Artery Research

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2992 articles
Conference Abstract

P5.18 TRANSRADIAL APPROACH FOR VERTEBRAL ARTERY STENTING: SINGLE-CENTER EXPERIENCE

Damian Maciejewski*, Lukasz Tekieli, Anna Kablak-Ziembicka, Karolina Dzierwa, Piotr Paluszek, Andrzej Brzychczy, Grzegorz Lewinski, Magdalena Wojcik-Pedziwiatr, Roman Machnik, Piotr Pieniazek
Pages: 24 - 24
Objectives: Transradial vertebral artery (VA) angioplasty might be a viable alternative to the transfemoral approach in cases of peripheral artery disease or anatomical variations of the aortic arch. The purpose of our study was to evaluate the safety and efficacy of transradial stenting of symptomatic...
Conference Abstract

P5.19 TRANSRADIAL APPROACH FOR CAROTID ARTERY STENTING: SINGLE-CENTER EXPERIENCE

Damian Maciejewski*, Lukasz Tekieli, Anna Kablak-Ziembicka, Piotr Paluszek, Mariusz Trystula, Karolina Dzierwa, Magdalena Wojcik-Pedziwiatr, Roman Machnik, Grzegorz Lewinski, Piotr Pieniazek
Pages: 24 - 24
Objectives: The transfemoral approach is commonly used for carotid artery stenting (CAS) however in cases of severe peripheral vascular disease or unfavorable aortic arch anatomy, the transradial access remains a viable alternative. We report a series of patients with aorto-iliac disease or unsuccessful...
Conference Abstract

P5.20 MEASURE OF CHANGE IN CAROTID-RADIAL PULSE WAVE VELOCITY AFTER REACTIVE HYPERAEMIA

Hakim Khettab*, Benjamin Nayagom, Sandrine Millasseau, Stephane Laurent, Pierre Boutouyrie
Pages: 24 - 24
The recognized reference method for endothelial function assessment is brachial artery diameter echo-tracking during flow mediated dilation (FMD) induced by reactive hyperaemia (RH). From the Mons-Korteweg equation, FMD should also reduce upper limb pulse wave velocity (PWV). The aim of our study was...
Conference Abstract

P5.21 PERCUTANEOUS CORONARY INTERVENTIONS OF CHRONIC TOTAL OCCLUSIONS: GENDER DIFFERENCES – SINGLE CENTER EXPERIENCE

Leszek Bryniarski*, Slawomir Surowiec, Lukasz Klima, Michal Terlecki, Piotr Jankowski, Marek Rajzer, Piotr Kusak, Tadeusz Krolikowski, Adam Curylo, Dariusz Dudek, Danuta Czarnecka
Pages: 24 - 25
Background: Little is known about gender differences among patients undergoing percutaneous coronary intervention (PCI) for chronic total occlusion (CTO). Methods: A total of 242 patients underwent 255 procedures PCI of CTO in our center between January 2011 and January 2015. Demographic data, procedural...
Research Article

Numerical modeling of a prototype cardiac assist device by implementing fluid-structure interaction

Shahrokh Rahmani, Mehrnaz Oveysi, Alireza Heidari, Mahdi Navidbakhsh, Mansour Alizadeh
Pages: 24 - 35
The purpose of this study is to simulate the blood flow in a 2D axisymmetric model for the aorta assisted with a type of cardiac assist device in which the balloon part is surrounding the ascending aorta and can pump the blood flow by its inflation/deflation. The blood flow and von Mises stress in the...
Short Communication

The acute effect of maximal aerobic and isometric exercise on arterial stiffness parameters in boys and men

Elizabeth C. Schroeder, Sushant M. Ranadive, Kevin S. Heffernan, Sae Young Jae, Bo Fernhall
Pages: 24 - 28
Purpose: To evaluate whether the acute effects of aerobic or isometric exercise on arterial stiffness parameters differ between boys and men. Methods: Fourteen boys (10 ± 2 years, BMI 17.8 ± 1.9 kg/m2) and nine men (26 ± 3 years, BMI 24.4 ± 3.3 kg/m2) completed maximal aerobic and isometric exercise...
Research Article

Evaluation of losmapimod in patients with chronic obstructive pulmonary disease (COPD) with systemic inflammation stratified using fibrinogen (‘EVOLUTION’): Rationale and protocol

M. Fisk, D. Mohan, J. Cheriyan, L. Yang, J. Fuld, C.M. McEniery, R. Tal-Singer, M.I. Polkey, I.B. Wilkinson
Pages: 24 - 34
Introduction: p38 mitogen-activated protein kinases (MAPK) are key signalling molecules in cellular responses to external stresses, regulate pro-inflammatory cytokine expression and are implicated in the inflammatory pathogenesis of Chronic Obstructive Pulmonary Disease (COPD) and atherosclerosis. The...
Research Article

Comparison of estimates of central systolic blood pressure and peripheral augmentation index obtained from the Omron HEM-9000AI and SphygmoCor systems

Charlotte J. Richardson, Kaisa M. Maki-Petaja, Barry J. McDonnell, Stacey S. Hickson, Ian B. Wilkinson, Carmel M. McEniery
Pages: 24 - 31
Central blood pressure is increasingly considered to be more predictive of cardiovascular events than peripheral pressure. Central systolic pressure (cSBP) can be estimated from the late systolic shoulder (pSBP2) of the radial pulse waveform. The Omron HEM-9000AI utilizes this technique to non-invasively...
Research Article

Multiple splenic artery aneurysms in a patient with idiopathic thrombocytopenic purpura: A case report, brief literature review and discussion

David Busel, Alonso Yanez, Edgard Jimenez, Christopher K. Johansen
Pages: 24 - 26
Multiple splenic artery aneurysms in a patient with idiopathic thrombocytopenic purpura: A case report, brief literature review and discussion.
Research Article

Non-invasive ultrasound-based assessment of ventricular–arterial interaction in vascular Ehlers–Danlos syndrome patients

Koen D. Reesink, Evelien Hermeling, Kim-Thanh Ong, Martijn C.G.J. Brouwers, Robert S. Reneman, Pierre Boutouyrie, Arnold P.G. Hoeks
Pages: 24 - 29
The role of ventricular–arterial hemodynamic interaction in the occurrence of arterial dissection and rupture in vascular Ehlers–Danlos syndrome (vEDS) is unknown. We recently introduced an ultrasound-based method to extract, from common carotid artery (CCA) diameter waveforms, central arterial properties...
Conference Abstract

P6.1 DIURNAL CHANGES IN PULSE PRESSURE AMPLIFICATION IN NORMOTENSIVE, HYPERTENSIVE DIPPER AND HYPERTENSIVE NON-DIPPER PATIENTS

Sandrine Millasseau, Yulia Kotovskaya, Jirar Topouchian, Igor Posokhov*
Pages: 25 - 25
Office central blood pressure (cBP) have been shown to better predict cardiovascular events than standard peripheral pressure. With Vasotens software and BPLab monitor (OOO Petr Telegin, Russia) is now possible to estimate central pressure over 24h. However to date, no data have shown that 24h monitoring...
Conference Abstract

P6.2 AORTIC-TO-BRACHIAL STIFFNESS GRADIENT INDEPENDENTLY PREDICTS KIDNEY FUNCTION: CASE-CONTROL COMPARISON BETWEEN PATIENTS WITH TYPE 2 DIABETES AND NON-DIABETIC CONTROLS

Dean Picone*, Martin Schultz, Rachel Climie, Velandai Srikanth, James Sharman
Pages: 25 - 25
Background: A negative aortic-brachial stiffness gradient (ab-SG), whereby aortic pulse wave velocity (aPWV)≥brachial PWV (bPWV) predicts mortality independent of aPWV in dialysis patients. Patients with type 2 diabetes mellitus (T2DM) have increased risk of renal damage and exhibit haemodynamic abnormalities...
Conference Abstract

