular disease. The risk factors of CKD are variable and multifactorial, similar to atherosclerosis. We hypothesized...
Conference Abstract

NAA1 NICOTINAMIDE RIBOSIDE SUPPLEMENTATION REDUCES AORTIC STIFFNESS AND BLOOD PRESSURE IN MIDDLE-AGED AND OLDER ADULTS

Christopher Martens, Blair Denman, Melissa Mazzo, Michael Armstrong, Nichole Reisdorph, Matthew McQueen, Michel Chonchol, Douglas Seals
Pages: 49 - 49
Purpose: Regular calorie restriction (CR) improves endothelial function and lowers aortic stiffness in older mice and humans; however, adherence to sustained CR remains poor, and possibly unsafe in normal weight older adults. Nicotinamide adenine dinucleotide (NAD+) is an important signaling molecule...
Conference Abstract

2.1 THE RELATIVE IMPORTANCE OF CENTRAL AND BRACHIAL BLOOD PRESSURE IN PREDICTING CARDIOVASCULAR EVENTS: AN INDIVIDUAL PARTICIPANT META-ANALYSIS OF PROSPECTIVE OBSERVATIONAL DATA FROM 22,433 SUBJECTS

Carmel McEniery, Yoav Ben-Shlomo, Margaret May, Melissa Spears, Lyndia Brumback, James Cameron, Chen-Huan Chen, Julio Chirinos, Danuta Czarnecka, Anthony Dart, Richard Devereux, Neeraj Dhaun, Daniel Duprez, Shih-Jen Hwang, David Jacobs, Piotr Jankowski, Julie Janner, Peter Lacy, Gary Mitchell, Riccardo Pini
Pages: 49 - 49
Systolic blood pressure (SBP) differs between the brachial artery and aorta. Prospective data suggest that central pressure predicts future cardiovascular events, but it is unclear if it is superior to brachial pressure. Methods and Results: A systematic review and individual participant data meta-analysis...
Conference Abstract

05.03 OSTEOPROTEGERIN IS RELATED TO CAROTID-FEMORAL PULSE WAVE VELOCITY AND SURVIVAL IN HEMODIALYSIS PATIENTS

J. Nemcsik, B.C.S. Fekete, G. Speer, G. Bakonyi, J. Egresits, E. Fodor, T.E.H. Othmane, A. Szabo, I. Kiss, A. Tisler
Pages: 49 - 49
Conference Abstract

LAA1 HEMODYNAMIC AND STRUCTURAL ARTERIAL PARAMETERS’ ASSOCIATION WITH INTERINDIVIDUAL VARIATIONS OF BODY MASS INDEX IN CHILDHOOD AND ADOLESCENCE

Victoria Garcia, Santiago Curcio, Agustina Zinoveev, Gustavo Giachetto, Pedro Chiesa, Daniel Bia, Yanina Zócalo
Pages: 49 - 50
Background: Several works analyze arterial parameters’ (stiffness levels, wall thickness, etc.) association with variations of body mass index (BMI) in pediatric populations. However, none integrate different arterial parameters as comparable continuous (standardized) variables, in order to assess their...
Conference Abstract

2.2 CENTRAL-TO-PERIPHERAL DIASTOLIC BLOOD PRESSURE ATTENUATION IN HEALTHY ADOLESCENTS AND THE EFFECTS OF HEART RATE. THE MACISTE STUDY

Giacomo Pucci, Francesca Battista, Leandro Sanesi, Sara Alessio, Giuseppe Schillaci
Pages: 49 - 49
Background: Heart rate (HR) is directly associated to central-to-peripheral pulse wave amplification. We aimed at evaluating the associations between heart rate and each BP component in a cohort of healthy adolescents. Objective: 470 healthy adolescents (17±1.4 years, 56% boys, brachial BP 123/67±11/7...
Conference Abstract

05.04 ACUTE EFFECTS OF PASSIVE SMOKING ON PERIPHERAL VASCULAR FUNCTION

D. Adamopoulos, J.F. Argacha, M. Gujic, N. Amai, D. Fontaine, G. Berkenboom, P. van de Borne
Pages: 49 - 49
Conference Abstract

2.3 DETERMINANTS OF INAPPROPRIATELY HIGH PULSE WAVE VELOCITY IN HYPERTENSIVE PATIENTS: A RETROSPECTIVE CROSS-SECTIONAL COHORT STUDY

Marina Di Pilla, Rosa Maria Bruno, Simona Buralli, Melania Sgro’, Piero Amedeo Modesti, Stefano Taddei, Lorenzo Ghiadoni
Pages: 49 - 50
Background: Age and blood pressure (BP) are known to be the main determinants of large artery stiffness. However other factors may lead to an inappropriately high pulse wave velocity (PWV). We investigated the determinants of inappropriately high PWV in hypertensive patients and their possible role in...
Conference Abstract

06.01 THE INFLUENCE OF CARDIOVASCULAR DISEASE AND RISK FACTORS ON AGE-RELATED CHANGES IN AORTIC PULSE WAVE VELOCITY

C.M. McEniery, Y. Yasmin, M. Munnery, S.M.L. Wallace, B. McDonnell, K.M. Maki-Petaja, S. Hickson, J.R. Cockcroft, I.B. Wilkinson
Pages: 49 - 50
Research Article

Integrated Central Blood Pressure-aortic Stiffness Risk Categories and Cardiovascular Mortality in End-stage Renal Disease

