Managing Endocrine Disorders in Adults After Hematopoietic Stem Cell Transplantation

DOI

10.2991/chi.d.190917.001How to use a DOI?

Keywords

Stem cell transplant; Endocrine complications; Post-transplant diabetes; Transplant complications; Transplant survivorship

Abstract

Hematopoietic stem cell transplantation (HSCT) has become a potentially curative therapy for an increasing number of malignant and non-malignant conditions. As survival rates continue to improve, the focus of patient care has shifted from managing not only immediate but also long-term complications. Endocrine disorders are among the most prevalent late effects following HSCT. Detecting and treating such conditions offer new challenges, as well as opportunities to reduce preventable morbidity and mortality associated with HSCT. Our objective is to summarize recent literature and describe practical approaches to screening for and managing endocrine-related late effects. We focus on dyslipidemia, diabetes, thyroid disorders, osteoporosis, and hypogonadism. Mechanisms, monitoring, and management recommendations for each disorder are outlined. Growing data on these disorders in the post-transplant setting highlight the need for future study and evidence-based guidelines.

Copyright

© 2019 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Juliana Matthews
AU  - Dwight Eplin
AU  - Bipin Savani
AU  - Barbara Gisella Carranza Leon
AU  - Leslee Matheny
PY  - 2019
DA  - 2019/09/24
TI  - Managing Endocrine Disorders in Adults After Hematopoietic Stem Cell Transplantation
JO  - Clinical Hematology International
SP  - 180
EP  - 188
VL  - 1
IS  - 4
SN  - 2590-0048
UR  - https://doi.org/10.2991/chi.d.190917.001
DO  - 10.2991/chi.d.190917.001
ID  - Matthews2019
ER  -