P6.3 PLATELET ACTIVITY IN TEEN GIRLS WITH PRIMARY ARTERIAL HYPERTENSION

Indre Bauziene*, Kazys Simanauskas, Virginijus Sapoka, Vytautas Kasiulevicius, Kristina Ryliskiene, Reda Matuzeviciene, Augustina Jankauskiene, Tomas Rekasius
Pages: 25 - 25
Objective: Primary arterial hypertension (PAH) – a multifactorial disease. Its etiology, especially in children, still causes a lot of questions and diagnostic tests are not common in clinical practice. Even less is known of the variation in platelet activity in adolescents with PAH, this study was the...
Conference Abstract

P6.4 PLATELET ACTIVITY IN TEENAGE BOYS WITH PRIMARY ARTERIAL HYPERTENSION

Indre Bauziene*, Kazys Simanauskas, Virginijus Sapoka, Vytautas Kasiulevicius, Reda Matuzeviciene, Kristina Ryliskiene, Augustina Jankauskiene, Tomas Rekasius
Pages: 25 - 25
Objective: Primary arterial hypertenion for teen has caused a lot of debate today, there is too much uncertainty about platelet functional changes in patients with PAH. The objective was to evaluate platelet activity in healthy and suffering from PAH groups of 17–18 year old boys. Materials and methods:...
Review Article

Recent developments in near-infrared spectroscopy (NIRS) for the assessment of local skeletal muscle microvascular function and capacity to utilise oxygen

Siana Jones, Scott T. Chiesa, Nishi Chaturvedi, Alun D. Hughes
Pages: 25 - 33
Purpose of review: Continuous wave near infrared spectroscopy (CW NIRS) provides non-invasive technology to measure relative changes in oxy- and deoxy-haemoglobin in a dynamic environment. This allows determination of local skeletal muscle O2 saturation, muscle oxygen consumption ( V˙O2 )...
Research Article

High Systolic Blood Pressure is Associated with Increased Cardio-ankle Vascular Index in the Elderly

Thapanee Roengrit, Ruchada Sri-amad, Nawiya Huipao
Pages: 25 - 31
Background: Increased arterial stiffness caused by elevated Blood Pressure (BP) can be indicated by the Cardio-ankle Vascular Index (CAVI). However, the relationship between arterial stiffness and BP is complex. In addition, changes in BP may contribute to increased risk of cardiovascular disease associated...
Conference Abstract

P6.5 EFFECTIVENESS OF FACEBOOK FOR PARTICIPANT RECRUITMENT INTO A BLOOD PRESSURE RANDOMISED CONTROLLED CLINICAL TRIAL

Erin Nash*, James Sharman
Pages: 26 - 26
Background: The cost of conventional advertising to recruit participants for clinical trials is expensive and can be ineffective. Social media may be a useful tool to improve participant recruitment. This study evaluated the use of Facebook advertising to recruit participants into a clinical trial. Methods:...
Conference Abstract

P6.6 NITROGLYCERIN IMPROVES SYSTOLIC MYOCARDIAL EFFICIENCY

Haotian Gu*, Henry Fok, Benyu Jiang, Manish Sinha, John Simpson, Phil Chowienczyk
Pages: 26 - 26
Introduction: Nitroglycerin (NTG) has a particularly marked action to reduce augmentation pressure (cAP), attributed to a reduction in timing or amplitude of pressure wave reflection. However, a recent study suggests that cAP is determined in large part by ventricular contraction/relaxation dynamics....
Conference Abstract

P6.7 DETERMINANTS FOR DIFFERENCES IN CENTRAL SYSTOLIC BLOOD PRESSURE CAUSED BY DIFFERENT CALIBRATION METHODS

Christopher Mayer, Martin Bauhofer, Bernhard Hametner, Christoph Schmaderer, Uwe Heemann, Siegfried Wassertheurer*, Marcus Baumann
Pages: 26 - 26
Introduction: There are known issues and ongoing discussions regarding calibration methods using peripheral mean and diastolic or peripheral systolic and diastolic pressure for the determination of central systolic blood pressure. The aim of this cross-sectional study is an analysis of determinants for...
Conference Abstract

P6.8 COMPARISON OF CENTRAL BLOOD PRESSURE ESTIMATED BY UPPER-ARM CUFF-BASED DEVICE WITH RADIAL TONOMETRY

Xiaoqing Peng*, Martin Schultz, Walter Abhayaratna, Michael Stowasser, James Sharman
Pages: 26 - 26
Background: New techniques that measure central blood pressure (BP) using an upper arm cuff-based approach require assessment for performance. The aim of this study was to compare a cuff-based device (CuffCBP) to estimate central BP indices [systolic BP, diastolic BP, pulse pressure (PP), augmentation...
Conference Abstract

P6.9 MEASURING ARTERIAL STIFFNESS USING POPMETRE® IN THE AFRICAN HETEROZYGOUS AND HOMOZYGOUS SICKLE CELL DISEASE

Valentine Ouédraogo, Hasan Obeid*, Magid Hallab, Isabelle Signolet, Mor Diaw, Amadou Ba, Georges Lefthériotis
Pages: 26 - 27
Aim: The sickle cell trait (SCT) is the heterozygous and benign form of the homozygous SC disease (SCD). Although SCT exhibits hemorheological disturbances and increased oxidative stress, its exact role in the development of cardiovascular disease in SCT remains to be determined. The present study sought...
Research Article

Molecular determinants of arterial stiffness

Stéphane Laurent, Céline Fassot, Patrick Lacolley, Pierre Boutouyrie
Pages: 26 - 31
Arterial stiffness has an independent predictive value for cardiovascular events. This review proposes an integrated view of the molecular determinants of arterial stiffness, based on a candidate gene approach, an analysis of the structure–function relationship in hypertension, and studies on gene expression...
Conference Abstract

P6.10 ALCOHOL INTAKE IS ASSOCIATED WITH 24-HOUR AORTIC BLOOD PRESSURE IN A YOUNG HEALTHY STUDENT COHORT

James Thomas*, Niamh Chapman, Laura Watkeys, Maria Kearney, Sue King, Eric Stohr, John Cockcroft, Margaret Munnery, Carmel McEniery, Barry McDonnell
Pages: 27 - 27
Objective: Increased brachial (bBP) and aortic blood pressure (aBP) have been linked to increased arterial stiffness and cardiovascular risk in older individuals. Literature suggests that increased alcohol intake is associated with increased BP both acutely and long term in older adults and heavy alcohol...
Conference Abstract

P6.11 THE FRAMINGHAM RISK SCORE IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Nichola Gale*, Margaret Munnery, Ali Albaratti, Dennis Shale, John Cockcroft
Pages: 27 - 27
Background: Patients with chronic obstructive pulmonary disease (COPD) have increased risk of cardiovascular (CV) events and mortality beyond that attributable to smoking. Increased arterial stiffness has been identified in COPD, however it prognostic value has not been established. The Framingham risk...
Conference Abstract

P6.12 AORTIC AND LOCAL CAROTID STIFFNESS: RELATIONSHIP WITH CARDIAC AND VASCULAR ORGAN DAMAGE IN A GENERAL POPULATION SAMPLE IN NORTHERN ITALY