Dóra Batta, Ádám Tabák, Beáta Kőrösi, Orsolya Cseprekál, József Egresits, András Tislér, János Nemcsik
Pages: 49 - 55
Background: Our aim was to study the predictive power of integrated central blood pressure-aortic stiffness (ICPS) risk categories on cardiovascular (CV) mortality in end-stage renal disease (ESRD) patients. Methods: This is a secondary analysis of a prospective study of 91 ESRD patients on hemodialysis...
Research Article

Prostaglandin E1 for preventing the progress of pulmonary arterial hypertension in rat model

Jae Chul Lee, Soo Young Choe, Chan Yeong Heo, Sun Ju Jeong
Pages: 49 - 56
Pulmonary artery hypertension (PAH) is a progressive chronic disease with a high mortality rate. Increased pulmonary vascular resistance and over-proliferation of pulmonary artery endothelial cells lead to remodeling of pulmonary vasculature. Several anti-PAH therapies targeting various pathways involved...
Research Article

The implications of poor sleep quality on arterial health in persons with multiple sclerosis

Brooke M. Shafer, Sushant M. Ranadive, Tracy Baynard, Robert W. Motl, Bo Fernhall
Pages: 49 - 55
Background: Multiple sclerosis (MS) is associated with increased risk of cardiovascular disease (CVD) and approximately 25–54% of patients report poor sleep quality. There is evidence from the general population of an association between poor sleep and increased CVD risk, but this is poorly understood...
Review Article

Practical solutions for hypertensive patients with dyslipidemia☆

Charalambos Vlachopoulos, Nikolaos Ioakeimidis
Pages: 49 - 54
Arterial hypertension and dyslipidemia often coexist and constitute major risk factors of ischemic heart disease. Aggressive treatment of both comorbidities is of paramount importance to decrease global risk. Low adherence is a determinant of poor risk factor control and increases adverse cardiovascular...
Research Article

The association between aortic regurgitation and increased arterial wave reflection

Haroon Kamran, Louis Salciccioli, Carl-Frederic Bastien, Abhishek Sharma, Jason M. Lazar
Pages: 49 - 54
Background: Chronic Aortic Regurgitation (AR) increases left ventricular preload and afterload, which may enhance arterial wave reflection. The effects of AR on noninvasive measures of arterial wave reflection and central aortic pressure are unknown. Methods: To determine the relation between AR and...
Short Communication

Arterial calcification in rheumatoid arthritis

Veli Yazisiz, Ali Berkant Avci, Ender Terzioğlu
Pages: 49 - 50
Arterial calcification most often occurs in patients with end-stage renal disease who undergo hemodialysis or hyperparathyroidism and it is independently associated with cardiovascular events and death. Calciphylaxis is uncommon in patients with rheumatoid arthritis. We present here development of arterial...
Conference Abstract

2.1 COGNITION IN RELATION TO THE RETINAL MICROCIRCULATION IN CHILDREN BORN PREMATURELY OR AT TERM

Fangfei Wei, Anke Raaijmakers, Zhen-Yu Zhang, Theun Pieter van Tienoven, Qi-Fang Huang, Wen-Yi Yang, Lutgarde Thijs, Harry Struijker-Boudier, Peter Verhamme, Karel Allegaert, Jan Staessen
Pages: 50 - 50
Background: The retinal microvasculature can be visualized noninvasively and mirrors the status of the cerebral vasculature. We therefore investigated in 93 prematurely born infants (birth weight < 1000 g) and 87 controls born at term whether neurocognitive performance at ∼11 years is associated with...
Conference Abstract

2.4 SODIUM CONSUMPTION, CENTRAL AND PERIPHERAL BLOOD PRESSURE, AND FOOD HABITS IN A POPULATION OF HEALTHY ADOLESCENTS. THE MACISTE STUDY

Giacomo Pucci, Francesca Battista, Marco D’Abbondanza, Leandro Sanesi, Giuseppe Schillaci
Pages: 50 - 50
Objective: The relationship between sodium consumption, central BP and the main dietary sources of daily sodium intake in adolescence has been poorly explored. We have evaluated sodium intake, central and peripheral BP in a population of Italian adolescents. Methods: 401 healthy adolescents aged 17±1...
Conference Abstract

06.02 AORTIC AND CAROTID STIFFNESS IN OLDER ADULTS. THE ROTTERDAM STUDY

F.U.S. Mattace-Raso, N.M. van Popele, A. Hofman, J.C.M. Witteman
Pages: 50 - 50
Conference Abstract

2.2 HEART STRUCTURE AND VASCULAR FUNCTION IN YOUNG PATIENTS AFTER ENDOVASCULAR REPAIR FOR BLUNT THORACIC AORTIC INJURY

Paola Vallerio, Ilenia D’Alessio, Alessandro Maloberti, Marisa Varrenti, Simone Maggioni, Valentina Cantu, Marco Carbonaro, Maria Cristina Ferrara, Elisa Spada, Bruno Palmieri, Alfredo Lista, Cristina Giannattasio
Pages: 50 - 50
Objective: Thoracic Endovascular Aortic Repair (TEVAR) currently represents the gold standard of treatment for Blunt Thoracic Aortic Injury (BTAI). Nevertheless, there is an ongoing debate surrounding its safety and efficacy and its subsequent CV effects. The present study is aimed at assessing heart...
Conference Abstract

2.5 THE EFFECT OF RENAL DENERVATION ON CENTRAL BLOOD PRESSURE AND ARTERIAL STIFFNESS IN TREATMENT RESISTANT ESSENTIAL HYPERTENSION: A SUBSTUDY OF A RANDOMIZED SHAM-CONTROLLED DOUBLE-BLINDED TRIAL (THE RESET TRIAL)

