Neupogen (Filgrastim) Induced Acute Hematuria/Proteinuria with 3 Days of Use in a 7-Year-old Boy Diagnosed as Aplastic Anemia

Authors

Sohail Azam^{1, *,} , Hassan Eliwan², Fatima Eltayeb Hago¹, Al Husein Mohammed Chyad Hammoudi³

¹Department of Inpatient Pharmacy, Dr Sulaiman Al-Habib Hospital, Arryan, Riyadh, Saudi Arabia

²Department of Pediatric, Dr Sulaiman Al-Habib Hospital, Arryan, Riyadh, Saudi Arabia

³Department of Clinical Therapies, University of Limerick, Limerick, Ireland

^*Corresponding author. Email: asksohail@hotmail.com; Sohail.Azam@drsulaimanalhabib.com

DOI

10.2991/dsahmj.k.200704.001How to use a DOI?

Keywords

Filgrastim; neupogen; G-CSF; hematuria; adverse effect; pediatrics

Abstract

Filgrastim, a granulocyte-colony stimulating factor (G-CSF), is used in patients with neutropenia caused by chemotherapy, bone marrow transplant, radiation poisoning, or any unknown etiology. It stimulates the bone marrow to increase the production of neutrophils. Although it has a good safety and efficacy profile, many patients experience different side effects ranging from mild symptoms such as abdominal pain, musculoskeletal pain, diarrhea, and headache, to severe symptoms/conditions such as splenic rupture, anaphylactic reaction, pulmonary hemorrhage, and hypoxia. Hematuria/proteinuria is one of the uncommon side effects seen in patient using Filgrastim for a longer period. However, to date there is no reported case of Filgrastim-induced hematuria with only 3 days of use. We report a case of a 7-year-old boy who developed hematuria with only three doses of Filgrastim and was diagnosed to have aplastic anemia.

Copyright

© 2020 Dr. Sulaiman Al Habib Medical Group. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Sohail Azam
AU  - Hassan Eliwan
AU  - Fatima Eltayeb Hago
AU  - Al Husein Mohammed Chyad Hammoudi
PY  - 2020
DA  - 2020/07/07
TI  - Neupogen (Filgrastim) Induced Acute Hematuria/Proteinuria with 3 Days of Use in a 7-Year-old Boy Diagnosed as Aplastic Anemia
JO  - Dr. Sulaiman Al Habib Medical Journal
SP  - 92
EP  - 94
VL  - 2
IS  - 3
SN  - 2590-3349
UR  - https://doi.org/10.2991/dsahmj.k.200704.001
DO  - 10.2991/dsahmj.k.200704.001
ID  - Azam2020
ER  -