Anna Paini*, Massimo Salvetti, Claudia Agabiti Rosei, Fabio Bertacchini, Giulia Maruelli, Giulia Rubagotti, Efrem Colonetti, Carlotta Donini, Elisa Casella, Enrico Agabiti Rosei, Maria Lorenza Muiesan
Pages: 27 - 27
Background: Carotid-femoral pulse wave velocity (aoPWV), the gold-standard measurement of arterial stiffness, has been found associated with cardiac and vascular organ damage. Less information is available with regard to the correlation between local carotid stiffness (CS) and cardiac and vascular preclinical...
Conference Abstract

P6.13 AMBULATORY AND OFFICE CENTRAL SYSTOLIC BLOOD PRESSURE IS MORE CLOSELY ASSOCIATED WITH LEFT VENTRICULAR MASS THAN AMBULATORY AND OFFICE PERIPHERAL SYSTOLIC BLOOD PRESSURE IN A YOUNG NORMOTENSIVE POPULATION

Maria Kearney*, James Thomas, Niamh Chapman, Laura Watkeys, Margaret Munnery, John Cockcroft, Rob Shave, Carmel McEniery, Eric Stöhr, Barry McDonnell
Pages: 27 - 28
Background: High blood pressure (BP) at a young age and increased left ventricular mass (LVM) are associated with increased risk of future cardiovascular mortality. In addition, ambulatory 24-hour central systolic BP (24cSBP) is more closely associated with LVM than either 24-hour peripheral SBP (24pSBP)...
Research Article

Pressure Dependency of Retinal Arterial Pulse Wave Velocity in the Rat

Mahdieh Rezaeian, Dana Georgevsky, S. Mojtaba Golzan, Stuart Graham, Alberto Avolio, Mark Butlin
Pages: 27 - 33
Purpose: The retinal vasculature provides unique in vivo access to the microcirculation and presents the possibility of measuring small artery (retinal) stiffness using pulse wave velocity (PWV). This study investigates whether retinal artery PWV (rPWV) has a blood pressure (BP) dependency. Methods:...
Research Article

Macro- and Micro-mechanical Properties of the Ovine Aorta: Correlation with Regional Variations in Collagen, Elastin and Glycosaminoglycan Levels

Phakakorn Panpho, Brendan Geraghty, Ya Hua Chim, Hannah A. Davies, Mark L. Field, Jillian Madine, Riaz Akhtar
Pages: 27 - 36
Aortic diseases are a significant cardiovascular health problem and occur in different ways across the vascular tree. Investigation of the mechanical properties of the aorta is important for better understanding of aortic diseases. In this study, the biomechanical and biochemical properties of the ovine...
Research Article

Effects of dietary modification with weight loss on central blood pressure during oral glucose tolerance test in overweight/obese men

Toru Yoshikawa, Hiroshi Kumagai, Kanae Myoenzono, Asako Zempo-Miyaki, Takehiko Tsujimoto, Kiyoji Tanaka, Seiji Maeda
Pages: 27 - 34
Background: Postprandial regulation of central systolic blood pressure (cSBP) is impaired by obesity-related disorders. The present study aimed to examine the effect of hypocaloric diet intervention on cSBP when performing oral glucose tolerance test (OGTT) in overweight/obese men and explore its mechanism. Methods:...
Review Article

Combination therapy in hypertension: From effect on arterial stiffness and central haemodynamics to cardiovascular benefits☆

Charalambos Vlachopoulos
Pages: 27 - 35
Measures of arterial aging have the potential to improve risk prediction beyond traditional risk scores. Such biomarkers that fulfil most, or some of the strict criteria of a surrogate end-point are aortic stiffness (IIa level of recommendation in European Guidelines and Position Papers) and central...
Research Article

Aortic root calcification and cardiac risk factors in patients with coronary calcium score greater than zero using multidetector computed tomography

Hasan A. Al-Nafakh, Hussein Nafakhi, Mohammed Abd Kadhim Al-Jiboori, Abdulameer A. Al-Mosawi, Raad H. Tawfeq
Pages: 27 - 31
Background: Vascular calcification is a marker of atherosclerotic burden and is associated with increased risk of cardiac events. The aim of this study was to investigate the relationship between clinical cardiac risk factors and aortic root calcification (ARC) in patients with a coronary calcium score...
Research Article

Impact of obesity on aortic root calcification and coronary calcification using multi-detector CT

Hussein Nafakhi, Hasan A. Al-Nafakh, Abdulameer A. Al-Mosawi
Pages: 27 - 32
Objective: The impact of obesity measured by BMI on cardiovascular diseases remains controversial. We investigated the impact of obesity measured by BMI on the prevalence and correlation of aortic root calcification (ARC) and coronary artery calcification (CAC) in patients assessed by multi-detector...
Research Article

Carotid–femoral pulse wave velocity: Impact of different arterial path length measurements

Jun Sugawara, Koichiro Hayashi, Takashi Yokoi, Hirofumi Tanaka
Pages: 27 - 31
Background: Carotid–femoral pulse wave velocity (PWV) is the most established index of arterial stiffness. Yet there is no consensus on the methodology in regard to the arterial path length measurements conducted on the body surface. Currently, it is not known to what extent the differences in the arterial...
Conference Abstract

P6.14 THE EFFECT OF PHYSICAL ACTIVITY ON 24-HOUR AUGMENTATION INDEX

Niamh Chapman*, James Thomas, Maria Kearney, Laura Watkeys, Margaret Munnery, John R. Cockcroft, Carmel M. McEniery, Eric J. Stohr, Barry J. McDonnell
Pages: 28 - 28
Introduction: Augmentation Index (AIx) is a surrogate measure of systemic arterial stiffness and wave reflections. Clinic measures of AIx are considered to be a sensitive measure of risk in young adults and are lower in individuals who take part in high levels of physical activity (PA). The development...
Conference Abstract

P6.15 ATTENUATION OF ARTERIAL STIFFNESS GRADIENT WITH AGE AND ITS IMPACT ON CENTRAL PULSE WAVE PROFILE IN DIALYSIS PATIENTS

Catherine Fortier, Marie-Pier Desjardins, David Turgeon, Karine Marquis, Marcel Lebel, Mohsen Agharazii*
Pages: 28 - 28
Background: Arterial stiffness has been considered as an index of vascular ageing. However, the relationship between age and stiffness of various segments of the arterial tree is heterogeneous. Moreover, the hemodynamic impact of vascular stiffness is thought to be related to the attenuation or even...
Conference Abstract

P6.16 LEFT VENTRICULAR GEOMETRY AND CAROTID VASCULAR DAMAGE IN PATIENTS UNDERGOING CORONARY ANGIOGRAPHY

M. Salvetti*, A. Paini, M.F. Cesana, A. Moreo, R. Facchetti, P. Faggiano, S. Carerj, G.F. Mureddu, N. Gaibazzi, F. Rigo, C. Giannattasio, M.L. Muiesan
Pages: 28 - 28
Background: Vascular structural(intima-media thickness, IMT) and functional(carotid stiffness, cPWV)alterations are related to different pattern of left ventricular (LV) geometry in general populations and in hypertensives. The relationship between vascular damage and LV geometry has not been analyzed...
Conference Abstract

P6.17 CARDIOVASCULAR RISK FACTORS CONTRIBUTE TO THE VARIANCE OF WALL-TO-LUMEN RATIO

Rytis Masiliunas*, Kristina Ryliskiene, Ligita Ryliskyte, Rokas Navickas, Jurgita Kuzmickiene, Jolita Badariene, Dalius Jatuzis, Aleksandras Laucevicius
Pages: 28 - 29
Background: Common carotid artery intima-media thickness (cIMT) is an accepted ultrasound marker of subclinical atherosclerosis. It is argued that increase in cIMT may also reflect nonatherosclerotic thickening, thus, lumen diameter could be taken into account. A common approach to account for lumen...
Short Communication

Does the acute hemodynamic response to a maximum running exercise depend on the aerobic training status of the subjects?