Christian D. Peters, Ole N. Mathiasen, Henrik Vase, Jesper Bech, Kent L. Christensen, Anne P. Schroeder, Ole Lederballe, Hans Rickers, Ulla Kampmann, Per L. Poulsen, Sten Langfeldt, Gratien Andersen, Klavs W. Hansen, Hans E. Bøtker, Morten Engholm, Jannik B. Bertelsen, Jens F. Lassen, Erling B. Pedersen, Anne Kaltoft, Niels H. Buus
Pages: 50 - 50
Background: A recent sham-controlled trial (ReSET) showed no sustained effect of renal denervation (RDN) on 24-hour ambulatory blood pressure (24hA-BP) measurements in patients with treatment resistant hypertension.1 The aim of this substudy was to investigate, whether RDN affects central blood pressure...
Conference Abstract

2.3 BIOMECHANICAL AND STRUCTURAL QUANTIFICATION OF VASCULAR DAMAGE: A UNIQUE INVESTIGATION OF STENT IMPLANTATION

Markus A. Geith, Gerhard Sommer, Thomas Schratzenstaller, Gerhard A. Holzapfel
Pages: 50 - 50
The most challenging complication after coronary stent implantation is in-stent restenosis [1], which is mainly caused by mechanically induced injuries due to overloading. From a biomechanical point of view, the processes occurring inside the arterial tissues during stent implantation (SI) is rather...
Conference Abstract

2.7 NON-INVASIVE EVALUATION OF END SYSTOLIC LEFT VENTRICULAR ELASTANE ACCORDING TO PRESSURE-VOLUME CURVE MODELLING DURING EJECTION IN ARTERIAL HYPERTENSION

Benjamin Bonnet, Frank Jourdan, Guilhem du Cailar, Pierre Fesler
Pages: 50 - 50
Objective: Non invasive methods have been proposed to assess end systolic left ventricular (LV) elastance (Ees), but clinical application remains complex. The aim of the present study was to 1) estimate Ees according to modeling of LV pressure-volume (P-V) curve during ejection and validate our method...
Conference Abstract

06.04 NON-ALCOHOLIC FATTY LIVER DISEASE IS ASSOCIATED WITH IMPAIRED SECRETION OF FAT PRODUCED HORMONES AND INCREASED CARDIOVASCULAR RISK

K. Baou, C. Vlachopoulos, E. Manesis, N. Ioakeimidis, G. Papatheodoridis, J. Koskinas, A. Archimandritis, C. Stefanadis
Pages: 50 - 50
Research Article

Histopathology and histomorphometry of umbilical cord blood vessels. Findings in normal and high risk pregnancies☆

Manuel Vázquez Blanco, Hilda Ruda Vega, Roberto A. Guerri-Guttenberg, Rodolfo Giuliano, Daniel R. Grana, Francisco Azzato, José Milei
Pages: 50 - 57
Objective: A systematic histological, morphometric and immunohistochemical (PAI-1 and TGF-β1) study of umbilical vessels in normal and pathological conditions was undertaken in order to describe and compare the lesions found. Methods: Segments of umbilical cords were obtained from 92 pregnancies/107...
Conference Abstract

2.4 BRACHIAL CUFF RESERVOIR CHARACTERISTICS AND END-ORGAN MARKERS OF CARDIOVASCULAR RISK IN AUSTRALIAN ADULTS: A CROSS-SECTIONAL STUDY

Xiaoqing Peng, Martin Schultz, Michael Cheung, Melissa Wake, Jonathan Mynard, David Burgner, Richard Liu, James Sharman
Pages: 51 - 51
Objective: Reservoir-excess pressure measured using tonometry methods predicts cardiovascular events, but the operator-dependency of tonometry is an impediment to widespread use. A cuff-based blood pressure device has been developed to derive reservoir-excess pressure from measured brachial pressure...
Conference Abstract

3.1 REDUCING ARTERIAL STIFFNESS INDEPENDENTLY OF BP: PROOF OF CONCEPT? CAVI, PWV AND CARDIAC DATA IN THE 6-MONTH VASERA TRIAL

Charlotte Mills, Luca Faconti, Virginia Govoni, Steve Morant, Maria-Linda Casagrande, Haotian Gu, Benyu Jiang, Andrew Webb, Kennedy Cruickshank
Pages: 51 - 51
Purpose/ background/ objectives: People with or at risk of Type II diabetes (T2DM) are at increased risk of vascular disease and arterial stiffness (AS). We hypothesized that spironolactone and dietary nitrate (beetroot juice) separately and together would reduce AS, measured as cardiac-ankle vascular...
Conference Abstract

2.5 NON-INVASIVE WAVE INTENSITY ANALYSIS IN THE AORTA AND INTERNAL CAROTID USING PHASE-CONTRAST MR ANGIOGRAPHY: THE EFFECT OF HYPERTENSION

Sandra Neumann, Mark Hamilton, Julian Paton, Angus Nightingale, Jonathan Brooks, Emma Hart, Giovanni Biglino
Pages: 51 - 51
Introduction: Hypertension is associated with stiffening of blood vessels, reduced arterial lumen and reduced cerebral blood flow; however, it is not known how lower cerebral blood flow relates to arterial structure or impacts on wave dynamics. We hypothesise increased backward wave energy and faster...
Conference Abstract

3.2 VARIABILITY IN MEAN ARTERIAL PRESSURE AND DIASTOLIC BLOOD PRESSURE FROM CENTRAL TO PERIPHERAL LARGE ARTERIES: RELEVANCE TO ARTERIAL PHYSIOLOGY AND ESTIMATED CENTRAL BLOOD PRESSURE

