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2992 articles
Conference Abstract

P3.2 ROGOZA INDEX IN HEALHY VOLUNTEERS AS A FUNCTION OF AGE

Igor Posokhov
Pages: 11 - 11
Background: Recently, prof Anatoly N Rogoza proposed a new vascular index calculated from one-channel volume sphygmography of brachial artery, Rogoza’s Index or Rogoza Index. It may be useful as a new indicator of asymptomatic vascular damage associated with cardiovascular risk in patients with hypertension. Objective:...
Conference Abstract

P3.3 THE CKD273 URINARY PROTEOMIC BIOMARKER FOR EARLY DIAGNOSIS OF DIABETIC NEPHROPATHY DOES NOT INDICATE GENERALISED SUBCLINICAL VASCULAR DISEASE IN NORMOALBUMINURIC TYPE 2 DIABETIC PATIENTS

Gemma Currie*, Joanne Flynn, Morten Lindhardt, Harald Mischak, Peter Rossing, Christian Delles
Pages: 11 - 11
Background: Diabetic nephropathy (DN) is associated with cardiovascular disease. Microalbuminuria (MA), its traditional hallmark, reflects both renal and generalised vascular damage. We previously established a urinary proteomic classifier (CKD273) for early DN prediction that correlates with other biomarkers...
Conference Abstract

P3.4 PULSE WAVE REFLECTIONS AND THEIR DIURNAL CHANGES IN PATIENTS WITH MARFAN SYNDROME COMPARED TO HEALTHY CONTROLS

Bernhard Hametner*, Matthias Hillebrand, Ghazaleh Nouri, Stephanie Parragh, Jelena Köster, Kai Mortensen, Achim Schwarz, Yskert von Kodolitsch, Siegfried Wassertheurer
Pages: 11 - 11
Introduction: Patients with Marfan syndrome may suffer from a variety of symptoms, including changes of the cardiovascular system. The aim of this study was to perform ambulatory 24 hour blood pressure and pulse wave measurements in a group of Marfan patients and a group of healthy controls and to analyse...
Conference Abstract

P3.5 TYPE 2 DIABETES EXACERBATES CAROTID ARTERY ECHOGENICITY AND CENTRAL ARTERY STIFFNESS IN MIDDLE-AGED AND OLDER INDIVIDUALS

Kunihiko Aizawa*, Francesco Casanova, Dave Mawson, Salim Elyas, Damilola Adingupu, Kim Gooding, David Strain, Angela Shore, Phillip Gates
Pages: 11 - 12
Grey scale median of the common carotid artery intima-media complex (IM-GSM) characterizes the composition of the arterial wall and low IM-GSM reflects more generalized atherosclerotic vulnerability. However, it is unclear whether the presence of DM itself affects IM-GSM, similar to that observed with...
Review Article

The Role of E-health in 24-h Monitoring of Central Haemodynamics and Vascular Function

Stefano Omboni
Pages: 11 - 17
Recent advances in Pulse Wave Analysis (PWA) technology enable Blood Pressure (BP) measuring devices to combine the non-invasive estimation of different vascular biomarkers in ambulatory conditions. This approach allows obtaining a dynamic assessment of vascular function during the 24-h in the conditions...
Research Article

Concomitance of atherosclerotic lesions in arteries of the lower extremities and carotid arteries in patients with abdominal aorta aneurysm

Piotr Kaźmierski, Michał Pająk, Katarzyna Bogusiak
Pages: 11 - 17
Atherosclerosis was considered the main cause of abdominal aorta aneurysms. Many researchers suggest the presence of the association between these two entities. The aim of this paper was to evaluate the presence of atherosclerosis in the aorta and the arteries of the lower extremities, as well as stenoses...
Research Article

Hemodynamic investigation of intraluminal thrombus effect on the wall stress in a stented three-layered aortic aneurysm model under pulsatile flow

Mohammad Alagheband, Shahrokh Rahmani, Mansour Alizadeh, Alireza Karimi, Mahdi Navidbakhsh
Pages: 11 - 19
Purpose: Aortic aneurysms occurs when the wall stress exceeds the strength of the vascular tissue. Intraluminal Thrombus (ILT) may absorb tension and reduce the aortic aneurysm wall stress. The purpose of this study is to test the hypothesis that the presence and growth of ILT alters the wall stress...
Conference Abstract

P3.6 EVALUATION OF DIFFERENT METHODS FOR DETERMINING THE TIME DELAY OF THE ARTERIAL PULSE WAVE: APPLICATION TO THE POPMETRE ®

Hasan Obeid*, Hakim Khettab, Magid Hallab, Pierre Boutouyrie, Stéphane Laurent
Pages: 12 - 12
Objective: Pulse Wave Velocity (PWV) can be measured between different sites. Here we used two different aspects to assess the PWV; the standard method Carotid-Femoral (CF) Sphygmocor (AtCorMedical – Australia) and the pOpmetre ® (Axelife SAS – France) which uses the Finger to Toe (FT) signals. The aim...
Conference Abstract

P3.7 ARTERIAL STIFFNESS IS ASSOCIATED WITH LOWER PERFORMANCE ON THE COGNITIVE TESTS AT DIFFERENT DOMAINS IN HYPERTENSIVE PATIENTS

Henrique Muela, Valéria Costa-Hong, Michel Machado, Natalia Moraes, Claudia Memoria, Monica Yasuda, Ricardo Nogueira, Ayrton Massaro, Edson Shu, Ricardo Nitrini, Luiz Bortolotto*
Pages: 12 - 12
Background: Cognitive impairment and elevated arterial stiffness are described in patients with arterial hypertension (AH), but its correlations are not well studied. Objectives: To study the cognitive function at different domains and arterial properties in patients with AH stage 1 to 3 compared to...
Conference Abstract

P3.8 ARTERIAL STIFFNESS AND LEFT ATRIAL VOLUME IN HYPERTENSIVE AND NORMOTENSIVE SUBJECTS

Marta Rojek, Marek Rajzer*, Danuta Czarnecka
Pages: 12 - 12
Aim: Investigation of relationship between arterial stiffness indices and LAVI in hypertensive and normotensive subjects. Material and methods: Patients were recruited among Morawica town inhabitants. Study group (AH) consisted of 41 untreated hypertensives (20 men). Control group (NonAH)consisted of...
Conference Abstract

P3.9 PROGRESSION OF ARTERIAL STIFFNESS AND VASCULAR LESIONS ACCORDING TO THE DEGREE OF GLYCEMIC ABNORMALITIES. A WARNING IN PATIENTS WITH METABOLIC SYNDROME

Pedro Forcada*, Carlos Castellaro, Jorge Chiabaut, Sergio Gonzalez, Carol Kotliar, Sebastian Obregon
Pages: 12 - 13
Introduction: Metabolic Syndrome (MS), is postulated as intermediate stage in the way to overt DBT, and probably the degree of vascular compromise in this stage could explain the higher proportion of CV complications in diabetics. If so, it should deserve an intensive prevention in MS to reduce DBT complications. Objective:...
Research Article

Associations between smoking and alcohol use and arterial elasticity in patients with newly diagnosed essential hypertension: A cross-sectional study