Fabian Tomschi, Hannah Ottmann, Joachim Latsch, Hans-Georg Predel, Wilhelm Bloch, Marijke Grau
Pages: 28 - 31
Background: High-intensity training has become increasingly popular in recent years but the exact effects of high intensity running on the hemodynamic system are not entirely understood and it is unknown whether the aerobic training status of the subjects might influence these hemodynamic reactions....
Review Article

MicroRNAs associated with the pathways involved in the pathogenesis of abdominal aortic aneurysms

P.W. Stather, J.B. Wild, N. Sylvius, E. Choke, R.D. Sayers, M.J. Bown
Pages: 28 - 35
Objectives: MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at a post-transcriptional level. Through binding to mRNA sequences, miRNAs have a wide variety of functions, and are key regulators in vascular disease. Although there are only 2 papers looking directly at the association...
Research Article

Central and peripheral pulse wave velocities are associated with ankle–brachial pressure index

Valérie Lacroix, Marie Willemet, Robert Verhelst, Christophe Beauloye, Luc Jacquet, Parla Astarci, Alexandre Persu, Emilie Marchandise
Pages: 28 - 33
Background: Central Pulse Wave Velocity (PWV) is considered to be the gold standard measurement of arterial stiffness. In healthy subjects, cardiovascular risk factors such as age, hypertension, diabetes and end-stage renal disease are associated with increased central (Carotid–Femoral) and peripheral...
Conference Abstract

P6.18 CARDIOVASCULAR TARGET ORGAN DAMAGE IN PREMENOPAUSAL SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS AND IN CONTROLS; ARE THERE ANY DIFFERENCES?

A. Paini*, L. Andreoli, M. Salvetti, F. Dall’Ara, S. Piantoni, C. Donini, C. Agabiti Rosei, F. Bertacchini, D. Stassaldi, E. Agabiti Rosei, A. Tincani, M.L. Muiesan
Pages: 29 - 29
Background: In patients with Systemic lupus erythematosus (SLE) a greater prevalence of structural and functional cardiovascular (CV) alterations has been described, possibly explaining the higher incidence of CV events, as compared to subjects matched for age and sex. Aim of this study was to analyze...
Conference Abstract

P6.19 GENDER DIFFERENCES OF ARTERIAL STIFFNESS AND CENTRAL BLOOD PRESSURE IN PATIENTS WITH ARTERIAL HYPERTENSION AND THE INFLUENCE OF MENOPAUSE

Valéria Costa-Hong, Henrique Muela, Allan Sales, Luiz Bortolotto*
Pages: 29 - 29
Introduction: In general population women seems to have greater arterial stiffness and central blood pressure(BP), measured by augmentation index (AIx), than men, but in hypertension this condition is poorly studied. Objectives: To evaluate differences of central BP and arterial stiffness between men...
Conference Abstract

P6.20 ROLE OF ALTERED VASCULAR REACTIVITY IN THE PATHOPHYSIOLOGY OF ACUTE MOUNTAIN SICKNESS

Rosa Maria Bruno*, Guido Giardini, Sandro Malacrida, Bruna Catuzzo, Sabina Armenia, Lorenzo Ghiadoni, Raffaele Brustia, Paolo Laveder, Paolo Salvi, Emmanuel Cauchy, Lorenza Pratali
Pages: 29 - 29
Purpose: The aim of this study is to explore the physiological vascular adaptation to exposure to high altitude and to test the hypothesis that its impairment might play a role in the pathophysiology of acute mountain sickness (AMS). Methods: 34 healthy volunteers (age 38±11years, 13 women) were studied...
Conference Abstract

P7.1 INCREASED PLATELET REACTIVITY IS RESPONSIBLE OF MODIFICATIONS OF THROMBIN GENERATION IN PATIENTS WITH UNCONTROLLED ARTERIAL HYPERTENSION

Jeremy Lagrange*, Yvonne Weihert, Susanne Karbach, Philip Wenzel
Pages: 29 - 30
Background: Hypertensive crisis is an extreme phenotype of increased blood pressure that can lead to organs failure and thrombotic complications. Recently, we were able to show an angiotensin II driven FXI-thrombin amplification loop leading to vascular injury in experimental hypertension. Objective:...
Research Article

Flow-mediated slowing of brachial-radial pulse wave velocity: Methodological aspects and clinical determinants

Nicholas Cauwenberghs, Yenthel Heyrman, Lutgarde Thijs, Wen-Yi Yang, Fang-Fei Wei, Zhen-Yu Zhang, Jan A. Staessen, Tatiana Kuznetsova
Pages: 29 - 37
Background: Recent studies proposed that deceleration in pulse wave velocity (PWV) following reactive hyperaemia might reflect arterial distensibility and endothelial function. We therefore investigated methodological aspects and clinical determinants of new indexes of flow-mediated slowing (FMS) of...
Research Article

Interaction studies on catecholamines to cellular receptors using in silico approach

S. Kalaivannan, T. Vinoth kambali, S. Prabhu, S. Visvanathan, N. Karpagam
Pages: 29 - 37
Catecholamines are organic compounds derived from amino acids tyrosine and phenylalanine, which acts as neurotransmitters and also functions as hormones in the blood circulation. They bind to plasma proteins and circulate in the blood stream. High levels of catecholamines will cause increase in the heart...
Research Article

Estimation of maximal oxygen consumption and heart rate recovery using the Tecumseh sub-maximal step test and their relationship to cardiovascular risk factors

Alun D. Hughes, Nish Chaturvedi
Pages: 29 - 35
Background: Maximum aerobic capacity (VO2max) is associated with lower cardiovascular and total mortality. Step tests can be used to provide an estimate of (VO2max) in epidemiological or home-based studies. We compared different methods of estimation of VO2max and heart rate recovery and evaluated the...
Conference Abstract

P7.2 VERY EARLY CLINICAL VASCULAR AND HEART MARKERS OF NEWLY RECOGNIZED HYPERTENSION IN MIDDLE AGE ADULTS

Olga Siga*, Jarosαaw Królczyk, Anna Dzieża-Grudnik, Jolanta Walczewska, Barbara Wizner, Tomasz Grodzicki
Pages: 30 - 30
The aim of this study was to evaluate vascular and echocardiographic markers of hypertension (HT) in subjects with newly diagnosed HT before treatment started. We studied 32 patients with newly diagnosed HT without pharmacological therapy (HT group) and 31 healthy ones (control group). ABPM were performed...
Conference Abstract

P7.3 RISK FACTORS CONTROL IN ELDERLY PATIENTS WITH PERIPHERAL ARTERY DISEASE

Barbara Gryglewska*, Dorota Studzinska
Pages: 30 - 30
Objective: The assessment of control of modifiable risk factors among elderly patients with peripheral artery disease (PAD) admitted to the hospital angiology ward. Methods: The results of treatment of dyslipidemia (DL), hypertension (HT), diabetes mellitus (DM) and prevalence of cigarette smoking were...
Conference Abstract

P7.4 MORNING CENTRAL BLOOD PRESSURE SURGE DOES NOT DIFFER BETWEEN MEN AND WOMEN

Agnieszka Bednarek*, Piotr Jankowski, Agnieszka Olszanecka, Adam Windak, Kalina Kawecka-Jaszcz, Danuta Czarnecka
Pages: 30 - 31
Objective: Morning blood pressure (BP) surge is considered to be an independent risk factor for cardiovascular diseases. On the other hand, there is increasing evidence that central systolic pressure (CSP) is stronger correlated with target organ damage and cardiovascular events than peripheral systolic...
Research Article

