Artery Research

Volume 26, Issue 2, June 2020, Pages 97 - 101

Does the Nitric Oxide Synthase T786C Gene Polymorphism Influence Arterial Stiffness in Patients with Metabolic Syndrome?

Authors
Angela Cozma1, , Adriana Fodor2, , Lucia Maria Procopciuc3, Teodora Alexescu1, Vasile Negrean1, Dana Pop4, Doina Alina Todea5, Olga Hilda Orăşan1, *, Adela-Viviana Sitar-Taut1
1Internal Medicine Department, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
2Clinical Center of Diabetes, Nutrition, Metabolic diseases, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
3Department of Medical Biochemistry, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
4Department of Cardiology, Clinical Rehabilitation Hospital, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
5Department of Pneumology, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania

These authors contributed equally to this work.

*Corresponding author. Email: olgaorasan@yahoo.com
Corresponding Author
Olga Hilda Orăşan
Received 15 March 2019, Accepted 24 March 2020, Available Online 4 April 2020.
DOI
10.2991/artres.k.200324.001How to use a DOI?
Keywords
eNOS gene polymorphisms; T786C; arterial stiffness; metabolic syndrome
Abstract

Background: Endothelial Nitric Oxide Synthase (eNOS) is responsible for Nitric Oxide (NO) bioavailability at endothelial level. Aging (even in healthy people) is involved in arterial stiffness increases.

Materials and Methods: We investigated (in the service of Cardiology, 4th Medical Clinic) 100 patients, 55 with metabolic syndrome (MS), mean age 56.91 ± 14.39 years, 66% women. Identification of the T786C polymorphism was performed by enzymatic digestion of the fragment obtained by polymerase chain reaction (PCR) amplification. Evaluation of arterial parameters (aortic pulse wave velocity (PWV), as a measure of arterial stiffness and aortic [AixAo] and brachial [Aixb] augmentation index) was performed with the TensioMed Arteriograph.

Results: Regarding T786C polymorphism, the distribution was the following: 57% did not have the mutation (TT), 30% were heterozygous, 13% were homozygous (CC). Patients with MS more frequently had C allele (54.5% vs. 28.9% in those without MS) and CC state (16.4% vs. 8.9%, p-NS). Significant differences (p = 0.005) regarding PWV were found in TT patients vs. heterozygous CT vs. homozygous CC: 9.75 ± 1.75 m/s vs. 9.86 ± 1.56 m/s vs. 11.65 ± 1.87 m/s. In case of the other parameters, no significant differences were found (AixAo, p = 0.35; Aixb, p = 0.22; pulse pressure, p = 0.14), but CC patients presented higher values.

Conclusion: Arterial stiffness is influenced by eNOS gene polymorphisms, being a possible link between the increase in cardiovascular risk and presence of metabolic syndrome in these patients.

Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Artery Research
Volume-Issue
26 - 2
Pages
97 - 101
Publication Date
2020/04/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.200324.001How to use a DOI?
Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Angela Cozma
AU  - Adriana Fodor
AU  - Lucia Maria Procopciuc
AU  - Teodora Alexescu
AU  - Vasile Negrean
AU  - Dana Pop
AU  - Doina Alina Todea
AU  - Olga Hilda Orăşan
AU  - Adela-Viviana Sitar-Taut
PY  - 2020
DA  - 2020/04/04
TI  - Does the Nitric Oxide Synthase T786C Gene Polymorphism Influence Arterial Stiffness in Patients with Metabolic Syndrome?
JO  - Artery Research
SP  - 97
EP  - 101
VL  - 26
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.200324.001
DO  - 10.2991/artres.k.200324.001
ID  - Cozma2020
ER  -