Noor-Ahmed Jatoi, Waleed-Ibrahim Al-Baker, Afnan Al-Muhanna, Fahad Al-Muhanna, Stella-Maria Kyvelou, Faisal Sharif
Pages: 12 - 18
Objective: To assess the relationship between smoking and alcohol use (separately and combined) on arterial stiffness in patients with essential hypertension. Materials and Methods: We assessed never-treated newly diagnosed patients with essential hypertension (n = 446) aged 18–80 years (52% males)....
Research Article

Left atrial appendage dysfunction in acute embolic stroke young patients with sinus rhythm: Correlation with Tissue Doppler mitral annular systolic velocity

Rania Gaber, Mai Salama
Pages: 12 - 18
Background: Trans-esophageal echocardiogram (TEE) is a gold standard test for diagnosis of left atrial (LA) appendage function. Aim: To evaluate left atrial appendage (LAA) dysfunction using mitral annular systolic velocity measured by tissue Doppler imaging “Sm” in acute embolic stroke young patients...
Research Article

Adiponectin negatively correlated with carotid arterial structure in the leptin-resistant Zucker diabetic fatty rat

Emmanuel Cosson, Paul Valensi, André Bado, Hubert Dabiré
Pages: 12 - 20
Background: Despite adipocytokines are implicated in arterial hemodynamic and stiffness, their effects on arterial histomorphometry remain poorly explored. The aim of the present study was to evaluate, in Zucker Diabetic Fatty (ZDF) rats, a model of type 2 diabetes with leptin resistance, carotid arterial...
Conference Abstract

P3.10 REGIONAL CAROTID MECHANICS IS SIGNIFICANTLY IMPAIRED IN PATIENTS ON HEMODIALYSIS

Oleg Kerbikov*, Ekaterina Borskaya, Irina Kaloshina, Anna Kaloshina, Olga Telnova, Natalia Ustyantseva, Maria Agakina
Pages: 13 - 13
Conference Abstract

P3.14 ASSOCIATION OF CAROTID INTIMA-MEDIA THICKNESS, ENDOTHELIAL FUNCTION AND AORTIC STIFFNESS WITH CARDIOVASCULAR EVENTS IN METABOLIC SYNDROME PATIENTS

Ligita Ryliskyte, Jurate Balsyte*, Jolita Badariene, Roma Puronaite, Rokas Navickas, Svetlana Solovjova, Kristina Ryliskiene, Jurgita Kuzmickiene, Aleksandras Laucevicius
Pages: 13 - 13
Conference Abstract

P3.15 CARDIAC PERFORMANCE VASCULAR PHYSIOLOGY AND ERECTILE STATUS; A QUESTION OF A HEALTHY DIET

Athanasios Angelis*, Nikolaos Ioakeimidis, Mahmoud Abderasoul, Ioanna Gourgouli, Konstantinos Aznaouridis, Dimitrios Terentes, Konstantinos Rokkas, Charalampos Vlachopoulos, Dimitrios Tousoulis
Pages: 13 - 14
Research Article

Aortic Stiffness in HIV Infection with and without Antiretroviral Therapy. A Meta-analysis of Observational Studies

Giovanni Mulè, Giuseppe Mulè, Valeria Tranchida, Pietro Colletti, Giovanni Mazzola, Marcello Trizzino, Claudia Colomba, Antonio Cascio
Pages: 13 - 20
Background: The risk of Cardiovascular (CV) events is higher in HIV-infected patients (HIV+) compared to HIV-uninfected persons (HIV−). Large artery stiffness, a well-documented predictor of adverse CV prognosis, may mediate this enhanced risk. It is usually assessed by measuring aortic Pulse Wave Velocity...
Research Article

Carotid extra-media thickness increases with age, but is not related to arterial stiffness in adults

Hon Lam Choi, Jason S. Au, Maureen J. MacDonald
Pages: 13 - 19
Background: Assessment of carotid artery perivascular adipose tissue through carotid artery extra-media thickness (EMT) ultrasonography has emerged as a novel assessment technique that might contribute unique information to comprehensive evaluations of arterial health. Currently, there is a lack of research...
Review Article

Reducing arterial stiffness and wave reflection – Quest for the Holy Grail?

Azra Mahmud
Pages: 13 - 19
Arterial stiffness and wave reflection are fast emerging as therapeutic targets in their own right. While thiazide diuretics have little or no effect on either arterial stiffness or wave reflection, vasodilators including nitrates and phosphodiesterase type-5 inhibitors e.g., sildenafil, reduce wave...
Conference Abstract

P3.16 CENTRAL ARTERIAL STIFFNESS AND SYSTEMIC VASCULAR RESISTANCE INFLUENCE ON LEFT VENTRICULAR GEOMETRY AND DIASTOLIC FUNCTION IN ESSENTIAL HYPERTENSION

Athanasios Angelis*, Charalampos Vlachopoulos, Nikolaos Ioakimidis, Konstantinos Aznaouridis, Mahmoud Abdelrasoul, Christos Georgakopoulos, Ioannis Felekos, Konstantina Aggeli, Dimitrios Tousoulis
Pages: 14 - 14
Purpose: Vascular resistance remains a key determinant of arterial hypertension and target organ damage alters morbidity of the disease. Our aim is to investigate physiology and clinical relevance of the left ventricular and systemic vascular interaction in essential hypertension patients. Methods:...
Conference Abstract

P3.17 THE EFFECTS OF ALPHA 1-ADRENOCEPTOR-BLOCKADE BY DOXAZOSIN AND ANGIOTENSIN CONVERTING ENZYME-INHIBITION BY RAMIPRIL ON CENTRAL AND BRACHIAL BLOOD PRESSURE AND VASCULAR REACTIVITY IN MILD-TO-MODERATE HYPERTENSION: THE DOXAZOSIN RAMIPRIL STUDY

Andreas Jekell*, Majid Kalani, Thomas Kahan
Pages: 14 - 14
Objectives: To study whether inhibition of the renin-angiotensin-aldosterone system has effects on vascular function beyond blood pressure (BP) reduction alone. Methods: Mild-to-moderate hypertensive patients (age 54±12 years, 34% women) were randomized double-blind to ramipril (10 mg od, n=33) or doxazosin...
Conference Abstract

P3.18 COMPARISON OF STRUCTURAL AND FUNCTIONAL CAROTID AND AORTIC CHANGES IN DIABETES MELLITUS AND HYPERTENSION

Zbigniew Bociąga*, Joanna Jaroch, Ewa Kruszyńska, Maria Łoboz-Rudnicka, Barbara Rzyczkowska, Krystyna Łoboz-Grudzień
Pages: 14 - 14
Background: It is known that age, blood pressure and diabetes mellitus are determinants of arterial stiffness. There are no studies comparing impact of hypertension and diabetes on structural and functional carotid and aortic changes. Aim: The aim of the study was to evaluate structural and functional...
Conference Abstract

P3.19 ASSESSMENT OF CARDIOVASCULAR RISK IN HYPERTENSIVES WITH WHITE COAT EFFECT VS. PATIENTS WITH MASKED UNCONTROLLED HYPERTENSION