Shock index for outcome and risk stratification in acute pulmonary embolism✩

Karsten Keller, Meike Coldewey, Martin Geyer, Johannes Beule, Jörn Oliver Balzer, Wolfgang Dippold
Pages: 30 - 35
Introduction: Risk stratification of patients with acute pulmonary embolism (PE) is crucial in deciding appropriate therapy management. Shock index (SI) is rapidly available and a reliable parameter. We aimed to investigate SI for short term outcome in acute PE. Materials and methods: Data of 182 patients...
Research Article

Aortic calcification, arterial stiffness and bone mineral density in patients with COPD☆

Charlotte E. Bolton, Carmel M. McEniery, Vimal Raj, Barry J. McDonnell, Adrian K. Dixon, Margaret Munnery, Ramsey Sabit, Nicholas Screaton, Michael Stone, Ian B. Wilkinson, Dennis J. Shale, John R. Cockcroft
Pages: 30 - 36
Background: Increased arterial stiffness, using aortic pulse wave velocity (PWV) has been demonstrated in patients with COPD. However, mechanisms underlying this remain unclear. We explored the contribution of aortic calcification to large artery haemodynamics and its association to bone mineral density...
Conference Abstract

P7.5 RELATIONSHIPS BETWEEN 24 HOUR URINARY CORTISOL METABOLITES AND STRUCTURAL CARDIAC AND ARTERIAL INDICES IN PEOPLE WITH OR AT RISK OF TYPE 2 DIABETES

Charlotte Mills*, Luca Faconti, Hannah Crickmore, Fahad Iqbal, Anne Risser, Doina Bobeica, Lea Ghataore, Virginia Govoni, Maria-Linda Casagrande, Andrew Webb, Norman Taylor, Kennedy Cruickshank
Pages: 31 - 31
Objective: To assess if 24h urinary cortisol metabolite (UCM) profiles are related to structural cardiac and arterial parameters in those with or at risk of Type 2 diabetes mellitus (T2DM). Design and method: 32 participants, 25-77 years, eGFR> 45 mL/min and no serious illness. Urine was collected...
Conference Abstract

P7.7 TESTOSTERONE LEVELS IN HYPERTENSIVE PATIENTS WITH VASCULAR ORGAN DAMAGE

Dimitrios Terentes-Printzios*, Charalambos Vlachopoulos, Nikolaos Ioakeimidis, Athanassios Angelis, Panagiota Pietri, Mahmoud Abdelrasoul, Christos Georgakopoulos, Dimitris Tousoulis
Pages: 31 - 31
Purpose: Testosterone levels are decreased in hypertensive patients compared to normotensive subjects with similar age. Measurements of carotid IMT or aortic stiffness are reasonable for detecting vascular organ damage (OD) in patients with arterial hypertension. We investigated whether low testosterone...
Conference Abstract

P7.8 THE RELATIONSHIP BETWEEN RENAL AND CEREBRAL BLOOD FLOW PULSATILITY

Laura Watkeys*, James Pearson, Barry McDonnell
Pages: 31 - 31
Introduction: Increased pulsatile flow has been implicated in the progression of microvascular damage. The pulsatile blood flow transmitted into both the brain and kidney are often assumed to be similar, however specific studies confirming these associations are lacking. Therefore, the aim of this study...
Conference Abstract

P7.10 MULTI-SITE ULTRASOUND ASSESSMENT OF ARTERIAL REMODELING AND DISTENSIBILITY IN MARATHON RUNNERS

Rosa Maria Bruno*, Elisabetta Bianchini, Nicole Di Lascio, Francesco Stea, Kristian Ujka, Alberto Marabotti, Erik Stroeken, Lorenzo Ghiadoni, Lorenza Pratali
Pages: 32 - 32
Objective: to investigate features of arterial remodeling and distensibility in marathon runners by a multi-site, non-invasive approach. Methods: 46 marathon runners (M) and 15 age-sex- and BMI matched sedentary (S) individuals were recruited (men 70 vs 67%, p=0.83; age 44±7 vs 43±6 years, p=0.62; BMI...
Conference Abstract

P7.11 PREDICTIVE VALUE OF ENDOTHEL DYSFUNCTION ASSESSED BY FLOW MEDIATED VASODILATATION AND ARTERIAL STIFFNESS PARAMETERES IN THROMBOTIC EVENTS OF PRIMARY ANTIPHOSPHOLIPID SYNDROME

Agnes Dioszegi*, Katalin Veres, Beata Kovacs, Viktor Banhegyi, Pal Soltesz
Pages: 32 - 32
Primary antiphosphplipid sydrome (APS) is characterized by recurrent arterial or venous thrombosis and/or fetal loss in the presence of antiphospholipd antibodies. The authors in a longitudinal (2005–2015) follow-up study examined how the angiological and metabolic parameters have changed during the...
Conference Abstract

P7.12 PULSE PRESSURE AND INTIMA MEDIA THICKNESS IN RELATION TO SERUM VITAMIN D CONCENTRATION IN A SAMPLE OF GENERAL POPULATION

Agata Franczyk*, Katarzyna Stolarz-Skrzypek, Agnieszka Olszanecka, Wiktoria Wojciechowska, Anna Wesoαowska, Kalina Kawecka-Jaszcz, Danuta Czarnecka
Pages: 32 - 32
Objectives: Vitamin D regulates the renin-angiotensin-aldosterone system, inhibits proliferation of cardiomyocytes and vascular smooth muscles and has anti-inflammatory effects. We aimed to investigate the relation between serum vitamin D concentration and arterial structure and function in a sample...
Conference Abstract

P7.13 RELATION OF PARAMETERS OF VASCULAR STIFFNESS TO CARDIAC STRUCTURE AND FUNCTION IN PATIENTS AT RISK OF OR WITH TYPE 2 DIABETES

Luca Faconti*, Charlotte E. Mills, Virginia Govoni, Maria L. Casagrande, Andrew J. Webb, Kennedy J. Cruickshank
Pages: 32 - 33
Objective: To investigate the relationship between arterial function and cardiac, especially left ventricular (LV) diastolic, function, in people at risk of or with type 2 diabetes (T2DM). Design and method: 64 patients (48% non-European) participated in the study. Cardiac indices were obtained by 2-dimensional...
Research Article

Validation of a new piezo-electronic device for non-invasive measurement of arterial pulse wave velocity according to the artery society guidelines

Margarita S. Morales, Paula E. Cuffaro, Jessica Barochiner, Marcelo A. Rada, Jose Alfie, Lucas Aparicio, Marcos Marin, Carlos R. Galarza, Gabriel D. Waisman
Pages: 32 - 37
Our aim was to validate a new device for pulse wave velocity (PWV) measurement – Aortic according to the recommendations of the Artery Society and using SphygmoCor as the comparator device. Methods: 85 subjects 18–80 years-old from both sexes were included, divided into 3 age-groups: <30, 30–60 and...
Research Article

Association of serum paraoxonase activity with lipid profile, APO-A and APO-B in subjects with different levels of HDL

Maryam Teimouri, Hashem Nayeri
Pages: 32 - 39
Background: Coronary heart diseases are inversely related to plasma high-density lipoprotein (HDL) level. Paraoxonase-1 (PON1) is mainly associated with HDL and plays a vital role in protection of low-density lipoprotein (LDL) and HDL. The aim of this study was to investigate the association between...
Research Article

Validity and reliability of carotid-toe pulse wave velocity as a measure of arterial stiffness in healthy individuals: Comparison to carotid-femoral pulse wave velocity

Stephen A. Klassen, Kylie S. Dempster, Daniele Chirico, Deborah D. O’Leary
Pages: 32 - 38
Purpose: The present investigation evaluated the validity and reliability of carotid-toe PWV (ctPWV) as a non-intrusive measure of systemic arterial stiffness in healthy young adults. Methods: The Validity Trial examined the association and agreement between cfPWV and ctPWV in 33 adults (24 ± 2 years;...
Research Article