Martin Schultz, Dean Picone, Xiaoqing Peng, Andrew Black, Nathan Dwyer, Phillip Roberts-Thomson, James Sharman
Pages: 51 - 51
Background: Mean arterial pressure (MAP) and diastolic blood pressure (DBP) are thought to consistently decline approximately 1–3 mmHg from the aorta to peripheral large arteries, thus providing a small pressure gradient to aid blood flow. The magnitude of this gradient is important for correct waveform...
Conference Abstract

06.06 ARTERIAL STIFFNESS AND ENLARGEMENT IN MILD TO MODERATE CHRONIC RENAL FAILURE: ROLE OF VITAMIN D

M. Briet, P. Houillier, M. Froissart, E. Bozec, C. Gaucci, C. Collin, S. Laurent, P. Boutouyrie
Pages: 51 - 51
Conference Abstract

2.6 BLOOD PRESSURE-INDEPENDENCE OF AORTIC-TO-BRACHIAL ARTERY STIFFNESS RATIO IS DEPENDENT ON DISEASE STATUS

Matthew K. Armstrong, Martin G. Schultz, Dean S. Picone, James E. Sharman
Pages: 51 - 52
Introduction: Aortic stiffness predicts cardiovascular mortality but is limited as a risk marker because it is dependent on blood pressure (BP). A potential solution is provided from the ratio of aortic-to-brachial artery stiffness (ab-ratio), which is purported to be a BP-independent risk marker among...
Conference Abstract

3.3 DISCOVERY OF A NEW BLOOD PRESSURE PHENOTYPE FROM INVASIVE CENTRAL-TO-PERIPHERAL RECORDINGS: IMPLICATIONS FOR BRACHIAL CUFF ACCURACY AND CARDIOVASCULAR RISK ASSESSMENT

Dean Picone, Martin Schultz, Xiaoqing Peng, Andrew Black, Nathan Dwyer, Phil Roberts-Thomson, Velandai Srikanth, James Sharman
Pages: 51 - 51
Background: Accuracy of brachial cuff blood pressure (BP) may be influenced by individual variability in central-to-peripheral systolic BP (SBP)-amplification, but this has never been determined. We aimed to achieve this by characterising SBP-amplification phenotypes and examining associations with cuff...
Conference Abstract

06.07 EVALUATION OF A METHOD OF WAVE REFLECTION ASSESSMENT VIA TRIANGULAR FLOW WAVE APPROXIMATION

J.G. Kips, E.R. Rietzschel, M.L. De Buyzere, T.C. Gillebert, L.M. Van Bortel, P. Segers
Pages: 51 - 51
Conference Abstract

3.4 WAVE INTENSITY ANALYSIS PROVIDES NOVEL INSIGHTS INTO PULMONARY HYPERTENSION

Junjing Su, Charlotte Manisty, Kim H. Parker, Soren Mellemkjaer, Luke Howard, Ulf Simonsen, Alun Hughes
Pages: 51 - 52
Background: The objective of the study was to apply wave intensity analysis (WIA) in the pulmonary artery to characterise the magnitude, origin, type and timing of arterial waves in individuals with and without pulmonary hypertension (PH). Methods: Right heart catheterisation was performed using a pressure...
Conference Abstract

06.08 RELATIONSHIP BETWEEN PULSE WAVE VELOCITY AND DIFFERENT BLOOD PRESSURE PATTERNS: THE VOBARNO STUDY

A. Paini, M.L. Muiesan, M. Salvetti, C. Corbellini, E. Belotti, G. Galbassini, C. Agabiti-Rosei, C. Aggiusti, L. Micheletti, V. Paderno, E. Agabiti-Rosei
Pages: 51 - 51
Review Article

Waves in arteries: A review of wave intensity analysis in the systemic and coronary circulations

Alun D. Hughes, Kim H. Parker, Justin E. Davies
Pages: 51 - 59
The intermittent ejection of blood by the ventricle results in pulsatile pressure and flow waveforms in the circulation. Understanding and characterizing this pulsatile behaviour is attracting increasing clinical interest, as it may have important implications for risk prediction and the mechanisms of...
Research Article

A comparative study on the mechanical properties of the umbilical vein and umbilical artery under uniaxial loading

Alireza Karimi, Mahdi Navidbakhsh, Mansour Alizadeh, Ahmad Shojaei
Pages: 51 - 56
Purpose: Coronary Artery Disease (CAD) is the main cause of mortalities worldwide. The Saphenous Vein (SV) and Umbilical Vein (UV) are the most common veins using for treatment as a Coronary Artery Bypass Graft (CABG). The mechanical properties of UV owing to its long-term patency for CABG are deemed...
Conference Abstract

2.7 THE GUT-DERIVED METABOLITE TRIMETHYLAMINE N-OXIDE INDUCES LARGE ELASTIC ARTERY STIFFENING AND ENDOTHELIAL DYSFUNCTION IN YOUNG MICE

Vienna Brunt, Rachel Gioscia-Ryan, Zachary Sapinsley, Melanie Zigler, James Richey, Douglas Seals
Pages: 52 - 52
The gut microbiome, an emerging mediator of host physiological function, is adversely altered by aging and many diseases, termed “gut dysbiosis.” One consequence of gut dysbiosis is elevated circulating levels of the gut-derived metabolite trimethylamine N-oxide (TMAO), which has been directly linked...
Conference Abstract

3.5 NON-INVASIVE US-BASED WAVE INTENSITY ANALYSIS IN MICE

Nicole Di Lascio, Claudia Kusmic, Francesco Stea, Francesca Lenzarini, Francesco Faita
Pages: 52 - 52
Wave Intensity Analysis (WIA) can provide information about the interaction between vascular and cardiac system. WIA-derived indexes have quantitative physiological meaning. We investigated age-associated changes in WIA-derived parameters in mice and correlated them with biomarkers of cardiac function. Sixteen...
Conference Abstract