Anna Szyndler*, Beata Graff, Jacek Wolf, Katarzyna Polonis, Ewa Swierblewska, Katarzyna Kunicka, Marzena Chrostowska, Krzysztof Narkiewicz
Pages: 14 - 15
Background: According to current ESH guidelines cardiovascular risk assessment is recommended in vast majority of patients with hypertension. However the groups of patients exist where risk assessment may be challenging. Aim: The aim of our analysis was to compare risk factors, and target organ damage...
Research Article

Could BMP-2 and BMP-7 be biomarkers of coronary artery disease? A pilot clinical study

Saeed Nazemi, Atefeh Rezapour, Seyed Mohammad Hasan Moallem, Mohammad Afshar, Sepideh Elyasi, Elham Hashemi, Sheyda Golmohammadzadeh, Azadeh Zaerzadeh, Vahid Jomezadeh, Amir Hooshang Mohammadpour
Pages: 14 - 19
Background: Coronary artery calcification (CAC) is utilized as an important tool for the global risk assessment of cardiovascular events in individuals with intermediate risk. BMP-2 is a powerful inducer of bone formation and exposure to BMP-2 in the arteries leads to the loss of vascular smooth muscle...
Research Article

Viscoelastic mechanical measurement of the healthy and atherosclerotic human coronary arteries using DIC technique

Alireza Karimi, Ahmad Shojaei, Reza Razaghi
Pages: 14 - 21
Purpose: Atherosclerotic is a specific form of vascular disease showed to be in charge of the 30% of mortalities in the United States alone. Many studies so far have been reported on the linear and nonlinear mechanical properties of the human and animal coronary arteries. However, the Quasilinear Viscoelastic...
Review Article

Vascular smooth muscle cell phenotypic modulation and the extracellular matrix

Maryam Heidari, Craig A. Mandato, Stephanie Lehoux
Pages: 14 - 18
Intervascular stents provide clinical benefits in preventing occlusive coronary artery disease after angioplasty, but intimal hyperplasia and restenosis after stent implantation remains an unresolved problem. Vascular smooth muscle cells (VSMCs), the main component of medial layer of arteries, play an...
Research Article

Sleep Quality is associated with Central Arterial Stiffness in Postmenopausal Women: A Cross-sectional Pilot Study

Youngju Choi, Nobuhiko Akazawa, Asako Zempo-Miyaki, Song-Gyu Ra, Seiji Maeda
Pages: 14 - 19
This study aimed to investigate the associations between sleep quality and arterial stiffness in healthy postmenopausal women. A total of 31 healthy postmenopausal women aged between 50 and 74 years participated in this study. Objectively and subjectively measured sleep quantity and quality were concomitantly...
Conference Abstract

P3.21 ASSOCIATIONS OF INSULIN-LIKE GROWTH FACTOR AND ITS BINDING PROTEIN-2 AND 3 WITH BLOOD PRESSURE AND ARTERIAL STRUCTURE AND FUNCTION IN HYPERTENSIVE PERIMENOPAUSAL WOMEN

Agnieszka Olszanecka*, Kalina Kawecka-Jaszcz, Danuta Czarnecka
Pages: 15 - 15
IGFs and their binding proteins are increasingly recognized as important in understanding the pathogenesis of cardiovascular disease. During the transition from premenopause to postmenopause, many women experience weight gain, hence we hypothesized that circulating growth hormones can play a role in...
Conference Abstract

P4.1 ARTERIAL STIFFNESS IN INFLAMMATORY BOWEL DISEASE: A SYSTEMATIC REVIEW

Luca Zanoli*, Stefania Rastelli, Jean-Philippe Empana, Pierre Boutouyrie, Stephane Laurent, Pietro Castellino
Pages: 15 - 15
Background: Arterial stiffness is increased with chronic inflammatory disorders. The reduction of inflammation by immunomodulatory therapy is associated with a restoration of arterial function. Objectives: To determine whether carotid-femoral pulse wave velocity (cf-PWV) is increased in subjects with...
Conference Abstract

P4.2 CORONARY RISK IN RELATION TO GENETIC VARIATION IN MEOX2 AND TCF15 IN A FLEMISH POPULATION

Wen-Yi Yang, Thibault Petit, Lutgard Thijs, Zhen-Yu Zhang, Lotte Jacobs, Azusa Hara, Fang-Fei Wei, Erika Salvi, Lorena Citterio, Yu-Mei Gu, Judita Knez, Nicholas Cauwenberghs, Matteo Barcella, Cristina Barlassina, Paolo Manuta, Tatiana Kuznetsova*, Daniele Cusi, Peter Verhamme, Aernout Luttun, Jan Staessen
Pages: 15 - 15
Aims: In mice, MEOX2/TCF15 heterodimers are highly expressed in heart endothelial cells and are involved in the transcriptional regulation of lipid transport. We investigated whether coronary heart disease (CHD) in humans is associated with variation in these genes. Methods and results: In 2027 participants...
Conference Abstract

P4.3 PHYSICAL ACTIVITY IS ASSOCIATED WITH LOWER ARTERIAL STIFFNESS IN OLDER ADULTS: RESULTS OF THE SAPALDIA 3 COHORT STUDY

Simon Endes*, Emmanuel Schaffner, Seraina Caviezel, Julia Dratva, Christine S. Autenrieth, Miriam Wanner, Brian Martin, Daiana Stolz, Marco Pons, Alexander Turk, Robert Bettschart, Christian Schindler, Nino Künzli, Nicole Probst-Hensch, Arno Schmidt-Trucksäss
Pages: 15 - 16
We examined cross-sectional associations of self-reported PA intensities with arterial stiffness in elderly Caucasians of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA). Mixed central and peripheral arterial stiffness was measured oscillometrically by the cardio-ankle...
Review Article

Vascular adaptation to extreme conditions: The role of hypoxia

Rosa Maria Bruno, Lorenzo Ghiadoni, Lorenza Pratali
Pages: 15 - 21
The study of vascular adaptation to extreme conditions, and in particular to hypoxia, represents a unique opportunity in cardiovascular physiology, with relevant translational implications. First, it has crucial clinical consequences for about 140 million people worldwide living at high altitude and...
Mini Review

Structural proteins and arterial ageing

Michael J. Sherratt
Pages: 15 - 21
In common with most dynamic tissues, the mechanical properties of arteries are determined by the relative composition and architecture of key structural extracellular matrix (ECM) proteins including fibrillar collagens and elastic fibre components. Although it is apparent that age-related loss of ECM...
Research Article

Racial differences in relation between carotid and radial augmentation index☆

Jun Sugawara, Hidehiko Komine, Mutsuko Yoshiwaza, Takashi Tarumi, Seiji Maeda, Hirofumi Tanaka
Pages: 15 - 18
Background: Augmented central artery wave reflection is a cardiovascular disease risk factor. Augmentation index (AI) obtained from peripheral artery waveforms provides qualitatively similar information to AI from central artery waveforms. Little information is available, however, regarding the influence...
Research Article

Non-invasive assessment of allometric scaling laws in the human coronary tree

Damian Craiem, Mariano E. Casciaro, Sebastian Graf, Enrique P. Gurfinkel, Ricardo L. Armentano
Pages: 15 - 23
Assessing the geometry of the coronary arteries in a patient can help to better explain coronary artery disease (CAD) development. Allometric scaling functions were successfully applied to describe how essential materials are transported through recursive networks, also observed in the coronary tree....
Conference Abstract