Inflammation and arterial function

Konstantinos A. Aznaouridis, Christodoulos I Stefanadis
Pages: 32 - 38
During the last decade, several studies have documented the unfavourable effects of inflammation on cardiovascular function and its role in the pathophysiology of atherosclerotic disease. The interplay between inflammation and arterial system is multifaceted. On the one hand, the endothelium contributes...
Research Article

Low wall shear stress predicts subsequent development of wall hypertrophy in lower limb bypass grafts

Mark Jackson, Nigel B. Wood, Shunzhi Zhao, Alexander Augst, John H. Wolfe, Wladyslaw M.W. Gedroyc, Alun D. Hughes, Simon A.McG. Thom, Xiao Y. Xu
Pages: 32 - 38
Background: Venous grafts commonly develop myointimal hyperplasia, which can lead to stenoses and, ultimately, with expression of adhesion molecules, lumenal occlusion. The aim of the present study was to investigate whether wall shear stress measured post-operatively would predict subsequent myointimal...
Research Article

The Association between Homocysteine, Arterial Stiffness and Executive Function Middle-age and Older Women

Ai Shindo-Hamasaki, Nobuhiko Akazawa, Reiko Momma, Seiji Maeda
Pages: 32 - 37
Age-related decreases in executive function and an increase in arterial stiffness and plasma homocysteine levels are related to the risk of dementia. However, the association between executive function, arterial stiffness, and homocysteine levels remains unclear. This study aimed to investigate the relationship...
Conference Abstract

P7.14 SERUM INFLAMMATORY MARKERS ARE POOR PREDICTORS OF VASCULAR INFLAMMATION AND VASCULAR INFLAMMATION DOES NOT DETERMINE AORTIC STIFFNESS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

Marie Fisk*, Divya Mohan, Joseph Cheriyan, Julia Forman, Carmel M. McEniery, John R. Cockcroft, Ruth Tal-Singer, Michael I. Polkey, Ian B. Wilkinson
Pages: 33 - 33
Background: COPD is independently associated with increased cardiovascular events. Arterial stiffening and systemic inflammation are postulated aetiological factors. We hypothesised that vascular inflammation links systemic inflammation with vascular stiffening and sought to test this in a cohort of...
Conference Abstract

P7.15 REACTIVE HYPEREMIA INDEX AND FLOW MEDIATED DILATION WITH UPPER- AND LOWER-ARM CUFF OCCLUSION: ARE THEY MEASURING THE SAME?

Lorenzo Ghiadoni*, Rosa Maria Bruno, Francesco Regoli, Giuseppe Penno, Stefano Taddei
Pages: 33 - 33
Objective: Methodological issues are major reasons preventing the use of endothelial function testing in clinical practice This study aimed to address the relationship between two non-invasive techniques, brachial artery flow-mediated dilation (FMD) and as reactive hyperemia index (RHI), comparing also...
Conference Abstract

P7.16 VALIDATION OF AN OSCILLOMETRIC BRACHIAL CUFF METHOD TO DERIVE CENTRAL BLOOD PRESSURE USING DIFFERENT CALIBRATION MODES

Martin Schultz*, Ahmad Qasem, Xiaoqing Peng, Dean Picone, J. Andrew Black, Nathan Dwyer, Phillip Roberts-Thomson, James Sharman
Pages: 33 - 33
Background: There is interest in measuring central blood pressure (BP) from non-invasive upper-arm cuff devices, the accuracy of which may be influenced by different calibration modes. The aim of this study was to determine the validity of an upper-arm cuff oscillometric device to estimate central BP...
Conference Abstract

P7.17 DISASSOCIATION OF BLOOD PRESSURE FROM AORTIC RESERVOIR CHARACTERISTICS BETWEEN THE AORTA AND RADIAL ARTERIES

Xiaoqing Peng*, Martin Schultz, Justin Davies, Dean Picone, Andrew Black, Nathan Dwyer, Phil Roberts-Thomson, James Sharman
Pages: 33 - 34
Background: Aortic reservoir pressure (RP) and excess pressure (XSP) predict cardiovascular events independent of clinic blood pressure (BP). It is unknown whether RP and XSP change in magnitude from the central to peripheral large arteries where conventional BP is measured. This information has implications...
Research Article

Effect of Benson relaxation technique on the preoperative anxiety and hemodynamic status: A single blind randomized clinical trial

Jalal Poorolajal, Fatemeh Ashtarani, Neda Alimohammadi
Pages: 33 - 38
Background: Preoperative anxiety is a challenge in most surgical interventions that needs to be taken into consideration. This trial assessed the effect of relation technique on the anxiety and hemodynamic response in patients undergoing surgical procedures. Methods: This single blind, randomized clinical...
Research Article

Clinical utility of digital volume pulse analysis in prediction of cardiovascular risk and the presence of angiographic coronary artery disease

Konstantinos Vakalis, Aris Bechlioulis, Katerina K. Naka, Konstantinos Pappas, Christos S. Katsouras, Lampros K. Michalis
Pages: 33 - 39
Background: Stiffness Index (SI), assessed by finger photoplethysmography (digital volume pulse analysis), has been suggested as a simple and easy measure of arterial stiffness. However, its potential association with cardiovascular risk and coronary artery disease (CAD) has been little studied. The...
Conference Abstract

P7.18 VALIDATION TESTING FOR THE NON-INVASIVE MEASUREMENT OF AORTIC RESERVOIR CHARACTERISTICS FROM BRACHIAL CUFF OSCILLOMERIC PRESSURE WAVEFORMS

Xiaoqing Peng*, Martin Schultz, Justin Davies, Dean Picone, Andrew Black, Nathan Dwyer, Phil Roberts-Thomson, James Sharman
Pages: 34 - 34
Background: Aortic reservoir pressure (RP) and excess pressure (XSP) derived non-invasively from radial tonometry independently predict cardiovascular events and mortality. However, whether RP and XSP can be derived non-invasively from brachial oscillometric cuff pressure waveforms has never been undertaken....
Conference Abstract

P7.19 ARTERIAL STIFFNESS AND DISEASE-RELATED ORGAN DAMAGE IN SYSTEMIC LUPUS ERYTHEMATOSUS

Giacomo Pucci*, Francesca Battista, Elena Bartoloni Bocci, Fabio Anastasio, Mariano Crapa, Leandro Sanesi, Roberto Gerli, Giuseppe Schillaci
Pages: 34 - 34
Hypothesis: increased arterial stiffness has been reported in subjects with systemic lupus erythematosus (SLE) compared with healthy controls. In SLE, indexes of organ damage are related to a poor clinical status and worse prognosis independently from the activity of the disease. Data are controversial...
Conference Abstract

P7.20 THE IMPACT OF OBSTRUCTIVE SLEEP APNEA ON ARTERIAL STIFFNESS IS INDEPENDENT OF GENDER IN PATIENTS WITH HYPERTENSION

Raimundo Jenner, Luiz Bortolotto*, Valéria Costa-Hong, Silvia Souza, Sandra Teixeira, Heno Lopes, Geraldo Lorenzi, Eduardo Krieger, Luciano Drager
Pages: 34 - 34
Introduction: In men with hypertension, obstructive sleep apnea (OSA) is associated with increased arterial stiffness. However, it is not clear if the impact of OSA on patients with hypertension is similar in women. Methods: We recruited consecutive patients with established diagnosis of hypertension...
Conference Abstract