2.8 INVASIVE STUDY FOR TESTING NON-INVASIVE METHODS OF AORTIC PRESSURE ESTIMATION

Andrea Guala, F. Tosello, D. Leone, L. Sabia, F. D’Ascenzo, T. Crea, C. Moretti, F. Gaita, F. Veglio, L. Ridolfi, A. Milan
Pages: 52 - 52
Purpose: Aortic blood pressure has a superior prognostic value with respect to the brachial pressure [ 1]. Nonetheless, the low efficacy of the most used non-invasive methods (i.e., approaches based on the generalized transfer function (GTF)) may hamper the detection of this superiority in population...
Conference Abstract

3.6 LONGITUDINAL CHANGES IN AORTIC RESERVOIR FUNCTION INDEPENDENTLY PREDICT DECLINING RENAL FUNCTION AMONG HEALTHY INDIVIDUALS

Rachel Climie, Dean Picone, James Sharman
Pages: 52 - 52
Objectives: Aortic reservoir function independently predicts end organ damage in cross sectional analyses. However, longitudinal associations are more important regarding causation, but this has never been examined and was the goal of this study. Methods: Aortic reservoir function (excess pressure integral...
Conference Abstract

3.1 INTEGRATED CENTRAL PRESSURE-STIFFNESS RISK SCORE: A NEW OPPORTUNITY FOR CARDIOVASCULAR RISK STRATIFICATION. FIRST RESULTS ON CHRONIC KIDNEY DISEASE PATIENTS

János Nemcsik, Orsolya Cseprekál, Ádám Tabák, Dóra Batta, József Egresits, István Kiss, András Tislér
Pages: 52 - 53
Background: The evaluation of arterial stiffness and central haemodynamics represent a new tool of cardiovascular (CV) risk stratification. Our aim was to create an integrated central pressure-stiffness risk score (ICPS score) which incorporate the predictive potential of identical parameters. Methods:...
Conference Abstract

3.7 ARTERIAL STIFFNESS FOR THE EARLY PREDICTION OF PRE-ECLAMPSIA COMPARED WITH CLINICAL CHARACTERISTICS, UTERINE ARTERY DOPPLER INDICES, AND ANGIOGENIC BIOMARKERS

Kim Phan, Yessica Haydee Gomez, Jessica Gorgui, Amira El-Messidi, Robert Gagnon, Stella Daskalopoulou
Pages: 52 - 52
Objective: To develop a model for the 1st trimester prediction of pre-eclampsia. Methods: In this prospective longitudinal study, women with high-risk singleton pregnancies were recruited and arterial stiffness was measured using applanation tonometry (SphygmoCor, AtCor) and compared between women who...
Conference Abstract

3.8 CAN ARTERIAL WAVE AUGMENTATION IN YOUNG ADULTS EXPLAIN VARIABILITY OF CARDIOVASCULAR RISK IN ETHNIC MINORITIES?

Luca Faconti
Pages: 52 - 53
Objective: Traditional cardiovascular (CV) risk factors do not fully explain ethnic differences in CV disease [1,2]. We tested if pulse wave velocity (PWV) and Augmentation Index (AIx) and their determinants from childhood may underlie ethnic variability in CV risk as young adults in the ‘DASH’ longitudinal...
Short Communication

Sex differences in aortic stiffness following acute resistance exercise

Jacqueline A. Augustine, Wesley K. Lefferts, Kevin S. Heffernan
Pages: 52 - 55
Research Article

Oxidative stress and arterial stiffness in strength- and endurance-trained athletes

Youngju Choi, Seiji Maeda, Takeshi Otsuki, Asako Miyaki, Nobutake Shimojo, Mutsuko Yoshizawa, Hitoshi Shiraki, Ryuichi Ajisaka
Pages: 52 - 58
Background: Endurance exercise training decreases arterial stiffness, whereas high-intensity strength exercise training increases arterial stiffness. However, the mechanisms underlying the adaptations to the 2 types of exercise training remain unclear. Increased oxidative stress induces vasoconstriction...
Conference Abstract

3.2 ASCENDING AND DESCENDING AORTA PULSE WAVE VELOCITY AND DISTENSIBILITY IN BICUSPID AORTIC VALVE PATIENTS

Andrea Guala, Jose Rodriguez-Palomares, Lydia Dux-Santoy, Gisela Teixido-Tura, Giuliana Maldonado, Nicolas Villalva, Filipa Valente, Laura Galian, Marina Huguet, Laura Gutierrez, Teresa Gonzalez, Ruben Fernandez, Augusto Sao-Aviles, David Garcia-Dorado, Artur Evangelista
Pages: 53 - 53
Purpose: Bicuspid aortic valve (BAV) is a cardiac congenital disease associated with ascending aorta (AAo) dilation. The study of the impact of aortic biomechanics in this population has been limited by technical difficulties. Contrasting results have been reported for distensibility while studies including...
Conference Abstract

3.9 ASSOCIATIONS OF BLOOD PRESSURE THROUGHOUT CHILDHOOD WITH LEFT VENTRICLE MASS IN ADOLESCENCE

Chloe Park, Nish Chaturvedi, Alun Hughes
Pages: 53 - 53
Background: High blood pressure (BP) is a major risk factor for elevated LV mass (LVM) in adults. Evidence suggests that BP tracks from childhood into adolescence and adulthood, however findings on the association between childhood BP and LVM are inconsistent and the temporal relationship between BP...
Conference Abstract