P4.4 INHIBITION OF ARTERIAL CALCIFICATION BY MATRIX GLA PROTEIN AS DETERMINANT OF RENAL FUNCTION IN THE GENERAL POPULATION

Fangfei Wei*, Nadja E.A. Drummen, Lutgarde Thijs, Lotte Jacobs, Marjo H.J. Knapen, Thibaut Petit, Wenyi Yang, Zhenyu Zhang, Yumei Gu, Tatiana Kuznetsova, Peter Verhamme, Pieter Evenepoel, Cees Vermeer, Jan A. Staessen
Pages: 16 - 16
Background: Carboxylation of matrix Gla protein (MGP), a vitamin K dependent process, activates the protein to a powerful inhibitor of arterial calcification. Circulating dephosphorylated and uncarboxylated MGP (dp-ucMGP) and total uncarboxylated MGP (t-ucMGP) are associated with macrovascular disease....
Conference Abstract

P4.5 VASCULAR HEALTH ASSESSMENT OF THE HYPERTENSIVE PATIENTS (VASOTENS) REGISTRY: RATIONALE, DESIGN AND METHODS OF AN INTERNATIONAL REGISTRY FOR AMBULATORY BLOOD PRESSURE AND ARTERIAL STIFFNESS TELEMONITORING

Stefano Omboni*, Igor N. Posokhov, Gianfranco Parati, Anatoli Rogoza, Alberto Avolio, Ernesto Cardona Muñoz, Lorenzo Ghiadoni, Vladimir Gorbunov, Elena Grigoricheva, Alexandra Konradi, Viktoria Korneva, Yulia Kotovskaya, Natalya Kulikova, Maria Lorenza Muiesan, Giuseppe Mulè, Iana Orlova, Carmine Savoia, Giuseppe Schillaci, Parounak Zelveian, Elena Zheleznyak
Pages: 16 - 16
Background: Ambulatory (A) blood pressure (BP), central BP and pulse wave velocity (PWV) are parameters recommended by hypertension guidelines for estimating BP control and vascular impairment. Recent advances in technology made available devices allowing combined non-invasive estimation of these parameters...
Conference Abstract

P4.6 GREATER CAROTID CIRCUMFERENTIAL WALL STRESS IS ASSOCIATED WITH INCIDENT CARDIOVASCULAR DISEASE IN INDIVIDUALS WITH TYPE 2 DIABETES – THE HOORN STUDY

Veronica Onete*, Ronald Henry, Miranda Schram, Jacqueline Dekker, Giel Nijpels, Coen Stehouwer
Pages: 16 - 17
Introduction: Arterial remodeling is an adaptive phenomenon aimed at maintaining circumferential wall stress (CWS) within operating limits. It is characterized by widening of the inter-adventitial diameter (IAD) and increases in intima-media thickness (IMT). This process is maladaptive when CWS increases...
Research Article

Peripheral blood flow regulation in response to sympathetic stimulation in individuals with down syndrome

Thessa I.M. Hilgenkamp, Sang Ouk Wee, Elizabeth C. Schroeder, Tracy Baynard, Bo Fernhall
Pages: 16 - 21
Background: Individuals with Down syndrome (DS) experience autonomic dysfunction, with reduced sympathetic and parasympathetic control. This results in alterations in resting heart rate and blood pressure and attenuated responses to sympathoexcitatory stimuli. It is unknown to what extent this impacts...
Research Article

Acute effect of coffee consumption on arterial stiffness, evaluated using an oscillometric method

Darío Echeverri, Alejandro Pizano, Félix R. Montes, Pedro Forcada
Pages: 16 - 32
Introduction: Previous studies show contradictory results related to the vascular effects of coffee; they suggest that caffeine increases arterial stiffness and negatively impacts vascular health, the aim of this study is to evaluate the acute coffee effects on the vascular stiffness. Methods and materials:...
Research Article

Longitudinal follow-up of ascending versus abdominal aortic aneurysm formation in angiotensin II-infused ApoE−/− mice

Bram Trachet, M. Renard, C. Van der Donckt, S. Deleye, J. Bols, G.R.Y. De Meyer, S. Staelens, B.L. Loeys, P. Segers
Pages: 16 - 23
Purpose: To explore new imaging techniques to elucidate some of the differences between both abdominal and ascending aortic aneurysms in the angiotensin II mouse model. Procedures: Angiotensin II-infusing pumps were implanted in male ApoE−/− mice (n = 10). In vivo micro-CT, ultrasound and Positron emission...
Conference Abstract

P4.7 PLASMA COPPER AND CERULOPLASMIN IN RELATION TO CAROTID-FEMORAL PULSE WAVE VELOCITY

Katarzyna Stolarz-Skrzypek*, Joanna Platek, Halina Mrowiec, Stanislaw Walas, Wiktoria Wojciechowska, Lukasz Klima, Szczepan Zapotoczny, Kalina Kawecka-Jaszcz, Danuta Czarnecka
Pages: 17 - 17
Copper participates in the redox mechanisms and is a cofactor of enzymes responsible for appropriate structure of elastic fibres. The aim of the study was to assess the relationship between plasma copper as well as ceruloplasmin concentrations and carotid-femoral pulse wave velocity (cfPWV). The study...
Conference Abstract

P4.8 ASSOCIATIONS OF MID-LIFE CARDIOVASCULAR RISK FACTORS WITH LATER LIFE COGNITIVE FUNCTION

Chloe Park*, Therese Tillin, Robert Stewart, Nish Chaturvedi, Alun Hughes
Pages: 17 - 17
Background: Mid-life cardiovascular risk factors may be detrimental to cognitive function in later life; however results are inconsistent. We investigated the impact of mid-life blood pressure, glucose, cholesterol and obesity on cognitive function. Methods: In a community based sample aged 49.6±6years:...
Conference Abstract

P4.9 ENDOTHELIN-1 IS LINKED WITH ARTERIAL STIFFNESS AND INTERLEUKIN-6 IN BLACK SOUTH AFRICAN WOMEN: THE SABPA STUDY

Christine Du Plooy, Ruan Kruger, Carina Mels, Hugo Huisman*
Pages: 17 - 17
Up-regulation of ET-1 activates inflammatory cells such as macrophages that release pro-inflammatory mediators such interleukin-6 which promote vascular inflammation and endothelial dysfunction, leading to arterial stiffness. Included in this study were 194 black and 197 white South-Africans. Cardiovascular...
Conference Abstract

P4.10 ASSOCIATION OF ARTERIAL STIFFNESS WITH BLOOD PRESSURE VARIABILITY

Wiktoria Wojciechowska*, Katarzyna Stolarz-Skrzypek, Agnieszka Olszanecka, Kalina Kawecka-Jaszcz, Danuta Czarnecka
Pages: 17 - 18
Increase of arterial stiffness is an independent predictor of cardiovascular morbidity and mortality. Short term blood pressure (BP) variability is recognised as a marker and a risk factor for cardiovascular complications. The study aims to determine the relation between arterial stiffness and short...
Corrigendum

Corrigendum to “Associations between smoking and alcohol use and arterial elasticity in patients with newly diagnosed essential hypertension: A cross-sectional study” [Artery Res 20 (2017), 12–18]

