Early Initiation of ARV Therapy Among TB–HIV Patients in Indonesia Prolongs Survival Rates!

Siti Maemun; Nina Mariana; Adria Rusli; Renti Mahkota; Tri Bayu Purnama

doi:10.2991/jegh.k.200102.002

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Volume 10, Issue 2, June 2020, Pages 164 - 167

Early Initiation of ARV Therapy Among TB–HIV Patients in Indonesia Prolongs Survival Rates!

Authors

Siti Maemun¹^{, †}, Nina Mariana², Adria Rusli², Renti Mahkota³, Tri Bayu Purnama⁴^{, *}

¹Department of Epidemiology, Faculty of Public Health, University of Indonesia

²Prof. Dr. Sulianti Saroso Infectious Disease Hospital, Jakarta

³Department of Public Health, University of Respati Indonesia, Jakarta, Indonesia

⁴Department of Biostatistics and Epidemiology, Faculty of Public Health, Universitas Islam Negeri Sumatera Utara, Medan, Indonesia

^†

Prof. Dr. Sulianti Saroso Infectious Disease Hospital, Jakarta; Department of Public Health, University of Respati Indonesia, Jakarta, Indonesia

^*Corresponding author. Email: tbayu93@gmail.com

Corresponding Author

Tri Bayu Purnama

Received 17 July 2019, Accepted 21 December 2019, Available Online 13 January 2020.

DOI: 10.2991/jegh.k.200102.002 How to use a DOI?
Keywords: Antiretroviral; TB–HIV coinfection; Survival analysis
Abstract: Background: The HIV epidemic remains a public health problem with rising tuberculosis (TB) numbers around the world. Antiretroviral (ARV) therapy (ART) is essential to increase the survival of patients with TB–HIV coinfection. The aim of this study is to investigate the effect of ARV treatment initiation within TB treatment duration for the survival of patients with TB–HIV coinfection.

Methods: This is a retrospective cohort study of patients with TB–HIV coinfection and who were ARV naive from Prof. Dr. Sulianti Saroso Infectious Disease Hospital between January 2011 and May 2014 (N = 275). The Kaplan–Meier method, bivariate with the log rank test, and multivariate with the Cox regression were applied in this study.

Results: Cumulative survival probability of the patients with TB–HIV coinfection receiving ARV in a year was 81.5%. The death rate in patients with TB–HIV coinfection who received late ART initiation during TB treatment is higher by 2.4 times [adjusted hazard ratio (aHR) = 2.4, 95% confidence interval: 1.3–4.5, p = 0.006] compared with the patients who were in early ART initiation and were thereafter adjusted by the location of Mycobacterium tuberculosis infection.

Conclusion:The effect of ART initiation is essential in the intensive phase (2–8 weeks) of anti-TB medication to increase the survival among TB–HIV coinfection group.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal: Journal of Epidemiology and Global Health
Volume-Issue: 10 - 2
Pages: 164 - 167
Publication Date: 2020/01/13
ISSN (Online): 2210-6014
ISSN (Print): 2210-6006
DOI: 10.2991/jegh.k.200102.002 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Siti Maemun
AU  - Nina Mariana
AU  - Adria Rusli
AU  - Renti Mahkota
AU  - Tri Bayu Purnama
PY  - 2020
DA  - 2020/01/13
TI  - Early Initiation of ARV Therapy Among TB–HIV Patients in Indonesia Prolongs Survival Rates!
JO  - Journal of Epidemiology and Global Health
SP  - 164
EP  - 167
VL  - 10
IS  - 2
SN  - 2210-6014
UR  - https://doi.org/10.2991/jegh.k.200102.002
DO  - 10.2991/jegh.k.200102.002
ID  - Maemun2020
ER  -

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