P8.1 CENTRAL HEMODYNAMICS IN SYSTEMIC SCLEROSIS: A CASE-CONTROL STUDY

Francesca Battista*, Giacomo Pucci, Elena Bartoloni Bocci, Francesca Cannarile, Alessia Alunno, Fabio Anastasio, Roberto Gerli, Giuseppe Schillaci
Pages: 34 - 34
Background: Although a few studies have suggested an alteration in aortic stiffness in patients with systemic sclerosis (SS), a disease characterized by immunological and microvascular changes and by tissue fibrosis, the functional properties of the large arteries have been understudied in SS. Methods:...
Research Article

Relationship between Obesity Phenotypes and Cardiovascular Risk in a Chinese Cohort

Yueliang Hu, Shuping Zheng, Jiehui Zhao, Isabella Tan, Mark Butlin, Alberto Avolio, Junli Zuo
Pages: 34 - 41
Objective: The changing living patterns in China are accompanied by an increase in prevalence of cardiovascular disease for which obesity is a significant factor. This study investigated the association between obesity phenotypes and risk of cardiovascular disease in a Chinese cohort. Methods: A sample...
Research Article

Antiretroviral treatment and time since HIV-1 diagnosis are associated with large artery stiffness in sub-Saharan African HIV-1 patients

Titus F. Msoka, Gary P. Van Guilder, Yvo M. Smulders, Marceline van Furth, John A. Bartlett, Michiel A. van Agtmael
Pages: 34 - 41
Background: HIV-1 infection in northern populations is associated with increased large artery stiffness, both in the absence and presence of combination antiretroviral treatment (cART). It is unclear if similar changes occur in sub-Sahara African HIV-infected persons. The study aimed to determine whether...
Research Article

Differences in pulse pressure day variability between the brachial artery and the aorta in healthy subjects

Athanase D. Protogerou, Theodore G. Papaioannou, Petros P. Sfikakis, Jacques Blacher, Emmanouil Karatzis, John P. Lekakis, Dimitris Papadogiannis, Christodoulos Stefanadis, Michel E. Safar
Pages: 34 - 40
Objectives: To search for: (i) potential differences in the within-subject pulse pressure (PP) day time variability between the brachial artery and aorta; (ii) the presence of substantial day time variation in the aortic-to-brachial (AtB) PP disparity. Background: Brachial blood pressure (BP) variability...
Guidelines

ARTERY Society guidelines for validation of non-invasive haemodynamic measurement devices: Part 1, arterial pulse wave velocity

Ian B. Wilkinson, Carmel M. McEniery, Giuseppe Schillaci, Pierre Boutouyrie, Patrick Segers, Anne Donald, Philip J. Chowienczyk,
Pages: 34 - 40
The last 15 years have seen an explosion of interest in large artery haemodynamics, and arterial stiffness in particular. A number of devices are now available to assess arterial stiffness, and although many are in routine use, they do not necessarily provide identical information. The aim of this statement...
Conference Abstract

P8.2 ARTERIAL WAVE REFLECTIONS: LOOKING BEYOND THE FIRST HARMONIC AND PRESSURE INFLECTION POINTS TO ASSESS LATE-SYSTOLIC VENTRICULAR LOADING

Timothy Phan*, John Li, Zoubair Ahmed, Ejaz Shah, Vandan Panchal, Julio Chirinos
Pages: 35 - 35
Background: Late-systolic ventricular loading is associated with impaired relaxation and adverse remodeling. Standard indices of relative wave reflections such as augmentation index (AIx) and reflection magnitude (RM) from wave separation analysis blend different times within the cardiac cycle and are...
Conference Abstract

P8.3 RELATIONSHIP BETWEEN PULSE WAVE VELOCITY AND BIOPSY PROVEN RENAL MICROVASCULAR LESIONS

Rania Kheder-Elfekih*, Hela Jebali, Lamia Rais, Fatma Ben Moussa, Karim Zouaghi
Pages: 35 - 35
Aortic stiffness is associated to chronic kidney disease. Although it is well established that patients with chronic kidney disease have classical and non classical risk factors correlated to a high pulse wave velocity, there is no data on the deleterious effect of high pulse wave velocity on intra renal...
Conference Abstract

P8.5 MORNING CENTRAL BLOOD PRESSURE SURGE IS RELATED TO AGE

Agnieszka Bednarek*, Piotr Jankowski, Agnieszka Olszanecka, Adam Windak, Kalina Kawecka-Jaszcz, Danuta Czarnecka
Pages: 35 - 35
Objective: Morning surge of peripheral blood pressure (BP) is considered to be an independent risk factor for cardiovascular diseases. However, morning central blood pressure surge (MCBPS) has not been analyzed so far. Therefore, the aim of study was to evaluate the variables independently associated...
Conference Abstract

P8.6 PULSATILE COMPONENT OF CENTRAL BLOOD PRESSURE AND THE RISK OF STROKE IN CORONARY PATIENTS. RESULTS FROM THE AORTIC BLOOD PRESSURE AND SURVIVAL STUDY

Piotr Jankowski*, Agnieszka Bednarek, Malgorzata Kloch-Badelek, Magdalena Loster, Leszek Bryniarski, Kalina Kawecka-Jaszcz, Danuta Czarnecka
Pages: 35 - 35
Background: There is ongoing debate concerning the best blood pressure (BP) parameter predicting cardiovascular risk. The aim of the analysis was to investigate the relationship between central BP and stroke in patients undergoing coronary angiography. Methods: The study group consisted of 954 patients...
Conference Abstract

P8.7 VASCULAR ENDOTHELIAL SENESCENCE AND METABOLIC SYNDROME

Dimitrios Terentes-Printzios*, Charalambos Vachopoulos, Nikolaos Ioakeimidis, Athanasios Aggelis, Panagiotis Xaplanteris, Panagiota Pietri, Dimitrios Tousoulis
Pages: 35 - 36
Objectives: Vascular aging and metabolic syndrome (MS) are both independent predictors of cardiovascular events. We examined whether MS accelerates the progression of vascular aging. Methods: 142 subjects (mean age 51.9±10.8 years, 94 men) with no established cardiovascular disease were investigated...
Guidelines

Validation of non-invasive central blood pressure devices: Artery society task force (abridged) consensus statement on protocol standardization

James E. Sharman, Alberto P. Avolio, Johannes Baulmann, Athanase Benetos, Jacques Blacher, C. Leigh Blizzard, Pierre Boutouyrie, Chen-Huan Chen, Phil Chowienczyk, John R. Cockcroft, J. Kennedy Cruickshank, Isabel Ferreira, Lorenzo Ghiadoni, Alun Hughes, Piotr Jankowski, Stephane Laurent, Barry J. McDonnell, Carmel McEniery, Sandrine C. Millasseau, Theodoros G. Papaioannou, Gianfranco Parati, Jeong Bae Park, Athanase D. Protogerou, Mary J. Roman, Giuseppe Schillaci, Patrick Segers, George S. Stergiou, Hirofumi Tomiyama, Raymond R. Townsend, Luc M. Van Bortel, Jiguang Wang, Siegfried Wassertheurer, Thomas Weber, Ian B. Wilkinson, Charalambos Vlachopoulos
Pages: 35 - 43
Brachial cuff blood pressure (BP) is clinically important, but may be an inaccurate substitute for central BP. Many non-invasive devices have been developed that purport to estimate central BP from peripheral artery sites, yet with no standardized guidelines; the accuracy testing of these new devices...
Research Article

Central vs. peripheral blood pressure components as determinants of retinal microvessel diameters