Noor-Ahmed Jatoi, Waleed-Ibrahim Al-Baker, Afnan Al-Muhanna, Fahad Al-Muhanna, Abdullah Al-Hweish, Abdullah Al-Rubaish, Stella-Maria Kyvelou, Faisal Sharif
Pages: 17 - 17
Research Article

A new statistical phase offset technique for the calculation of in vivo pulse wave velocity

John Runciman, Martine McGregor, Gonçalo Silva, Gabrielle Monteith, Laurent Viel, Luis G. Arroyo
Pages: 17 - 27
Pulmonary blood pressure measurements were collected from 5 clinically healthy horses. Pulse wave velocity (PWV) values were calculated using five techniques, four existing (minimum foot-to-foot, F2F; maximum 1st derivative, M1D; maximum 2nd derivative, M2D; and cross correlation, CC) and the new statistical...
Research Article

A haplotype at the MMP-9 locus is associated with high-blood pressure and arterial stiffness in patients with essential hypertension

Azra Mahmud, Sixiang Zhou, Anthony W. Ryan, Paula Jerrard-Dunne, John Feely
Pages: 17 - 23
Background: Arterial stiffness is an independent predictor of cardiovascular events in hypertensive populations and is in part a heritable trait. Matrix metalloproteinase (MMPs) plays an important role in vascular remolding. MMP-9 levels predict cardiovascular risk and are associated with aortic stiffness....
Conference Abstract

P4.11 ENDOTHELIAL DYSFUNCTION IN URBANIZED AFRICANS WITH LOW PLASMA RENIN LEVELS: THE SABPA STUDY

Johannes van Rooyen*, Rijane Swart, Carina Mels
Pages: 18 - 18
Background and objectives: It is known that high renin levels could damage the vasculature and may cause retinal detachment, stroke, heart failure and kidney failure. The objective of this part of the SABPA study was to determine if renin levels in low and high renin participants could contribute to...
Conference Abstract

P4.12 REFERENCE VALUES OF CENTRAL BLOOD PRESSURE IN ADULTS USING A VALIDATED NON-INVASIVE OSCILLOMETRIC METHOD

Bela Benczur*, Renata Bocskei, Attila Cziraki, Miklos Illyes
Pages: 18 - 18
Central systolic pressure (csBP) is strongly correlated with cardiovascular outcomes than brachial pressure. However, until recently there weren’t widely accepted reference values of csBP established yet. The aim of this work was to determine this missing values of csBP assessed by oscillometric method....
Conference Abstract

P4.13 HERITABILITY AND OTHER DETERMINANTS OF LEFT VENTRICULAR DIASTOLIC FUNCTION IN THE FAMILY-BASED POPULATION STUDY

M. Kloch-Badełek*, V. Tikhonoff, L. Thijs, W. Sakiewicz, K. Stolarz-Skrzypek, K. Narkiewicz, J. Staessen, T. Kuznetsova, K. Kawecka-Jaszcz, D. Czarnecka
Pages: 18 - 18
Background: Understanding to what extent genetic factors influence diastolic Doppler indexes is an important issue in view of the relation of left ventricular (LV) diastolic dysfunction with outcome. We, therefore, investigated in nuclear families recruited from the general population the heritability...
Conference Abstract

P4.14 PREVALENCE OF DIASTOLIC LEFT VENTRICULAR DYSFUNCTION IN EUROPEAN POPULATIONS BASED ON CROSS-VALIDATED DIAGNOSTIC THRESHOLDS

M. Kloch-Badelek*, T. Kuznetsova, W. Sakiewicz, V. Tikhonoff, A. Ryabikov, M. Loster, K. Stolarz-Skrzypek, L. Thijs, K. Narkiewicz, J. Staessen, K. Kawecka-Jaszcz, D. Czarnecka
Pages: 18 - 18
Objective: Different diagnostic criteria limit comparisons between populations in the prevalence of diastolic left ventricular (LV) dysfunction. We aimed to compare across populations age-specific echocardiographic criteria for diastolic LV dysfunction as well as their correlates and prevalence. Methods:...
Research Article

Effects of dynamic range variations on the Doppler flow velocities of common carotid arteries

Donboklang Lynser, Chhunthang Daniala, Aman Yusuf Khan, Evarisalin Marbaniang, Ibamelaker Thangkhiew
Pages: 18 - 23
Introduction: Doppler ultrasound is the commonest diagnostic tool used to evaluate the internal, external and common carotid arteries (CCA). Peak systolic velocity (PSV) is the best Doppler parameter for quantifying carotid artery degree of stenosis. Materials and methods: Normal Doppler waveforms of...
Review Article

Vascular dysfunction: At the heart of cardiovascular disease, cognitive impairment and depressive symptoms☆

T.T. van Sloten
Pages: 18 - 23
Vascular dysfunction may be an important pathway through which ageing and other factors, such as diabetes and obesity, can cause diseases of the heart and brain. Vascular dysfunction includes dysfunction of large arteries (due to arterial stiffness), the microcirculation (microvascular dysfunction) and...
Research Article

Estimates of arterial stiffness and central blood pressure in patients with type 2 diabetes: A comparison of SphygmoCor and Arteriograph

Christoffer Krogager, Niklas B. Rossen, Klavs W. Hansen, Søren T. Knudsen, Christian D. Peters, Hans Erik Bøtker, Per L. Poulsen, Esben Laugesen
Pages: 18 - 24
Background: The Arteriograph is a cuff-based oscillometric device for non-invasive assessment of central systolic blood pressure (cSBP), aortic augmentation index (Aix) and aortic pulse wave velocity (PWV). Reproducibility of Arteriograph measurements and the agreement with SphygmoCor in diabetic patients...
Conference Abstract

P4.15 BLOOD PRESSURE, BODY MASS INDEX AND ARTERIAL ELASTIC PROPERTIES IN YOUNG PEOPLE

Vasyl Yagensky
Pages: 19 - 19
Pulse wave velocity (PWV) is widely used for arterial stiffness assessment. Increased arterial stiffness is a predictor of cardiovascular risk in adults. There are limited data on PWV and its determinants in young people. Study was performed to compare PWV and its association with blood pressure (BP)...
Conference Abstract

P4.16 THE MYOTROPHOBLAST OF THE RAT PLACENTA: EX VIVO STUDY OF NITRIC OXIDE SYNTHASE INHIBITION

Ilana Ariel, Galina Skarzinski, Vitali Belzer, Wiessam Abu-Ahmad, Zaid Abassi, Michael Bursztyn*
Pages: 19 - 19
Introduction: Endovascular trophoblasts (EVasT) of the rat express smooth muscle (SM) proteins and contract ex vivo upon exposure to endothelin-1 (ET1). Contraction is mediated via ET1 receptors A and B (ETA, ETB). In vascular SM ETB, in variance from ETA, exerts relaxation through activation of nitric...
Conference Abstract

