Artery Research

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Volume 12, Issue C, December 2015, Pages 46 - 46

5.4 MATRIX GLA PROTEIN IN RELATION TO LEFT VENTRICULAR DIASTOLIC FUNCTION

Authors
Thibault Petit*1, Zhen-Yu Zhang1, Wen-Yi Yang1, Fang-Fei Wei1, Yu-Mei Gu1, Juditha Knez1, Nicholas Cauwenberghs1, Yan-Ping Liu1, Nadja Drummen2, Lotte Jacobs1, Lutgarde Thijs1, Tatiana Kuznetsova1, Stefan Janssens3, Cees Vermeer2, Jan A. Staessen1, 2
1Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium
2R & D VitaK Group, Maastricht University, Maastricht, The Netherlands
3Centre for Molecular and Vascular Biology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.029How to use a DOI?
Abstract

Introduction: Matrix Gla Protein (MGP) is highly expressed in cardiomyocytes and is upregulated after acute and chronic pressure overload and in myocardial hypertrophy in mice and humans. However, no study addressed the relation between cardiac function and MGP in humans.

Methods and results: In 767 participants randomly recruited from the Flemish population (51.5% women, mean age 50.6 years), we measured circulating levels of nonphosphorylated and uncarboxylated MGP (dp-ucMGP) and recorded early and late diastolic peak velocities of mitral inflow (E and A) by conventional Doppler and the mitral annular velocities (e′ and a′) by tissue Doppler imaging. Using principal component analysis, we summarized 7 Doppler indexes - namely, E, A, e′ and a′ velocities, and their ratios (E/A, e′/a′, and E/e′) - into a single diastolic score. According to published definitions, 73 (9.5%) participants had impaired relaxation and 114 (14.9%) had elevated LV filling pressure. In the continuous analysis, a doubling of dp-ucMGP is associated with a 6.9% increase in the diastolic score (95% CI 2.7–10.6, P < 0.001). No association was seen between systolic function and dp_ucMGP. Multivariable-adjusted odds ratio for a doubling of dp-ucMGP was 0.70 (95% CI 0.50–0.98; P = 0.038) for having elevated LV filling pressure. No significant association was seen between impaired relaxation and dp-ucMGP.

Conclusion: Higher circulating levels of dp-ucMGP are associated with better LV diastolic function. Pending confirmation in other cohorts and further experimental studies are required to translate our epidemiological findings into underlying molecular mechanisms.

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<Previous Article In Issue
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Journal
Artery Research
Volume-Issue
12 - C
Pages
46 - 46
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.029How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Thibault Petit*
AU  - Zhen-Yu Zhang
AU  - Wen-Yi Yang
AU  - Fang-Fei Wei
AU  - Yu-Mei Gu
AU  - Juditha Knez
AU  - Nicholas Cauwenberghs
AU  - Yan-Ping Liu
AU  - Nadja Drummen
AU  - Lotte Jacobs
AU  - Lutgarde Thijs
AU  - Tatiana Kuznetsova
AU  - Stefan Janssens
AU  - Cees Vermeer
AU  - Jan A. Staessen
PY  - 2015
DA  - 2015/11/23
TI  - 5.4 MATRIX GLA PROTEIN IN RELATION TO LEFT VENTRICULAR DIASTOLIC FUNCTION
JO  - Artery Research
SP  - 46
EP  - 46
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.029
DO  - 10.1016/j.artres.2015.10.029
ID  - Petit*2015
ER  -