Yu-Mei Gu, Yan-Ping Liu, Lutgarde Thijs, Tatiana Kuznetsova, Fang-Fei Wei, Harry A.J. Struijker-Boudier, Peter Verhamme, Jan A. Staessen
Pages: 35 - 43
Background: We assessed association of retinal arteriolar and venular diameters with central and peripheral blood pressure (BP). Methods: We post-processed retinal photographs from 514 participants randomly recruited from a Flemish population (mean age, 50.6 years; 50.8% women), using IVAN software...
Research Article

Vascular health and cognitive function in older adults with cardiovascular disease

Daniel E. Forman, Ronald A. Cohen, Karin F. Hoth, Andreana P. Haley, Athena Poppas, David J. Moser, John Gunstad, Robert H. Paul, Angela L. Jefferson, David F. Tate, Makoto Ono, Nicole Wake, Marie Gerhard-Herman
Pages: 35 - 43
Background: We hypothesized that changes in vascular flow dynamics resulting from age and cardiovascular disease (CVD) would correlate to neurocognitive capacities, even in adults screened to exclude dementia and neurological disease. We studied endothelial-dependent as well as endothelial-independent...
Conference Abstract

P8.8 CENTRAL ARTERIAL STIFFNESS IN COPD

Ali Albarrati*, Nichola Gale, Maggie Munnery, Sujoy Saikia, Dennis Shale, John Cockcroft
Pages: 36 - 36
Introduction: Increased arterial stiffness is a marker of cardiovascular disease and suggested to beassociated with impaired lung function in chronic obstructive pulmonary disease (COPD). However, whether patients with mild COPD have increased arterial stiffness and what factors are linked to is still...
Conference Abstract

P8.9 EFFECT OF CARDIAC RESYNCHRONISATION THERAPY ON THE ARTERIAL STIFFNESS

Anna Przybyla*, Danuta Czarnecka
Pages: 36 - 36
Development of cardiac resynchronisation therapy (CRT) in recent years became a breakthrough in treatment of severe heart failure, as it improves exercise capacity, reduces a rate of hospitalisations due to heart failure exacerbation, and the mortality rate, as well as improves quality of patients’ life....
Conference Abstract

P8.10 EFFECTS OF BARIATRIC SURGERY ON ENDOTHELIAL FUNCTION IN EXTREMELY OBESE PATIENTS

Anna Dzieża-Grudnik*, Anna Gαuszewska, Krzysztof Rewiuk, Aleksander Kwater, Bartosz Zarzycki, Maαgorzata Fedyk-Łukasik, Barbara Gryglewska, Tomasz Grodzicki
Pages: 36 - 36
Introduction: Bariatric surgery in extremely obese patients has influence on metabolic variables and body weight however data about influence on flow-mediated dilatation (FMD) of brachial artery are inconsistent. The aim of the study was to assess the effect of bariatric surgery on endothelial function...
Conference Abstract

P8.11 EFFECT OF CARDIAC RESYNCHRONISATION THERAPY ON THE AUTONOMIC NERVOUS SYSTEM FUNCTION

Anna Przybyla*, Danuta Czarnecka
Pages: 36 - 36
Development of cardiac resynchronisation therapy (CRT) in recent years became a breakthrough in treatment of severe heart failure. The aim of this study was evaluation of CRT effect on the autonomous nervous system function. Methods: The study covered a group of 55 patients (45 men, 10 women; mean age...
Research Article

A comparative study of vasa vasorum density among coronary arteries

Keerthana Panchagnula, Rohini Punja, Dhiren Punja, Chinmay Suryavanshi
Pages: 36 - 42
Background: Coronary arteries exhibit significantly higher adventitial Vasa vasorum (VV) densities which may partly explain their higher atherosclerosis susceptibility. A variability in the atherosclerosis predispositions exists between individual coronary artery branches but few studies exist that compare...
Research Article

Endothelin 1 and endothelial dysfunction in children with idiopathic nephrotic syndrome

Venkatesh Arumugam, Abhijeet Saha, Manpreet Kaur, Kanika Kapoor, Nimisha Arora, Trayambak Basak, Shantanu Sengupta, Ajay Bhatt, Nitin Bharadwaj, Vineeta V. Batra, Ashish Datt Upadhyay
Pages: 36 - 40
Background: Endothelial dysfunction is the initial step for atherogenesis. Children with idiopathic nephrotic syndrome are at risk of endothelial dysfunction due to altered cholesterol metabolism which can lead to early atherosclerosis. Methods: In this analytical study with longitudinal follow up 25...
Research Article

ABO blood group differences relationship with coronary atherosclerotic markers

Hussein Nafakhi, Hasan A. Al-Nafakh, Abdulameer A. Al-Mosawi
Pages: 36 - 40
Background: The mechanisms linking ABO blood group to coronary atherosclerosis is inconsistent and not fully understood. Objectives: To investigate the relationship between ABO blood groups with coronary atherosclerotic markers (coronary artery calcification (CAC), coronary plaque presence and coronary...
Research Article

Vascular compliance during insulin infusion and oral glucose challenge

Houry Puzantian, Ari Mosenkis, Raymond R. Townsend
Pages: 36 - 41
Background: Vascular stiffness predicts cardiovascular disease (CVD). Pulse wave velocity (PWV), reflecting vascular stiffness, though determined largely by mean arterial pressure; is also sensitive to insulin and glucose. Capacitance in small (C2) and large vessels (C1), reflecting vascular responsiveness...
Conference Abstract

P8.12 CAROTID ARTERY WAVE INTENSITY ANALYSIS IN HEALTHY HUMANS DURING EXERCISE

Nicola Pomella*, Eurico Wilhelm Neto, Christina Kolyva, Mark Rakobowchuk, Jose Gonzalez-Alonso, Ashraf William Khir
Pages: 37 - 37
Background: The study of wave reflections in the carotid artery may reveal the vasoactive response of the cerebral circulation to exercise, which is not yet fully characterised. Therefore, we aim to examine the effect of exercise on wave intensity parameters measured in the carotid artery of healthy...
Conference Abstract

P8.13 THE ROLE OF HYALURONAN IN AORTIC STIFFENING IN PATIENTS WITH RHEUMATOID ARTHRITIS

Kathleen Connolly*, Kaisa Maki-Petaja, Elizabeth Ribey, Chen Yen Ooi, Sarah Cleary, Ian Wilkinson
Pages: 37 - 37
Growing evidence shows that patients with rheumatoid arthritis (RA) have up to twice the risk of developing cardiovascular disease (CVD) compared to those without RA. Generally, these RA patients have higher levels of inflammation in their bodies, and this inflammation is thought to be the link between...
Conference Abstract

P8.14 ELASTIC MODULUS OF HUMAN AORTAS AS A MEASURE OF STIFFNESS

Kathleen Connolly*, Ashraf Khir, Ye Li, Yasmin Yasmin, Ian Wilkinson
Pages: 37 - 37
Background: Although arterial stiffness is of clinical interest, data on the elastic modulus of the human aortic wall are scarce. The aim of this work is to directly measure the elastic modulus of human aorta ex vivo. Methods: Using a standard tensiometer, we measured the elastic modulus (E) of human...
Conference Abstract

P8.15 THE RELATION BETWEEN ARTERIAL STIFFNESS-RELATED, AND STEADY BLOOD PRESSURE COMPONENTS AND LEFT ATRIAL VOLUME IN THE CONTEXT OF LEFT VENTRICULAR MASS INDEX

Marta Rojek, Jerzy Gasowski*, Marek Rajzer, Tomasz Pizon, Danuta Czarnecka
Pages: 37 - 37
Objective: To check of relation between blood pressure (BP) and arterial stiffness parameters and measures of left atrial volume to verify whether it is the arterial stiffness-related BP parameters or mean arterial pressure (MAP)that could be responsible for increase in risk of atrial fibrillation. Methods:...