P4.17 ARTERIAL STIFFNESS IN YOUNG PATIENTS WITH PERIPHERAL ARTERIAL DISEASE

Mariella Catalano*, Giovanni Scandale, Gabriel Dimitrov, Marzio Minola, Martino Recchia, Francesca Galli, Gianni Carzaniga, Maria Carotta
Pages: 19 - 19
Increased arterial stiffness occurs in older patients with peripheral arterial disease (PAD). In this study we compared arterial stiffness and central hemodynamic parameters in young (< 60 years of age) PAD patients and controls. In 31 PAD patients with an ankle-brachial index (ABI≤ 0.9) and 42 controls,...
Conference Abstract

P4.18 THE ASSUMPTION THAT BLOOD PRESSURE DECREASES OVER CONSECUTIVE MEASUREMENTS IS FALSE: MAJOR IMPLICATIONS FOR HYPERTENSION DIAGNOSIS AND GUIDELINES

Panagiota Veloudi*, Leigh Blizzard, Velandai Srikanth, Martin Schultz, James E. Sharman
Pages: 19 - 19
Background: There is anecdotal belief that clinic blood pressure (BP) drops over consecutive measurements. This has led to guideline recommendations to discard the first BP reading, or take only one reading if systolic BP (SBP) <140 mmHg. However, the magnitude and direction of change in SBP over...
Conference Abstract

P4.19 CARDIOVASCULAR RISK FACTORS AND LEFT VENTRICULAR HYPERTROPHY IN CHILDREN WITH CHRONIC KIDNEY DISEASE

Dorota Drozdz*, Przemko Kwinta, Zbigniew Kordon, Katarzyna Zachwieja, Monika Miklaszewska, Krystyna Sztefko, Andrzej Rudzinski, Jacek Antoni Pietrzyk
Pages: 19 - 20
Cardiovascular diseases are substantial causes of mortality among patients with chronic kidney disease (CKD). The aim of the study was an assessment of the impact of cardiovascular risk factors on left ventricular hypertrophy (LVH) in children with CKD. Material and methods: The study was conducted...
Research Article

Treatment of White Coat HYpertension in the Very Elderly Trial (HYVET 2) - Feasibility of a Randomized Controlled Trial (Study Protocol)

Michael Okorie, Khalid Ali, Stephen Bremner, Nigel Beckett, Stephen Jackson, Richard Quirk, Colin McAlister, Nicky Perry, John Potter, Christopher Bulpitt, Chakravarthi Rajkumar
Pages: 19 - 25
The results of HYpertension in the Very Elderly Trial (HYVET) were crucial in providing evidence of benefit of the treatment of hypertension in those 80 years or older. Following a subsequent sub study analysis of the HYVET data there is a suggestion that 50% of patients in the main study had White Coat...
Research Article

Pulse pressure measured at the level of the femoral artery, but not at the level of the aorta, carotid and brachial arteries, is associated with the incidence of coronary heart disease events in a population with a high prevalence of type 2 diabetes and impaired glucose metabolism – The Hoorn study

A.D. Protogerou, T.T. van Sloten, R.M.A. Henry, J.M. Dekker, Giel Nijpels, C.D.A. Stehouwer
Pages: 19 - 26
Introduction: Central (aortic or carotid) pulse pressure (PP) is more strongly associated with local organ damage and possibly mortality than brachial PP. Aim: To investigate for the first time the association of femoral (f) PP with all-cause mortality, and incident cardiovascular disease (CVD), coronary...
Research Article

Performance assessment of pulse wave imaging using conventional ultrasound in canine aortas ex vivo and normal human arteries in vivo

Ronny X. Li, William Qaqish, Elisa E. Konofagou
Pages: 19 - 28
The propagation behavior of the arterial pulse wave may provide valuable diagnostic information for cardiovascular pathology. pulse wave imaging (PWI) is a noninvasive, ultrasound imaging-based technique capable of mapping multiple wall motion waveforms along a short arterial segment over a single cardiac...
Research Article

The assessment of carotid–femoral distance for aortic pulse wave velocity: Should it be estimated from body height?☆

Jan Filipovský, Otto Mayer, Milena Dolejšová, Jitka Seidlerová
Pages: 19 - 23
Background: Aortic pulse wave velocity (PWV) can be biased by the measurement of carotid–femoral (c-f) distance on body surface. We wondered whether the estimation of distance according to body height could be used. Methods: Three cohorts of altogether 596 subjects (mean age 58.9 years) were studied....
Conference Abstract

P4.20 ASSESSMENT OF BODY COMPOSITION USING BIOELECTRICAL IMPEDANCE ANALYSIS AND BLOOD PRESSURE IN HEALTHY SCHOOL CHILDREN

Monika Latka, Dorota Drozdz*, Tomasz Drozdz, Kinga Wojtowicz, Przemko Kwinta, Jacek Antoni Pietrzyk
Pages: 20 - 20
Introduction: Bioimpedance analysis (BIA) is becoming more widely used in clinical practice to measure water body compartments. BIA allows to calculate: total body water (TBW), lean body mass (LBM), fat mass (FM), intra- and extracellular water (ICW, ECW). Aim: The aim of this study was to evaluate...
Conference Abstract

P4.21 MICROCIRCULATION EFFECTS OF OBESITY AND/OR DIET: A PRELIMINARY STUDY IN MICE

Nicole Di Lascio*, Francesca Lenzarini, Cristina Barsanti, Francesco Stea, Claudia Kusmic, Francesco Faita
Pages: 20 - 20
Obesity is becoming a global epidemic and is associated with cardiovascular disease. Genetic factors play a significant role in the disease etiology but less is known about the interaction between genes and diet composition. This study is aimed to investigate the effect of diet and/or genotype on microcirculation...
Conference Abstract

P5.1 FROM AORTIC FLOW VELOCITY TO CENTRAL PRESSURE: A NON-INVASIVE PROOF OF CONCEPT

Samuel Vennin*, Jordi Alastruey, Phil Chowienczyk
Pages: 20 - 20
Estimation of aortic and left ventricular (LV) pressure usually requires measurements that are difficult to acquire during the imaging required to obtain concurrent LV dimensions essential for determination of LV mechanical properties. We describe a novel method for deriving aortic pressure from the...
Conference Abstract

P5.2 FROM THE WAVE PROPAGATION MODEL TO A TRANSFER FUNCTION: A POSSIBILITY FOR PERSONALISATION

Bernhard Hametner*, Stephanie Parragh, Anita Gerstenmayer, Thomas Weber, Siegfried Wassertheurer
Pages: 20 - 21
Since aortic pressure cannot be measured noninvasively, pressure signals are often measured at more superficial arteries and a transfer function is applied to obtain a surrogate for the central pressure curve. These transformations are usually derived from measurements in a specific group of subjects...
Research Article

Porphyromonas gingivalis vesicles reduce MDA-LDL levels and aortic wall thickness in high fat diet induced atherosclerosis rats

Aditya Indra Mahendra, Jonny Karunia Fajar, Harapan Harapan, Teuku Heriansyah, Sumarno Reto Prawiro, Edi Widjajanto, Mohammad Saifur Rohman, Karyono Mintaroem, Budi Susetio Pikir, Yash Prashar
Pages: 20 - 27
Background: Recently, atherosclerosis-associated disease has been reported simultaneously increased. Whereas, to date, no atherosclerosis vaccine is available. Since the epitope mimicry between malondialdehyde low-density lipoprotein (MDA-LDL) and arginine specific epitope gingipain (Rgp) on the Porphyromonas...
Research Article