P.001 ACUTE EFFECTS OF NICOTINE ON PERIPHERAL AND CORONARY VASCULAR FUNCTION IN YOUNG NON-SMOKERS

D. Adamopoulos, J.F. Argacha, M. Gujic, C. Garcia, N. Preumont, J.P. Degaute, S. Goldman, P. van de Borne
Pages: 53 - 53
Conference Abstract

3.3 ASSESSMENT OF AORTIC MORPHOLOGY IN A BICUSPID AORTIC VALVE POPULATION

Froso Sophocleous, Benedetta Biffi, Elena Giulia Milano, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli, Chiara Bucciarelli-Ducci, Tom Gaunt, Silvia Schievano, Giovanni Biglino
Pages: 53 - 54
Background: Bicuspid aortic valve (BAV) is a congenital heart disease associated with aortic wall abnormalities and co-existing with other congenital defects (e.g. aortic coarctation). This study aimed to explore aortic shape features in a BAV population, identifying sub-groups with different aortic...
Conference Abstract

4.1 TNF- ANTAGONISTS IMPROVE ARTERIAL STIFFNESS IN PATIENTS WITH RHEUMATOID ARTHRITIS: A META-ANALYSIS

Georgios Georgiopoulos, Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Athanasios Gravos, Panagiota Pietri, Christos Georgakopoulos, Kimon Stamatelopoulos, Dimitrios Tousoulis
Pages: 53 - 54
Purpose/Background/Objectives: Patients with rheumatoid arthritis (RA) have a higher arterial stiffness than their age-matched healthy counterparts and an increased inflammatory burden that might be associated with their increased cardiovascular risk. Tumor necrosis factor alpha (TNF)-antagonists have...
Conference Abstract

P.002 HABITUAL ANTIOXIDANT VITAMIN INTAKE, AUGMENTATION INDEX AND FLOW MEDIATED DILATION IN HYPERTENSIVE PATIENTS AND NORMOTENSIVE CONTROLS

Y. Plantinga, L. Ghiadoni, A. Magagna, S. Salvini, M. Ceroti, G. Masala, D. Palli, S. Taddei, A. Salvetti
Pages: 53 - 53
Conference Abstract

P.003 EFFECTS OF AGING ON PULSE WAVE VELOCITY IN AFRICAN MEN AND WOMEN

A.E. Schutte, H.W. Huisman, M. Reimann, J.M. Van Rooyen, L. Malan, N.T. Malan
Pages: 53 - 53
Conference Abstract

P.004 ETHNIC DIFFERENCES IN PULSE WAVE VELOCITY AND ITS RELATION TO BLOOD PRESSURE

H.W. Huisman, A.E. Schutte, J.M. Van Rooyen, M. Reimann, L. Malan, N.T. Malan, R. Schutte
Pages: 53 - 54
Research Article

Impact of leg heating on central hemodynamics in postmenopausal women

Keisei Kosaki, Jun Sugawara, Asako Zempo-Miyaki, Seiji Maeda
Pages: 53 - 57
Background: The determinants responsible for increasing central pressure augmentation, a strong risk factor for cardiovascular disease, remain highly controversial. The aim of this study was to determine the contribution of the impedance mismatch between central and leg arteries on central pressure augmentation....
Conference Abstract

3.4 RESERVOIR PRESSURE SEPARATION AT BRACHIAL, CAROTID AND RADIAL ARTERIES: A QUANTITATIVE COMPARISON AND EVALUATION

Michael Ebner, Kim Parker, Tom Vercauteren, Sébastien Ourselin, Siegfried Wassertheurer, Alun Hughes, Bernhard Hametner
Pages: 54 - 54
Background: At present, reservoir pressure parameters are derived from arterial pressure waveforms regardless of the location of measurement. However, a comparison between sites has not been made, and site-related differences may affect interpretation. In this study, we computed reservoir pressure waveform...
Conference Abstract

4.2 WITHDRAWAL OF STATINS THERAPY IN PATIENTS AFTER CAROTID ENDARTERECTOMY ASSOCIATED WITH INCREASING RISK OF SIGNIFICANT RESTENOSIS

Olga Tereshina, Alexcey Vachev
Pages: 54 - 54
Background: The benefit of carotid revascularization is decreased by the occurrence of restenosis at the site of surgery, which is associated with a modestly increased risk of stroke. Preventing restenosis plays pivotal role in the overall treatment and prevention of stroke in patients with carotid artery...
Conference Abstract

P.005 INCREASED ARTERIAL WALL STIFFNESS IN RESISTANT HYPERTENSIVE PATIENTS IN COMPARISON WITH ESSENTIAL HYPERTENSION

J. Rosa, R. Holaj, B. Strauch, O. Petrak, T. Pikus, T. Zelinka, D. Wichterle, j. Widimsky
Pages: 54 - 54
Conference Abstract

3.5 HEART RATE DEPENDENCE OF REGIONAL AND LOCAL AORTIC PULSE WAVE VELOCITY IN RATS AS A FUNCTION OF BLOOD PRESSURE

Bart Spronck, Isabella Tan, Koen Reesink, Dana Georgevsky, Tammo Delhaas, Alberto Avolio, Mark Butlin
Pages: 54 - 54
Background: Pulse wave velocity (PWV) is quantified by time difference of arrival of the blood pressure (BP) wave at two sites along the arterial bed (transit time; TT-PWV), or by combining measured arterial pressure and diameter using the Bramwell-Hill equation (BH-PWV). Besides the dependence of PWV...
Conference Abstract