IL-17 producing CD4+CD45RO+ T-cells in atherosclerosis express GITR molecule

Atefe Ghamar Talepoor, Negar Behnamfar, Mohammad Javad Zibaeenezhad, Mehrnoosh Doroudchi
Pages: 20 - 28
Background: Atherosclerosis (AS) is a chronic inflammatory disease of vessel walls associated with infiltration of immune cells which their function is controlled by different co-stimulatory and co-inhibitory receptors. We investigated the expression of co-inhibitory molecules on the memory and effector...
Research Article

Vitamin E attenuates alcohol-induced aortic wall damage in rats

Leila Norouzi, Alireza Shirpoor, Mohammad-Hasan Khadem Ansari, Behrouz Ilkhanizadeh
Pages: 20 - 26
Background: In this study the effect of chronic ethanol consumption on vascular wall abnormality via oxidative stress was examined. It was also intended to find out whether vitamin E inhibits the abnormality induced by ethanol in rat vascular wall. Methods: Twenty-four male wistar rats were divided...
Research Article

Sodium excretion as a modulator of genetic influence on arterial stiffness and other cardiovascular phenotypes

Katarzyna Stolarz, Tatiana Kuznetsova, Wiktoria Wojciechowska, Jitka Seidlerova, Edoardo Casiglia, Jan Filipovský, Jan Peleška, Yuri Nikitin, Jan A. Staessen, Kalina Kawecka-Jaszcz,
Pages: 20 - 25
Hypertension is a chronic age-related disorder, affecting nearly 20% of all adult Europeans. This disease entails debilitating cardiovascular complications and is the leading cause for drug prescriptions in Europeans older than 50 years. Intensive research over the past two decades has so far failed...
Research Article

Hemodynamic Data Analysis and Site of Measurement in Children and Adolescents

Mirjam Močnik, Nataša Marčun Varda
Pages: 20 - 24
Pulse wave velocity is a method of functional vascular evaluation. The gold standard is the carotid-femoral pulse wave velocity measurement. However, the software allows measurement among radial, carotid and femoral artery. The goal of our prospective pilot study was to compare pulse wave velocity measurement...
Conference Abstract

P5.3 CHARACTERIZATION OF THE BIOMECHANICS OF THE RAT XENOGRAFT MODEL OF ABDOMINAL AORTIC ANEURYSM BY RING TEST

Louise Marais*, Jianping Dai, Eric Allaire, Mustapha Zidi
Pages: 21 - 21
Setting up new strategies to prevent the growth and fatal rupture of aneurysms remains a challenge. The rat xenograft model of abdominal aortic aneurysm (AAA) has been used to develop gene and cell therapies with the aim of countering the expansion of the diseased arterial wall. It is of primary importance...
Conference Abstract

P5.4 CENTRAL PRESSURE APPRAISAL: CLINICAL VALIDATION OF A SUBJECT-SPECIFIC MATHEMATICAL MODEL

Francesco Tosello, Andrea Guala*, Dario Leone, Carlo Camporeale, Giulia Bruno, Luca Ridolfi, Franco Veglio, Alberto Milan
Pages: 21 - 21
Increased blood pressure represents a major cardiovascular risk factor for western populations. Usually blood pressure is measured peripherally, but current evidence suggested that central blood pressure better predicts cardiovascular events. However, central blood pressure measurement is not feasible...
Conference Abstract

P5.5 COMPENSATORY EFFECT BETWEEN AORTIC STIFFENING AND REMODELLING DURING AGEING

Andrea Guala*, Carlo Camporeale, Luca Ridolfi
Pages: 21 - 21
The arterial tree exhibits a complex spatio-temporal wave pattern, whose healthy behaviour depends on a balance between mechanical and geometrical properties. Several clinical studies demonstrated that this balance progressively breaks down during ageing, when the aorta stiffens and remodels. This dual...
Conference Abstract

P5.6 CORONARY FLUID MECHANICS IN AN AGEING CARDIOVASCULAR SYSTEM

Andrea Guala*, Michele Scalseggi, Luca Ridolfi
Pages: 21 - 21
Coronary artery diseases are the most common type of cardiovascular diseases and have an increasing prevalence with age. Epidemiological studies demonstrated that coronary failure is associated with several pathologies (as atherosclerosis, hypertension, diabetes, endothelial dysfunction, renal insufficiency)....
Research Article

Real-world Accuracy of Transthoracic Echocardiography in Diagnosing Bicuspid Aortic Valve Morphology: A Single Center UK Experience

Oliver James Harrison, Abdul Badran, Amer Harky, Daniel Muller, Benoy N. Shah, Sunil K. Ohri
Pages: 21 - 26
Objectives: The aim of this study was to compare the diagnostic accuracy of Transthoracic Echocardiography (TTE) in assessing Bicuspid Aortic Valve (BAV) morphology. Methods: Case notes of 408 patients (>18 years old) undergoing elective Aortic Valve (AV) surgery over a 2-year period were retrospectively...
Review Article

Turner syndrome and guidelines for management of thoracic aortic disease: Appropriateness and utility

Hisham M.F Sherif
Pages: 21 - 29
Introduction: Current guidelines for management of thoracic aortic disease base clinical decision-making primarily on the aortic size. The risk of serious complications in genetically-triggered aortic disease is influenced by many other factors, currently not taken into account by the guidelines. Methods:...
Research Article

Hepatic arterial changes following iodized oil chemoembolization of hepatocellular carcinoma: Incidence and technical consequence

Ron C. Gaba, Tamara R. Brodsky, M. Grace Knuttinen, Benedictta O. Omene, Charles A. Owens, James T. Bui
Pages: 21 - 27
Objective: To describe the nature, incidence, and therapeutic consequence of hepatic arterial changes seen following transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). Methods: In this retrospective study, 46 patients with HCC underwent ≥ 2 TACE treatment sessions between...
Review Article

Identifying the vulnerable plaque: A review of invasive and non-invasive imaging modalities

Jan G. Kips, Patrick Segers, Luc M. Van Bortel
Pages: 21 - 34
Atherosclerotic cardiovascular disease is the current leading cause of death in industrialized countries. The vast majority of acute cardiovascular events (50–70%) are ascribed to thrombosis following rupture of a vulnerable plaque. Therefore there is an urgent need to discern vulnerable, unstable plaques...
Conference Abstract

P5.7 A DATABASE OF VIRTUAL HEALTHY SUBJECTS AS A NEW TOOL TO ASSESS PHYSIOLOGICAL INDEXES AND ALGORITHMS BASED ON WAVE PROPAGATION

Marie Willemet*, Phil Chowienczyk, Samuel Vennin, Jordi Alastruey
Pages: 22 - 22
Many physiological indexes and algorithms based on pulse wave analysis have been suggested in order to better understand the physiology of arterial hemodynamics (e.g. pulse wave velocity, transfer functions for central blood pressure derivation). Because these tools are most often computed from hemodynamic...
Conference Abstract

P5.8 TOWARDS IN VIVO BIAXIAL CHARACTERISATION OF CAROTID ARTERY MECHANICS

Robert Holtackers*, Bart Spronck, Maarten Heusinkveld, Geneviève Crombag, Jos Op ’t Roodt, Tammo Delhaas, Eline Kooi, Evelien Hermeling, Koen Reesink
Pages: 22 - 22
Background: The relative content and loading of collagen and elastin in the arterial wall determine in vivo longitudinal pre-stretch. Assessment of arterial distensibility at varying longitudinal pre-stretch could improve characterisation of arterial collagen-elastin matrix properties. We introduce a...
Conference Abstract

P5.9 CARDIAC AND ARTERIAL CONTRIBUTION TO BLOOD PRESSURE CHANGES WITH AGE

Elira Maksuti*, Nico Westerhof, Berend Westerhof, Michael Broomé, Nikos Stergiopulos
Pages: 22 - 22
During aging, systolic blood pressure (Ps) continuously increases over time, whereas diastolic pressure (Pd) first increases and then slightly decreases after middle-age. These pressure changes are usually explained by changes of the arterial system alone (increase in arterial stiffness and vascular...
Conference Abstract

P5.10 CHANGES IN MECHANICAL PROPERTIES OF FEMORAL ARTERY WALLS IN PIG MODEL OF ARTERIOSCLEROSIS

Robert Pasławski
Pages: 22 - 22
Arteriosclertic lesions leading to increased stiffnes of the walls. The goal of the research was to estimate changes in the mechanical properties of femoral artery in swine with experimentally induced arteriosclerotic changes by western type diet. Methods: 32 white female pigs (40 kg), were divided...
Conference Abstract

P5.11 ROLE OF PRESSURE-DEPENDENT ARTERIAL OMPLIANCE IN MODULATING THE PHASE OF WAVE REFLECTIONS: IMPLICATIONS FOR LV-AS COUPLING

Timothy Phan*, John Li
Pages: 22 - 23
Background: Arterial compliance is pressure-dependent due to the nonhomogeneous composition of the arterial wall. Wall distending pressure varies within each cardiac cycle, thus arterial compliance is dynamic and time-varying within any given cycle. As compliance is a component of the pulsatile load...
Research Article

Combinatorial effect of lower extremity blood flow restriction and low intensity endurance exercise on aorta of old male rats: Histomorphological and molecular approach

Mohammad-Abbas Bejeshk, Siyavash Joukar, Beydolah Shahouzehi, Majid Asadi-shekari, Mohammadamin Rajizadeh, Alireza Raji-amirhasani, Vida Naderi-boldaji
Pages: 22 - 31
Objective: Given the importance of knowing the effects of blood flow restriction (BFR) plus exercise training (BFR training) on the cardiovascular system, present study conducted to determine the effect of combination of BFR with low intensity endurance exercise on aorta of old rats. Methods: Animal...
Research Article

Abdominal aortic size and volume by computed tomography angiography in population of Ukraine: Normal values by age, gender, and body surface area

Andriy Nykonenko, Andrei Balyuta, Yevhen Haidarzhi, Yevgen Yermolayev, Ivan Pertsov, Olexandr Nykonenko
Pages: 22 - 26
Background: Computed tomography angiography (CTA) is a standard tool for investigation of the abdominal aorta diseases. Currently, there are only a few published scientific articles devoted to the study of the infrarenal aortic size without pathology. The aim of the current work was to examine the indicators...
Research Article

Noninvasive evaluation of varying pulse pressures in vivo using brachial sphymomanometry, applanation tonometry, and Pulse Wave Ultrasound Manometry

Ronny X. Li, Ada Ip, Elena Sanz-Miralles, Elisa E. Konofagou
Pages: 22 - 28
The routine assessment and monitoring of hypertension may benefit from the evaluation of arterial pulse pressure (PP) at more central locations (e.g. the aorta) rather solely at the brachial artery. Pulse Wave Ultrasound Manometry (PWUM) was previously developed by our group to provide direct, noninvasive...
Research Article

Anatomic variations of the renal arteries from a local study population using 3D computed tomography angiography reconstruction images from a reference hospital in Cali, Colombia

Juan S. Calle Toro, Gabriel Prada, Sara Yukie Rodriguez Takeuchi, Robinson Pachecho, Gloria Baena, Ana M. Granados
Pages: 22 - 26
Purpose: With the advances in the new image techniques and 3D modeling, angiography computed tomography (A-CT) has became a very useful image for studying vessels. Renal artery (RA) variations are common, and have a clinical relevance in pre-operative planning. There are several descriptive studies made...
Mini Review

Arterial stiffening: Causes and consequences

Marina Cecelja, Phil Chowienczyk
Pages: 22 - 27
Increased arterial stiffness, as measured by pulse wave velocity, is increasingly recognised as an important predictor of future cardiovascular events. At present, the mechanisms leading to stiffening of large arteries and the processes underlying the association between arterial stiffness and cardiovascular...
Conference Abstract

P5.13 ESTIMATION OF CENTRAL SYSTOLIC PRESSURE: ARE PERIPHERAL WAVEFORMS AND TRANSFER FUNCTION NECESSARY?

Denis Chemla*, Sandrine Millasseau, Edmund Lau, P. Attal, Alain Nittenberg
Pages: 23 - 23
Background and aim: The degree of systolic pressure amplification (SPamp) from aorta to brachial artery depends on a number of variables including age, gender, heart rate and arterial stiffness. It is admitted that central systolic blood pressure (cSBP) cannot be predicted with sufficient accuracy from...
Conference Abstract

P5.14 THIGH-CUFF BASED MEASUREMENT OF AORTIC PULSE WAVE VELOCITY: INITIAL TESTING OF A NOVEL VASERA PROTOTYPE DEVICE

Francisco Londoño*, Daime Campos, Shigeo Horinaka, Julio Chirinos, Patrick Segers
Pages: 23 - 23
Introduction: Fully automated cuff-based devices have been developed for the assessment of arterial stiffness via pulse wave velocity (PWV) measurement, such as the VaSera device (Fukuda Denshi). To date, measurements were confined to the heart-to-ankle segment, yielding PWV and stiffness indices that...
Conference Abstract

P5.15 EVALUATION OF AORTIC 18F-NAF TRACER UPTAKE DETECTED USING PET/CT IN PREDICTING AORTIC CALCIFICATION OVER A 4-YEAR FOLLOW-UP PERIOD

Marina Cecelja*, Amelia Moore, Ignac Fogelman, Michelle Frost, Phillip Chowienczyk
Pages: 23 - 23
Background: Uptake of 18F-sodium fluoride (18F-NaF) in the aortic wall may reflect metabolically active areas of calcification, an important predictor of cardiovascular morbidity and mortality when detected by computed tomography (CT). The aim of this project was to determine if 18F-NaF uptake in the...
Conference Abstract

P5.17 CAROTID PULSE PRESSURE ASSESSMENT BY MEANS OF AN ACCELEROMETRIC SENSOR

Nicole Di Lascio*, Vincenzo Gemignani, Rosa Maria Bruno, Elisabetta Bianchini, Francesco Stea, Lorenzo Ghiadoni, Francesco Faita
Pages: 23 - 24
Central pulse pressure (cPP) is increasingly investigated as possible independent predictor of cardiovascular risk and carotid pulse pressure (carPP) can be used as a surrogate marker of cPP. Despite its importance, carPP measurement remains challenging in clinical practice. The aim of this study was...