4.3 ELECTRONIC CIGARETTE SMOKING INCREASES AORTIC STIFFNESS IN YOUNG SMOKERS

Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Nikolaos Ioakeimidis, Mahmud Abdelrasoul, Christos Georgakopoulos, Panagiota Pietri, Christodoulos Stefanadis, Dimitrios Tousoulis
Pages: 54 - 54
Purpose/Background/Objectives: Smoking increases aortic stiffness which is an important predictor of cardiovascular risk. Electronic cigarettes (EC) simulate tobacco cigarette (TC) and have been advocated as a less harmful alternative. We investigated the acute effect of EC smoking on aortic stiffness...
Conference Abstract

3.6 NON-INVASIVE, MRI-BASED ESTIMATION OF PATIENT-SPECIFIC AORTIC BLOOD PRESSURE USING ONE-DIMENSIONAL BLOOD FLOW MODELLING

Jorge Mariscal Harana, Arna van Engelen, Torben Schneider, Mateusz Florkow, Peter Charlton, Bram Ruijsink, Hubrecht De Bliek, Israel Valverde, Marietta Carakida, Kuberan Pushparajah, Spencer Sherwin, Rene Botnar, Jordi Alastruey
Pages: 54 - 55
Background and objectives: Clinical evidence shows that central (aortic) blood pressure (CBP) is a better marker of cardiovascular risk than brachial pressure [1]. However, CBP can only be accurately measured invasively, through catheterisation. We propose a novel approach to estimate CBP non-invasively...
Conference Abstract

4.4 ARTERIAL PHENOTYPE MODULATION AND REGULATION OF VASCULAR FIBROSIS IN MICE BY CONDITIONAL INACTIVATION OF INTEGRIN AV SUBUNIT IN VASCULAR SMOOTH MUSCLE CELLS

Ekaterina Belozertseva, Huguette Louis, Zhenlin Li, Mustapha Bourhim, Dominique Dumas, Veronique Regnault, Patrick Lacolley
Pages: 54 - 55
Integrin αv functions as a receptor for adhesion proteins and is expressed at high density in vascular smooth muscle cells (VSMC)1,2,3,4,5 whose phenotypic modulation plays a crucial role in arterial ageing and atherosclerosis.6,7. Our aim was to define the arterial phenotype in mice conditionally inactivated...
Conference Abstract

P.007 REFERENCE VALUES FOR ARTERIAL STIFFNESS IN A SUB-SAHARAN AFRICAN POPULATION

M. Reimann, H.W. Huisman, R. Schutte, L. Malan, J.M. van Rooyen, A.E. Schutte
Pages: 54 - 54
Conference Abstract

P.009 THE EFFECT OF SPIRONOLACTONE ON PULSE WAVE CHARACTERISTICS IN HYPERTENSION: INFLUENCE OF THE ALDOSTERONE TO RENIN RATIO (ARR)

K.M.S. AlHashmi, H.K. Parthasarathy, A.D. McMahon, A.D. Struthers, T.M. MacDonald, I. Ford, G.T. McInnes, J.M.C. Connell
Pages: 54 - 55
Research Article

Regional differences in the vascular response to CO2 among cerebral, ocular, and mesenteric vessels

A. Miyaji, T. Ikemura, Y. Hamada, N. Hayashi
Pages: 54 - 59
Background: It is well-known that cerebral and ocular vessels are highly sensitive to changes in the partial pressure of CO2 (PETCO2). However, it is unclear whether there are regional differences in the magnitude of the vascular response to CO2 (CO2 reactivity) in various vessels of a single individual,...
Research Article

Association between endothelial NO synthase polymorphism (rs3918226) and arterial properties

Jitka Seidlerová, Jan Filipovský, Otto Mayer, Renata Cífková, Martin Pešta, Radek Blatný, Jiří Vaněk
Pages: 54 - 59
Background: Recently, rs3918226 polymorphism in the promoter region of endothelial NO synthase (eNOS) was strongly associated with arterial hypertension in a large genome-wide association study. We investigated whether this polymorphism was associated with arterial phenotypes in a Czech general population. Methods:...
Conference Abstract

3.7 CHANGES OF INTRINSIC STIFFNESS OF THE CAROTID ARTERIAL WALL DURING THE CARDIAC CYCLE MEASURED BY SHEAR WAVE ELASTOGRAPHY IN HYPERTENSIVES COMPARED TO NORMOTENSIVES

Louise Marais, Mathieu Pernot, Hakim Khettab, Michael Tanter, Emmanuel Messas, Mustapha Zidi, Stéphane Laurent, Pierre Boutouyrie
Pages: 55 - 55
Objective: Because measurement of arterial stiffness is highly dependent on blood pressure (BP), methods independent of BP are required. Shear wave elastography (SWE, Supersonic Imagine, Aix-en-Provence, France) enables to assess local tissue stiffness by tracking the propagation of shear waves generated...
Conference Abstract

4.5 U-SHAPED RELATIONSHIP OF RESERVOIR PRESSURE TO CARDIOVASCULAR EVENTS IN PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION

Stephanie Parragh, Bernhard Hametner, Christopher Mayer, Siegfried Wassertheurer, Thomas Weber
Pages: 55 - 55
Objectives: Parameters of aortic stiffness are considered important indicators of cardiovascular risk. However, in heart failure with reduced ejection fraction (HFrEF), their association to outcome was found to be inversed. The aim of this work was to analyze the relationship of the amplitude of reservoir...
Conference Abstract

P.010 RENAL ARTERY STENOSIS AND ITS DIAGNOSTICS IN TYPE 2 DIABETIC PATIENTS

I. Klefortova, M. Shamkhalova, A. Bukhman, O. Remizov, M. Shestakova, D. Ustyuzhanin, M. Sharia, E. Tugeeva, U. Buziashvili
Pages: 55 - 55
Conference Abstract

3.8 IMPLEMENTING FLUID-STRUCTURE INTERACTION COMPUTATIONAL AND EMPIRICAL TECHNIQUES TO ASSESS HEMODYNAMICS OF ABDOMINAL AORTIC ANEURYSMS

Hannah Safi, Nathan Phillips, Yiannis Ventikos, Richard Bomphrey
Pages: 55 - 56
An Abdominal Aortic Aneurysm (AAA) represents a degenerative disease process of the abdominal aorta that leads to a focal dilation and irreversible remodeling of the arterial wall [1]. The reliable assessment of AAA rupture risk in a clinical setting is crucial in decreasing related mortality without...
Conference Abstract

4.6 BEAT-BY-BEAT ASSESSMENT OF CARDIAC AFTERLOAD USING AORTIC PU LOOP – A PILOT STUDY

Arthur Le Gall, Jona Joachim, Joaquim Mateo, Alexandre Mebazaa, Etienne Gayat, Fabrice Vallée
Pages: 55 - 56
Purpose/Background/Objectives: Cardiac afterload evaluation is crucial during general anesthesia (GA) especially during hypotension episode. Using beat to beat aortic pressure (P) / flow velocity (U) loop constructed from routine signals recorded during GA might allow to track afterload changes. Methods:...
Review Article

Wave potential: A unified model of arterial waves, reservoir phenomena and their interaction☆

Jonathan P. Mynard, Joseph J. Smolich
Pages: 55 - 63
Models of haemodynamics play a central role in current research directed to understanding and addressing cardiovascular disease. Although conventional windkessel and wave models are very useful, they are incompatible due to conflicting assumptions and neither comprehensively explain the basis and interdependencies...
Short Communication

Relationship between the aortic valves and an anatomical landmark using chest CT scan

Magid Hallab, Pascal Chevalet, Amine Dahou, Gilles Berrut
Pages: 55 - 57
Purpose: In order to determine if the height of a subject could be a reliable surrogate variable to determine the pulse wave travelling distance within the aorta, we investigated the anatomical distance between the aortic valve nidus and the hyoid bone. Methods: Using 28 patient’s chest CT-scans. From...
Conference Abstract

4.1 PILOT STUDY ON THE PRECLINICAL VASCULAR DAMAGE IN BOLIVIAN PATIENTS WITH CHAGAS INDETERMINATE CHRONIC PHASE

Filippo Valbusa, Andrea Angheben, Verena Zerbato, Andrea Chiampan, Davide Agnoletti, Cristiano Fava, Zeno Bisoffi, Guido Arcaro
Pages: 56 - 56
Background: In Italy, the prevalence of seropositivity for Trypanosoma cruzi in immigrants from endemic countries is about 11.3% (30.7% for Bolivian immigrants). The disease acute phase is usually asymptomatic, often leading to chronic infection that may remain silent for life (chronic indeterminate...
Conference Abstract

4.7 MEASUREMENT OF ARTERIAL STIFFNESS USING A CONNECTED BATHROOM SCALE: CALIBRATION AGAINST SPHYGMOCOR

Pierre Boutouyrie, Hakim Khettab, David Campo, Roger Yu, Nadine Buard
Pages: 56 - 56
Background: Measurement of arterial stiffness (AS) is still considered difficult. We developed a non-invasive technique to assess AS from a connected bathroom scale, based on ballistocardiography (BCG) and impedance plethysmography (IPG). Methods: We included 198 subjects and patients, 111 for calibration...
Conference Abstract

4.2 SEX-DEPENDENT EFFECTS OF PERIVASCULAR ADIPOSE TISSUE ON VASCULAR FUNCTION

Christian Delles, Sarah McNeilly, Sheon Mary, Adam Sheikh, Heather Small
Pages: 56 - 56
Background: Premenopausal women are relatively protected against hypertension compared to males. Estrogen levels have been identified as a potential underlying cause, but the pathophysiological mechanisms remain incompletely understood. We hypothesised that sex-dependent effects of perivascular adipose...
Conference Abstract

4.8 INCREASED CARDIAC WORKLOAD IN THE UPRIGHT POSTURE IN MALE SUBJECTS: NON-INVASIVE HEMODYNAMICS IN MEN VERSUS WOMEN

Pauliina Kangas, Anna Tahvanainen, Antti Tikkakoski, Jenni Koskela, Marko Uitto, Jari Viik, Mika Kahonen, Tiit Koobi, Emeritus Jukka Mustonen, Ilkka Porsti
Pages: 56 - 56
Background: Men and women differ in the risk of cardiovascular disease, but the underlying mechanisms are not completely understood. We examined possible sex-related differences in supine and upright cardiovascular regulation. Methods: Hemodynamics were recorded from 167 men and 167 women of matching...
Conference Abstract

4.3 ABNORMAL PRESSURE WAVE REFLECTION ACCELERATES THE DEVELOPMENT OF HYPERTENSION VIA THE INCREASE OF ARTERIAL STIFFNESS

Hirofumi Tomiyama, Akira Yamashina, Shunsuke Komatsu, Kazuki Shiina, Chisa Matsumoto, Shogen Fujii, Taishiro Chikamori
Pages: 56 - 56
Objectives: It is noted that not only arterial stiffness but also abnormal pressure wave reflection are risks for the development of hypertension. However, the association between arterial stiffness and pressure wave reflection in the development of hypertension has not been fully clarified. The present...